Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis

Submitted: 25 September 2015
Accepted: 12 November 2015
Published: 1 December 2015
Abstract Views: 1603
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Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.

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Supporting Agencies

University of Pavia
M. Malatesta, Università di Verona
Dipartimento di Scienze Neurologiche, Biomediche e del Movimento, sezione di Anatomia e Istologia
P. Veneroni, Università di Pavia
Dipartimento di Biologia e Biotecnologie “L. Spallanzaniâ€
M.G. Bottone, Università di Pavia
Dipartimento di Biologia e Biotecnologie “L. Spallanzaniâ€

How to Cite

Aredia, F., Malatesta, M., Veneroni, P., & Bottone, M. (2015). Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis. European Journal of Histochemistry, 59(4). https://doi.org/10.4081/ejh.2015.2571

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