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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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ON THE WAY TO A NEW MODEL OF NEURODEGENERATION? FIRST EVIDENCE OF THE EXPRESSION OF GATA1 IN THE BRAIN: CORRELATIONS WITH AGING, MITOCHONDRIAL DAMAGE AND SYNUCLEINOPATHY C. Caturano1, F. E. Bellomi1, F. Arciprete1, V. Velardi1, L. La Barbera2, M. Falchi3, M. Bacioglu4, R. Mancinelli5, M. D’Amelio2, M. Spillantini4, M. Zingariello1, G. Vivacqua1,6 | 1Laboratory of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Rome, Italy; 2Laboratory of Molecular Neuroscience - Campus Biomedico University of Rome, Italy; 3National Centre for HIV/AIDS Research, Istituto Superior di Sanità, Rome, Italy; 4Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK; 5Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy; 6Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
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EXPERIMENTAL PARKINSONISM RECRUITS CHOLINERGIC MEDIAL SEPTAL NEURONS Lenzi P1, Lazzeri G1, Ferrucci M1, Scotto M1, Giambelluca MA1, Binda P1 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2IRCCS, Neuromed, Pozzili, Italy
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An improved method for preparation of mouse retinal cryosections
2340PDF: 1413Supplementary: 191HTML: 594 -
09 | MODULATION OF ETOSIS BY BIOACTIVE EXTRACTS DERIVED FROM MARINE RESOURCES AND AGRI-FOOD BY-PRODUCTS F. Bellistrì1, G. Abruscato1, M. Perlotti1, A. Lo Muzzo1, C. Gargano1, F. Longo1, M. Mauro1, R. Chiarelli1, V. Arizza1|3, C. Luparello1|3, G. Sarà2|3, M. Vazzana1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Earth and Marine Sciences, Palermo, Italy; 3National Biodiversity Future Center, Palermo, Italy
158PDF: 18 -
Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma
2026PDF: 740Supplementary: 149HTML: 31 -
WHOLE-BRAIN CATECHOLAMINERGIC CONNECTOMICS IN ALZHEIMER’S DISEASE Bellomi FE1, Loffredo G2, Petrocchi F1, Ullman NS1, Caturano C1, Cauzzi E2, Cognini F3, Mittoni F4, LaBarbera L2, Soda P5, D’Amelio M2 and Vivacqua G1 | 1Microscopic and Ultrastructural Anatomy Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 2Molecular Neuroscience Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 3Carl Zeiss S.p.A., Milan, Italy; 4Interconsulting services, RINA Services S.p.A., Rome, Italy; 5Department of Bio-engineering, Campus Bio-medico University of Rome, Rome, Italy
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P65 | (YS) INVESTIGATING THE EFFECTS OF THE SECRETOME FROM HUMAN AMNIOTIC MESENCHYMAL STROMAL CELLS ON INFLAMMASOME ACTIVATION M. Rossi1, M. Magatti2, P. Romele2, E. Vertua2, E. Giuzzi2, S. Farigu2, L. Marelli2, B. Rapuzzi2, S. De Munari2, A. Silini2, O. Parolini3 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, and Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 2Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 3Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy & Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy
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Histological and Histochemical Methods - Theory and practice
4193PDF: 2192HTML: 191 -
57 | PUNICA GRANATUM-DERIVED EXTRACELLULAR VESICLES EFFECTS ON AN IN VITRO GASTROINTESTINAL BARRIER MODEL OF INTESTINAL INFLAMMATION Mariano Stefania1, Carata Elisabetta2, Moris Destino2, Bernardetta Anna Tenuzzo2, Panzarini Elisa2 | 1Department of Mathematics and Physics “E. De Giorgi”, University of Salento, Lecce, Italy; 2Department of Biological Sciences and Technologies, University of Salento, Lecce, Italy
47PDF: 38 -
Sox9 expression in canine epithelial skin tumors
3203PDF: 898HTML: 408 -
P06 | MICROGRAVITY-INDUCED CHANGES IN CYTOSKELETON STRUCTURE OF TCAM-2 CELLS M. Berardini1, L. Gesualdi1, A. Di Pauli1, M. Signore2, S. Broccolucci1, F. Ferranti3, M. Bizzarri4, M. Tafani4, G. Ricci5, A. Catizone1 | 1Dept of Anatomy, Histology, Forensic-Medicine and Orthopedics,“Sapienza” University of Rome, Rome, Italy; 2RPPA Unit, Proteomics Area, Core Facilities, Istituto Superiore di Sanità, Rome, Italy; 3Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; 4Dept of Experimental Medicine “Sapienza” University of Rome, Rome, Italy; 5Dept of Experimental Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy
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Syndecan expressions in the human amnion and chorionic plate
1877PDF: 667HTML: 671 -
INVESTIGATION OF STRUCTURAL PRESERVATION OF PERIPHERAL NERVE EXTRACELLULAR MATRIX FOLLOWING EX VIVO LIMB PERFUSION Metafune M1,2, Haastert-Talini K3, Muratori L1,2 and Raimondo S1,2 | 1Department of Clinical and Biological Sciences, Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Turin, Italy; 2Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Lower-Saxony, Germany
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Optimization of the autophagy measurement in a human cell line and primary cells by flow cytometry
2143PDF: 1236Supplementary: 197HTML: 32 -
Expression pattern of thymosin beta 4 in the adult human liver
1608PDF: 711HTML: 1367 -
