“HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES: G. Di Sante1, A. M. Stabile1, A. Pistilli1, M. Ruggirello1,2, F. Michetti3,4, F. Ria2, M. Rende1 | 1 Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; 2Department of Translational Medicine and Surgery, Section of General Pathology, University ‘Cattolica del Sacro Cuore’ of Rome, Roma, Italy; 3Department of Medicine, LUM University, Casamassima, Bari, Italy; 4Italy Genes, Rome, Italy ” (2025) European Journal of Histochemistry, 69(s2). doi:10.4081/ejh.2025.4314.