Advanced microscopic and histochemical techniques: diagnostic tools in the molecular era of myology

Abstract

Over the past two centuries, myology (i.e. the basic and clinical science of muscle and muscle disease) has passed through 3 stages of development: the classical period, the modern stage and the molecular era. The classical period spans the last part of nineteenth century and the earlier part of the twentieth century. During this time, several major muscle disease were clinically and pathologically characterized, including Duchenne muscular dystrophy (DMD), myotonic dystrophy (DM) and facioscapulohumeral dystrophy (FSHD). The modern stage in the second half of the twentieth century is characterized by the adaptation of histo and cytochemical techniques to the study of muscle biopsies. These tools improved the diagnostic accuracy and made possible the identification of new changes and structures (Engel and Cunningham, 1963; Scarlato, 1975).

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2009-06-29
Info
Issue
Section
Views and Comments
Statistics
  • Abstract views: 411

  • PDF: 483
How to Cite
Meola, G. (2009). Advanced microscopic and histochemical techniques: diagnostic tools in the molecular era of myology. European Journal of Histochemistry, 49(1), 93-96. https://doi.org/10.4081/932