Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body

  • A. Porzionato | rdecaro@unipd.it
  • V. Macchi
  • A. Amagliani
  • I. Castagliuolo
  • A. Parenti
  • R. De Caro

Abstract

In the present study we investigated, through immunohistochemistry, the presence and location of neurotensin receptor 1 (NTR1) in the peripheral ganglia and carotid body of 16 humans and 5 rats. In both humans and rats, NTR1 immunostained ganglion cells were found in superior cervical ganglia (57.4±11.6% and 72.4±11.4%, respectively, p<0.05), enteric ganglia (51.9±10.4% and 64.6±6.1%, p<0.05), sensory ganglia (69.2±10.7% and 73.0±13.1%, p>0.05) and parasympathetic ganglia (52.1±14.1% and 59.4±14.0%, p>0.05), supporting a modulatory role for NT in these ganglia. Positivity was also detected in 45.6±9.2% and 50.8±6.8% of human and rat type I glomic cells, respectively, whereas type II cells were negative. Our findings suggest that NT produced by type I cells acts in an autocrine or paracrine way on the same cell type, playing a modulatory role on chemoception.

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Published
2009-09-23
Section
Original Papers
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How to Cite
Porzionato, A., Macchi, V., Amagliani, A., Castagliuolo, I., Parenti, A., & De Caro, R. (2009). Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body. European Journal of Histochemistry, 53(3), e16. https://doi.org/10.4081/ejh.2009.e16

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