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Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats

Jun Liu, Linbin Cai, Yuanyuan He, Jun Yang
  • Jun Liu
    Shanghai Jiaotong University School of Medicine, China
  • Linbin Cai
    Shanghai Jiaotong University School of Medicine, China
  • Yuanyuan He
    Shanghai Jiaotong University School of Medicine, China

Abstract

Kölliker’s organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5’-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To reveal the apoptosis of Kölliker’s organ in new-born rats, we studied the morphological changes and expression of apoptosis-related factors during early postnatal development. We found SCs in Kölliker’s organ decreased in number and changed in appearance along the cochlea apex-to-base gradient, and the expression of caspase-3, caspase-8, caspase-9 and bcl-2 in Kölliker’s organ of the cochlea fluctuated along the course of postnatal development, with an expression peak at postnatal day 3. This study demonstrates a time-dependent degeneration of Kölliker’s organ during postnatal cochlea development, which might be triggered by endogenous factors. 

Keywords

Kölliker’s organ; supporting cells; apoptosis; development.

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Submitted: 2016-07-29 10:21:12
Published: 2017-08-07 09:25:41
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Copyright (c) 2017 Jun Liu, Linbin Cai, Yuanyuan He, Jun Yang

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