Histopathological and immunohistochemical study of the hepatic lesions experimentally induced by Entamoeba dispar

Submitted: 1 May 2010
Accepted: 14 July 2010
Published: 26 August 2010
Abstract Views: 911
PDF: 523
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The sequence of hepatic necrotic-inflammatory events produced by Entamoeba dispar are originally described in this work. For the first time were described in details the experimental lesions produced by E. dispar, as well as the distribution of the trophozoites detected by the immunohistochemistry. Animals experimentally infected with E. dispar presented necrosis, thrombosis and chronic granulomatous inflammation. Immunoreactive products derived from trofozoites were observed close or associated with trophozoites, epithelioid cells, leucocytes and hepatocytes. Few are the articles on the literature about virulence of E. dispar, which is approximately 9 times more frequent than to E. histolytica. Variation in the virulence is, therefore expected and signalizing the need of the continuity of studies with E. dispar strains from different places in the world. Taking into account that E. dispar is a closely related species to E. histolytica, these studies could determine new elements involved with E. histolytica pathogenesis, helping us to understand better the disease.

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Supporting Agencies

FAPEMIG, CNPq
C. A. X. Costa, UFMG

Departamento de Patologia Geral

Programa de Pós-Graduação em Patologia da UFMG

K. N. O. de Brito, UFMG

Departamento de Patologia Geral

Programa de Pós-Graduação em Patologia da UFMG

M. A. Gomes, UFMG

Departamento de Parasitologia

M. V. Caliari, UFMG

Departamento de Patologia Geral

How to Cite

Costa, C. A. X., de Brito, K. N. O., Gomes, M. A., & Caliari, M. V. (2010). Histopathological and immunohistochemical study of the hepatic lesions experimentally induced by Entamoeba dispar. European Journal of Histochemistry, 54(3), e39. https://doi.org/10.4081/ejh.2010.e39

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