Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

  • G. Tomasello Università di Palermo, Italy.
  • C. Sciumé Università di Palermo, Italy.
  • F. Rappa Università di Palermo, Italy.
  • V. Rodolico Università di Palermo, Italy.
  • M. Zerilli Università di Palermo, Italy.
  • A. Martorana Università di Palermo, Italy.
  • G. Cicero Università di Palermo, Italy.
  • R. De Luca Università di Palermo, Italy.
  • P. Damiani Università di Palermo, Italy.
  • F.M. Accardo Università di Palermo, Italy.
  • M. Romeo Istituto di Medicina Biologica, Milano, Italy.
  • F. Farina Università di Palermo, Italy.
  • G. Bonaventura Università di Palermo, Italy.
  • G. Modica Università di Palermo, Italy.
  • G. Zummo Università di Palermo, Italy.
  • E. Conway de Macario University of Maryland at Baltimore - IMET, Baltimore, MD, United States.
  • A.J.L. Macario University of Maryland at Baltimore - IMET, Baltimore, MD, United States.
  • F. Cappello | francapp@hotmail.com Università di Palermo, Italy.

Abstract

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones: Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).

Downloads

Download data is not yet available.

Author Biographies

G. Tomasello, Università di Palermo
Dipartimento di Discipline Chirurgiche ed Oncologiche
C. Sciumé, Università di Palermo
Dipartimento di Discipline Chirurgiche ed Oncologiche
F. Rappa, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
V. Rodolico, Università di Palermo
Dipartimento di Patologia Umana
M. Zerilli, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
A. Martorana, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
G. Cicero, Università di Palermo
Dipartimento di Oncologia
R. De Luca, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
P. Damiani, Università di Palermo
Dipartimento di Medicina Interna e delle Malattie Emergenti
F.M. Accardo, Università di Palermo
Dipartimento di Contabilità Nazionale ed Analisi dei Processi Sociali
F. Farina, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
G. Bonaventura, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
G. Modica, Università di Palermo
Dipartimento di Discipline Chirurgiche ed Oncologiche
G. Zummo, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
E. Conway de Macario, University of Maryland at Baltimore - IMET, Baltimore, MD
Department of Microbiology and Immunology,  School of Medicine
A.J.L. Macario, University of Maryland at Baltimore - IMET, Baltimore, MD
Department of Microbiology and Immunology,  School of Medicine
F. Cappello, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
Published
2011-10-24
Section
Brief Reports
Supporting Agencies
University of Palermo, Istituto Euro-Mediterraneo di Scienza e Tecnologia
Keywords:
ulcerative colitis, heat shock proteins, Hsp, molecular chaperones, inflammation, comorbidity
Statistics
Abstract views: 470

PDF: 208
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Tomasello, G., SciuméC., Rappa, F., Rodolico, V., Zerilli, M., Martorana, A., Cicero, G., De Luca, R., Damiani, P., Accardo, F., Romeo, M., Farina, F., Bonaventura, G., Modica, G., Zummo, G., Conway de Macario, E., Macario, A., & Cappello, F. (2011). Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. European Journal of Histochemistry, 55(4), e38. https://doi.org/10.4081/ejh.2011.e38