Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings

Submitted: 28 August 2020
Accepted: 27 October 2020
Published: 3 December 2020
Abstract Views: 869
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Authors

A high incidence of heterotopic ossification (HO) has been reported in patients with diffuse idiopathic skeletal hyperostosis (DISH), a metabolic disease characterized by calcifications of entheses at spine and peripheral sites. We performed histological and immunohistochemical analyses in five different HO sites in a patient with DISH to study a possible mutual interaction of bone morphogenetic protein 2 (BMP-2), transforming growth factor beta (TGF-β), and decorin, crucial for bone mass increasing, matrix calcification, and endochondral bone formation. We speculated that the surgical trauma triggered HO, inducing TGF-β release at the lesion site. TGF-β recruits osteoblast precursor cells and determines the overexpression of BMP-2 in the surrounding skeletal muscle, inducing a further osteogenic differentiation, contributing to HO onset.

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Caterina Licini, Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona

Department of Applied Sciences and Technology (DISAT), Politecnico di Torino, Turin

How to Cite

Licini, C., Farinelli, L., Cerqueni, G., Hosein, A., Marchi, S., Gigante, A., & Mattioli-Belmonte, M. (2020). Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings. European Journal of Histochemistry, 64(4). https://doi.org/10.4081/ejh.2020.3176

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