Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances

  • Zhi Chen Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
  • Na Cui Department of ICU, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
  • Ji-sen Zhao Department of Anesthesiology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Jian-fei Wu Department of Anesthesiology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Fang Ma Department of Anesthesiology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Cong Li Department of Anesthesiology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Xian-yi Liu | nzix32@163.com Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.

Abstract

As the leading malignancy among women, breast cancer is a serious threat to the life and health of women. In this context, it is of particular importance that a proper therapeutic target be identified for breast cancer treatment. We collected the pathological tissues of 80 patients, with the view to discovering appropriate molecular targets for the treatment of breast cancer, this paper analyzes the expressions of ZNF436, β-catenin, EGFR and CMTM5 in breast cancer tissues, as well as their correlations with breast cancer in combination with the clinicopathologic characteristics of studied patients. Immunohistochemistry (IHC) was utilized to detect the expression levels of ZNF436, β-catenin, EGFR and CMTM5 in cancerous and paracancerous tissues of breast cancer patients. The expression levels of ZNF436, β-Catenin and EGFR in breast cancer tissues were significantly greater than those in paracancerous tissues in this study (p<0.05), while CMTM5 was highly expressed in paracancerous tissues (p<0.05). Additionally, the correlation of the expressions of such indicators with the staging, differentiation and lymphatic metastasis of breast cancer, were also found to be statistically significant at the level p<0.05. The different expression levels of ZNF436, β-catenin, EGFR and CMTM5 in breast cancer and paracancerous tissues open up the possibility of utilizing them as molecular markers for breast cancer. These findings provide a theoretical basis for targeted molecular therapies for breast cancer, and hence carry a significant practical significance.

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Published
2021-01-20
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Keywords:
Breast cancer, ZNF436, β-catenin, EGFR, CMTM5, immunohistochemistry
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How to Cite
Chen, Z., Cui, N., Zhao, J.- sen, Wu, J.- fei, Ma, F., Li, C., & Liu, X.- yi. (2021). Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances. European Journal of Histochemistry, 65(1). https://doi.org/10.4081/ejh.2021.3173