Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren’s histologic subtypes of gastric carcinomas


Laurèn’s system subdivides gastric cancers into an intestinal type and a diffuse type. This histological classification mirrors histogenetic hypotheses according to which the intestinal- type cancer derives from intestinal metaplasia and dysplasia, while the diffuse-type originates directly from gastric mucosa, with or without a preceding non-metaplastic dysplasia. Studies concerning mucins expression in gastric neoplastic and preneoplastic lesions have provided contradictory data concerning such histogenetic relationships. The aim of the present study was to verify whether a correlation between mucins phenotype and Lauren’s classification subsists. 40 gastric adenocarcinomas, subdivided, according to Laurèn’s classification, into 27 intestinal-type, 10 diffusetype and 3 unclassified cases, were examined for MUC1 and MUC2 immunohistochemical expression. Intestinal-type carcinomas displayed a MUC1-positive staining in 23/27 cases and a MUC2-positive immunoreaction in 10/27 cases. Diffuse-type carcinomas expressed MUC1 in 3/10 and MUC2 in 8/10 cases, respectively. According to the mucins expression pattern, three phenotypes were identified: the gastric phenotype (MUC1+/MUC2–); the gastro-intestinal phenotype (MUC1+/MUC2+) and the intestinal phenotype (MUC1–/MUC2+). The gastric phenotype was significantly higherin intestinal-type adenocarcinomas, whereas cases showing an intestinal phenotype were significantly more frequent in diffuse-type adenocarcinomas. These findings provide evidence for a lack of correlation between Lauren’s classification and MUC1 and MUC2 phenotypes. In particular, the term intestinal-type tumour as referred to gland-forming gastric cancer does not seem to reflect an immunohistochemical phenotype.


Download data is not yet available.
Original Papers
Abstract views: 183

PDF: 108
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Barresi, V., Vitarelli, E., Grosso, M., Tuccari, G., & Barresi, G. (2009). Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren’s histologic subtypes of gastric carcinomas. European Journal of Histochemistry, 50(4), 301-310.

Most read articles by the same author(s)