28 | 3D MORPHO-FUNCTIONAL RECONSTRUCTION OF THE PREPUBERTAL MOUSE OVARY COMBINING NANO-COMPUTED TOMOGRAPHY AND CONFOCAL IMAGING A. Fantinato1|4, G. Fiorentino1|4, A. Parrilli2, G. Brazzale1, V. Merico1, P. Rebuzzini1, D. Cimadomo1|3, S. Garagna1, M. Zuccotti1 | 1Dept. of Biology and Biotechnology, University of Pavia, Italy; 2Empa-Swiss Federal Laboratories for Materials Science and Technology, Switzerland; 3IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Italy; 4Equal contribution
52PDF: 16 -
THE USE OF BIOMIMETIC 2D AND 3D UROTHELIAL IN VITRO MODELS WITH MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF NORMAL AND CANCEROUS BLADDER TISSUE AS AN ALTERNATIVE METHOD IN PRECLINICAL STUDIES M.E. Kreft1, L. Tratnjek1, A. Janev1, N. Resnik1, U. Cerkvenik1, U. D. Jerman1, G. Markovič1, T.Ž. Ramuta1, T. Višnjar1, Ž. Sardoč1, A.Punčuh1, S. Kralj2, M. Čemažar3, P. Veranič1 |1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; 2Department for Materials Synthesis, Jožef Stefan Institute, Ljubljana, Slovenia; 3Institute of Oncology Ljubljana, Ljubljana, Slovenia
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SENSORY NEURON TOXICITY TRIGGERED BY ANTICANCER DRUGS IS COUNTERACTED BY EXTRACELLULAR VESICLES DERIVED FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS D’Aprile C1, Naghshbandieh A1,3, Fabbro V1, Turano E2, Scambi I2, Virla F2, Caprioli M2, Mariotti R2, Scuteri A1 and Meregalli C1 | 1Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Italy; 2Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 3PhD Program in Neuroscience, University of Milano- Bicocca, Italy
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P67 | EMERGING ROLE OF NUCLEAR PHOSPHOLIPASE C BETA 1 AS POTENTIAL BIOMARKER IN LUNG CANCER S. Salucci1, I. Versari1, S. Burattini2, D. Montecchio3, I. Faenza1 | 1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 2Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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62 | APPLICATION OF AN AI-BASED WORKFLOW FOR THE ASSESSMENT OF TESTICULAR DAMAGE IN DOGS Lorenzo Riccio1|2, Maria De Falco2, Nicola Ambrosio3, Angelo Spada3, Francesca Del Porto2, Cristina Marchetti2, Orlando Paciello1, Luigi Rosati2 | 1Dept. of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy; 2Dept. of Biology, University of Naples Federico II, Italy; 3ASL Napoli 2 Nord, Italy
48PDF: 22 -
Erythrocytes of the Rhesus and Cynomolgus Monkeys
1044PDF: 498HTML: 10 -
TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti1, M. C. Gagliani2, G. Bellese2, M. Crippa3, A. Abbona4, M. Paccagnella4, P. Arnaldi5, M. C. Merlano6, O. Garrone7, A.M. Porcelli8, M. Matteoli1, P. Falletta9, P. Castagnola10, K. Cortese2 | 1IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; 2DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; 3Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; 4Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; 5IRCCS Ospedale Policlinico San Martino, Genova, Italy; 6Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; 7Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 8FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; 9Vita-Salute San Raffaele University, Milan, Italy; 10IRCCS Ospedale Policlinico San Martino, Genova, Italy
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ECRG4 expression in normal rat tissues: expression study and literature review
3089PDF: 1187Supplementary: 393HTML: 1018 -
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EX VIVO MAPPING OF NIGRO-THALAMIC DOPAMINERGIC TERMINALS REVEALS REGIONAL SPECIALIZATION AND SYNAPTIC MARKERS IN THE HUMAN THALAMUS Cirillo G1, Montella M2, La Mantia E2, Tedesco I2, De Luca C1, Virtuoso A1, De Angelis F1, Riccio L1, Esposito F3, Cirillo M3, Franco R2 and Papa M1 | 1Division of Human Anatomy, Neuronal Networks Morphology & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 3Department of Advanced Medical and Surgical Sciences, Advanced MRI Research Center, University of Campania Luigi Vanvitelli, Naples, Italy
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P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo1, V. Gallicchio1, A. Lallo1, F. Carrella1, D. Barbarisi2, A. Falzarano1, M. De Falco3, F. Flora2, A. Peluso2, S. Piccolo2, L. Flora2 | 1Department of Science and Technologies, University of Sannio, Italy; 2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; 3Department of Biology, University of Naples, Italy
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P14 | IMMUNE HANDLING OF PET NANOPLASTICS IN POMACEA CANALICULATA: ACCUMULATION BY CIRCULATING AND TISSUE-RESIDENT HEMOCYTES FOLLOWING ACUTE EXPOSURE A. Ferri1, S. Sacchi1, C. Losi2, M. Amico1, D. Malagoli1 | 1Dept. of Life Science, University of Modena and Reggio Emilia, Italy; 2Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy; 3NBFC, National Biodiversity Future Center, Italy
36PDF: 18 -
David Glick Award Lecture | SUPER RESOLUTION MICROSCOPY: NEW APPROACHES TO DISCOVER THE TOPOGRAPHICAL SECRETS OF GENE REGULATION C. Cremer1,2,3 | 1Institute of Molecular Biology (IMB), Mainz, Germany; 2Max Planck Institute for Polymer Research, and for Chemistry, Mainz, Germany; 3Interdisciplinary Center for Scientific Computing (IWR), and Kirchhoff Institute for Physics, University Heidelberg, Heidelberg, Germany
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Expression of S100β during mouse cochlear development
1475PDF: 401Supplementary: 76HTML: 9
