Development of synovial membrane in the temporomandibular joint of the human fetus

Main Article Content

L.O. Carvalho de Moraes *
R.C. Tedesco
L.A. Arraez-Aybar
O. Klein
J.R. Mérida-Velasco
L.G. Alonso
(*) Corresponding Author:
L.O. Carvalho de Moraes | luisotavio27@yahoo.com.br

Abstract

The development of the synovial membrane was analyzed in serial sections of 21 temporomandibular joints of human fetuses at 9 to 13 weeks of gestation. Sections of two fetuses at 12 weeks of development were used to perform immunohistochemical expression of the markers CD68 and Hsp27 on the synovial lining. Macrophage-like type A and fibroblast-like type B cells, which express CD68 and Hsp27, respectively, were observed at the twelfth week of development. Our results suggest that the development of the synovial membrane is related to the vascularization of the joint and the formation of the articular cavities.

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Author Biographies

L.O. Carvalho de Moraes, Federal University of São Paulo

Department of Morphology and Genetics

R.C. Tedesco, Federal University of São Paulo

Department of Morphology and Genetics

L.A. Arraez-Aybar, University Complutense of Madrid

Department of Anatomy and Embryology

O. Klein, University of California, San Francisco

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology

J.R. Mérida-Velasco, University Complutense of Madrid

Department of Anatomy and Embryology

L.G. Alonso, Federal University of São Paulo

Department of Morphology and Genetics