In vivo imaging techniques: a new era for histochemical analysis

Submitted: 14 September 2016
Accepted: 17 November 2016
Published: 28 November 2016
Abstract Views: 1349
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In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.

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Busato, A., Fumene Feruglio, P., Parnigotto, P., Marzola, P., & Sbarbati, A. (2016). In vivo imaging techniques: a new era for histochemical analysis. European Journal of Histochemistry, 60(4). https://doi.org/10.4081/ejh.2016.2725

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