https://doi.org/10.4081/ejh.2017.2783
Characterization of the role of RILP in cell migration
Accepted: 18 May 2017
Supplementary: 206
Movie 1: 270
Movie 2: 317
HTML: 94
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Rab-interacting lysosomal protein (RILP) is a regulator of late stages of endocytosis. Recent work proved that depletion of RILP promotes migration of breast cancer cells in wound healing assay, whereas its overexpression influences re-arrangements of actin cytoskeleton. Here, we further characterized the role of RILP in cell migration by analyzing several aspects of this process. We showed that RILP is fundamental also for migration of lung cancer cells regulating cell velocity. RILP silencing did not affect Golgi apparatus nor microtubules reorientation during migration. However, both RILP over-expression and expression of its mutated form, RILP-C33, impair cell adhesion and spreading. In conclusion, our results demonstrate that RILP has important regulatory roles in cell motility affecting migration velocity but also in cell adhesion and cell spreading.
Downloads
Publication Facts
Reviewer profiles N/A
Author statements
- Editor & editorial board
- profiles
- Academic society
- N/A
- Publisher
- PAGEPress Publications, Pavia, Italy
To learn about these publication facts, click 
PF is maintained by the Public Knowledge Project
Citations
Supporting Agencies
AIRC (Grant IG19068 to CB), Telethon Italy (Grant GGP16037 to CB), Norwegian Cancer Society (Grants 5760850 to CP and 4604944 to OB), Research Council of Norway (grants 239903 to CP, 230779 to OB, and Centre of Excellence funding project 179573)How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Viktória Dénes, Kármen Kovacs, Ákos Lukáts, Adrienn Mester, Gergely Berta, Arnold Szabó, Robert Gabriel, Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina , European Journal of Histochemistry: Vol. 66 No. 2 (2022)
- Fenqiang Qi, Yuxin Deng, Wei Huang, Yanli Cai, Kelin Hong, Shui Xiang, Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy , European Journal of Histochemistry: Vol. 68 No. 4 (2024)
- Nan Li, Xue Fan, Lihong Liu, Yanbing Liu, Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure , European Journal of Histochemistry: Vol. 67 No. 3 (2023)
- Zhi-bao Liu, Jing-hua Zhang, Jing-hua Gao, Jian Shi, Effects of the lncRNA ENST00000623984 on colon cancer and the biological characteristics of colon cancer cells , European Journal of Histochemistry: Vol. 65 No. 3 (2021)
- Yunlong Zhang, Xin He, Jianyu Zou, Jie Yang, Ao Ma, Minghui Tan, Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability , European Journal of Histochemistry: Vol. 67 No. 1 (2023)
- Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi, Immunohistochemical expression and clinicopathological assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in highly aggressive soft tissue sarcomas , European Journal of Histochemistry: Vol. 66 No. 2 (2022)
- Mariko Kawai, Yu-Ki Ohmori, Mai Nishino, Masayo Yoshida, Kaori Tabata, Do-Saku Hirota, Ayako Ryu-Mon, Hiromitsu Yamamoto, Junya Sonobe, Yo-Hei Kataoka, Noriko Shiotsu, Mika Ikegame, Hiroki Maruyama, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura, Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation , European Journal of Histochemistry: Vol. 61 No. 2 (2017)
- Yin Pan, Di Qiu, Shu Chen, Xiaoxue Han, Ruiman Li, High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma , European Journal of Histochemistry: Vol. 67 No. 2 (2023)
- Y. Dong, C. Yang, Z. Wang, Z. Qin, J. Cao, Y. Chen, The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice , European Journal of Histochemistry: Vol. 60 No. 4 (2016)
- J. Zhang, J. Luo, J. Ni, L. Tang, H.P. Zhang, L. Zhang, J.F. Xu, D. Zheng, MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells , European Journal of Histochemistry: Vol. 58 No. 1 (2014)
<< < 3 4 5 6 7 8 9 10 11 12 > >>
You may also start an advanced similarity search for this article.
