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In vivo imaging techniques: a new era for histochemical analysis

A. Busato, P. Fumene Feruglio, P.P. Parnigotto, P. Marzola, A. Sbarbati
  • A. Busato
    University of Verona, Department of Computer Science, Italy
  • P. Fumene Feruglio
    University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Italy
  • P.P. Parnigotto
    Foundation for Biology and Regenerative Medicine, Tissue Engineering and Signaling (TES) ONLUS, Italy
  • P. Marzola
    University of Verona, Department of Computer Science, Italy
  • A. Sbarbati
    University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Italy | andrea.sbarbati@univr.it

Abstract

In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.

Keywords

Magnetic resonance imaging; magnetic resonance spectroscopy; functional magnetic resonance imaging; diffusion tensor imaging; tissue analysis; contrast agents.

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Submitted: 2016-09-14 17:54:46
Published: 2016-11-28 13:04:54
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Copyright (c) 2016 Alice Busato, Paolo Fumene Feruglio, Pier Paolo Parnigotto, Pasquina Marzola, Andrea Sbarbati

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