https://doi.org/10.4081/ejh.2024.4122
Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction
Submitted: 6 August 2024
Accepted: 9 October 2024
Published: 28 October 2024
Accepted: 9 October 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Heart failure with preserved ejection fraction (HFpEF), a complex disease that is increasingly prevalent due to population aging, pose significant challenges in its treatment. The present study utilized the HFpEF rat model and H9C2 cells as research subjects to thoroughly investigate the potential mechanisms of alarin in protecting cardiac function in HFpEF. The study shows that under HFpEF conditions, oxidative stress significantly increases, leading to myocardial structural damage and dysfunction of calcium ion channels, which ultimately impairs diastolic function. Alarin, through its interaction with NADPH oxidase 1 (NOX1), effectively alleviates oxidative stress and modulates the activities of type 2 ryanodine receptor (RyR2) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2), thereby facilitating the restoration of Ca2+ homeostasis and significantly improving cardiac function in the HFpEF model. This research not only uncovers the cardioprotective effects of alarin and its underlying molecular mechanisms but also provides new insights and potential therapeutic targets for HFpEF treatment strategies, suggesting a promising future for alarin and related therapies in the management of this debilitating condition.
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Ethics Approval
the experiments on rats were approved by the Experimental Animal Care and Use Committee of Xuzhou Medical UniversitySupporting Agencies
Suqian Sci&Tech Program, Suqian Traditional Chinese Medicine Technology Program, Xuzhou Medical University Affiliated Hospital Sci&Tech ProgramHow to Cite
Li, J., Xu, D., Shi, C., Cheng, C., Xu, Z., Gao, X., & Cheng, Y. (2024). Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction. European Journal of Histochemistry, 68(4). https://doi.org/10.4081/ejh.2024.4122
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