Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma

  • M Alberghini | support@pagepress.org
  • P Bacchini
  • G Pignatti
  • MC Maltarello
  • L Zanella
  • NM Maraldi
  • F Bertoni

Abstract

Elastofibroma dorsi is a pseudotumoral fibroproliferative lesion characterized by polymorphic fiber-like deposits of elastinophilic material. Several theories have been reported explaining the pathogenesis of elastofibroma. Recent cytogenetic studies have demonstrated chromosomal instability in elastofibromas, not normally observed in non-neoplastic tissues. These chromosomal defects are commonly observed in aggressive fibromatosis too. Such clinical observations suggest a multistage pathogenetic mechanism for the onset of elastofibroma. This study, using histochemical, immunohistochemical staining techniques, and ultrastructural examination, describes the detection of an otherwise typical elastofibroma contextual to a high grade sarcoma. Hence, the coexistence of elastofibroma and high-grade sarcoma may suggest a causal link between the two pathological entities. The results obtained suggest that the coexistence of the two pathological entities is conceivably coincidental.

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Published
2009-06-29
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Original Papers
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How to Cite
Alberghini, M., Bacchini, P., Pignatti, G., Maltarello, M., Zanella, L., Maraldi, N., & Bertoni, F. (2009). Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma. European Journal of Histochemistry, 48(2), 173-178. https://doi.org/10.4081/884

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