Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis


Although some experimental evidence has implicated the TRAIL/TRAIL-receptor system in the regulation of osteoclastogenesis, the only available studies performed so far have been performed on isolated pre-osteoclasts, induced to differentiate by the addition of recombinant RANKL and M-CSF. Using a more physiological co-culture system in the absence of exogenous cytokines, we have here demonstrated that recombinant TRAIL inhibits osteoclast formation, but only at relatively high concentrations (500 ng/mL).


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How to Cite
Nicolin, V., Narducci, P., & Celeghini, C. (2009). Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis. European Journal of Histochemistry, 52(1), 75-78. https://doi.org/10.4081/1189

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