Significance and relationship between DJ-1 gene and survivin gene expression in laryngeal carcinoma

Submitted: 16 October 2010
Accepted: 22 February 2011
Published: 21 March 2011
Abstract Views: 994
PDF: 373
HTML: 1590
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

This study aimed at exploring the correlation between DJ-1 gene and survivin gene in laryngeal squamous cell carcinoma by analyzing their gene expression levels and their relationship with clinicopathologic parameters. The expression of DJ-1 gene and survivin gene in 82 laryngeal carcinoma tissues from patients and 82 negative surgical margin tissue samples were detected by immunohistochemistry, respectively. The correlation of their expression levels and patients’ clinical parameters were then analyzed by Pearson correlation analysis. The positive detection rates of DJ-1 and survivin in laryngeal carcinoma tissues were 71.95% and 60.98%, which were higher than those of the normal control that were 29.27% and 0.00%, respectively (P<0.01). The positive detection rates of DJ-1 and survivin were found associated with tumor stages (P<0.05), but not with lymph node metastasis. The DJ-1 gene expression level was related to cell differentiation (P<0.05). Finally, a positive correlation between DJ-1 and survivin gene expression in laryngeal carcinoma was found. The overall survival rate of patients was 51.2%, and disease-free survival (DFS) was 39.0%. DFS in DJ-1 negative-expression group was 87.0%, and 20.3% in DJ-1 positive-expression group. The negative expression of DJ-1 was associated with a shorter mean patient DFS time (44.643±1.417 months), whereas positive expression of DJ-1 was associated with a longer mean DSF time (25.943±1.297 months). DJ-1 and survivin play a vital role in the occurrence and development of laryngeal carcinoma. DJ-1 may promote the carcinogenesis of laryngeal cells by up-regulating the survivin gene expression.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Supporting Agencies

This work was supported by grants from the Ningbo Social Developmental Key Research Project (No. 2008C50019) and the K. C. Wong Magna Fund in Ningbo University.
Z. Shen, Lihuili Hospital of Ningbo University
Department of Otorhinolaryngology-Head and Neck Surgery
D. Ye, Lihuili Hospital of Ningbo University
Department of Otorhinolaryngology-Head and Neck Surgery
H. Ding, Lihuili Hospital of Ningbo University
Department of Pathology

How to Cite

Shen, Z., Ren, Y., Ye, D., Guo, J., Kang, C., & Ding, H. (2011). Significance and relationship between DJ-1 gene and survivin gene expression in laryngeal carcinoma. European Journal of Histochemistry, 55(1), e9. https://doi.org/10.4081/ejh.2011.e9

Similar Articles

<< < 45 46 47 48 49 50 

You may also start an advanced similarity search for this article.

Publication Facts

Metric
This article
Other articles
Peer reviewers 
2
2.4

Reviewer profiles  N/A

Author statements

Author statements
This article
Other articles
Data availability 
N/A
16%
External funding 
N/A
32%
Competing interests 
N/A
11%
Metric
This journal
Other journals
Articles accepted 
57%
33%
Days to publication 
155
145

Indexed in

Editor & editorial board
profiles
Academic society 
N/A