Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals

Abstract

Functional interrelationships between the intranuclear organization of nucleic acids and regulatory proteins are obligatory for fidelity of transcriptional activation and repression. In this article, using the Runx/AML/Cbfa transcription factors as a paradigm for linkage between nuclear structure and gene expression we present an overview of growing insight into the dynamic organization and assembly of regulatory machinery for gene expression at microenvironments within the nucleus. We address contributions of nuclear microenvironments to the convergence and integration of regulatory signals that mediate transcription by supporting the combinatorial assembly of regulatory complexes.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2009-06-29
Info
Issue
Section
Original Papers
Statistics
  • Abstract views: 190

  • PDF: 283
How to Cite
Stein, G., Stein, J., Lian, J., & van Wijnen, A. (2009). Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals. European Journal of Histochemistry, 48(1), 65-76. https://doi.org/10.4081/860