https://doi.org/10.4081/ejh.2017.2783
Characterization of the role of RILP in cell migration
Accepted: 18 May 2017
Supplementary: 205
Movie 1: 264
Movie 2: 309
HTML: 94
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Rab-interacting lysosomal protein (RILP) is a regulator of late stages of endocytosis. Recent work proved that depletion of RILP promotes migration of breast cancer cells in wound healing assay, whereas its overexpression influences re-arrangements of actin cytoskeleton. Here, we further characterized the role of RILP in cell migration by analyzing several aspects of this process. We showed that RILP is fundamental also for migration of lung cancer cells regulating cell velocity. RILP silencing did not affect Golgi apparatus nor microtubules reorientation during migration. However, both RILP over-expression and expression of its mutated form, RILP-C33, impair cell adhesion and spreading. In conclusion, our results demonstrate that RILP has important regulatory roles in cell motility affecting migration velocity but also in cell adhesion and cell spreading.
Supporting Agencies
AIRC (Grant IG19068 to CB), Telethon Italy (Grant GGP16037 to CB), Norwegian Cancer Society (Grants 5760850 to CP and 4604944 to OB), Research Council of Norway (grants 239903 to CP, 230779 to OB, and Centre of Excellence funding project 179573)How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- L. M. Carrillo, E. Arciniegas, H. R. Rojas, R. E. Ramirez, Immunolocalization of endocan during the endothelial-mesenchymal transition process , European Journal of Histochemistry: Vol. 55 No. 2 (2011)
- V. Matozzo, M. G. Marin, First cytochemical study of haemocytes from the crab Carcinus aestuarii (Crustacea, Decapoda) , European Journal of Histochemistry: Vol. 54 No. 1 (2010)
- Xiong Bing Li, Jia Li Li, Chao Wang, Yong Zhang, Jing Li, Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
- ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu, Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress , European Journal of Histochemistry: Vol. 68 No. 4 (2024)
- H. Sawai, N. Domae, Transfer of Fas (CD95) protein from the cell surface to the surface of polystyrene beads coated with anti-Fas antibody clone CH-11 , European Journal of Histochemistry: Vol. 54 No. 1 (2010)
- Jun Lin, Liping Jiang, Kun Guo, Ning Feng, Decreased VEGFA alleviates the symptoms of LPS-induced sepsis in a mouse model by inhibiting glycolysis and thereby regulating the polarization of macrophages , European Journal of Histochemistry: Vol. 67 No. 1 (2023)
- Yangying Peng, Shaojie Ding, Ping Xu, Xueyan Zhang, Jianzhang Wang, Tiantian Li, Liyun Liao, Xinmei Zhang, CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
- Yuhan Wang, Gang Wang, Xiaojun Liu, Dong Yun, Qing Cui, Xiaoting Wu, Wenfeng Lu, Xiwen Yang, Ming Zhang, Inhibition of APLN suppresses cell proliferation and migration and promotes cell apoptosis in esophageal cancer cells in vitro, through activating PI3K/mTOR signaling pathway , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- Viktória Dénes, Kármen Kovacs, Ákos Lukáts, Adrienn Mester, Gergely Berta, Arnold Szabó, Robert Gabriel, Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina , European Journal of Histochemistry: Vol. 66 No. 2 (2022)
- Fenqiang Qi, Yuxin Deng, Wei Huang, Yanli Cai, Kelin Hong, Shui Xiang, Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy , European Journal of Histochemistry: Vol. 68 No. 4 (2024)
<< < 2 3 4 5 6 7 8 9 10 11 > >>
You may also start an advanced similarity search for this article.
Publication Facts
Reviewer profiles N/A
Author statements
- Editor & editorial board
- profiles
- Academic society
- N/A
- Publisher
- PAGEPress Publications, Pavia, Italy
To learn about these publication facts, click 
PF is maintained by the Public Knowledge Project
