Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study

  • A. Santoro University of Foggia, Italy.
  • G. Pannone University of Foggia, Italy.
  • M.E. Errico Paediatric Oncological Hospital ‘Pausillipon’, Italy.
  • D. Bifano Paediatric Oncological Hospital ‘Pausillipon’, Napoli, Italy.
  • G. Lastilla University of Bari, Italy.
  • P. Bufo University of Foggia, Italy.
  • C. Loreto | carla.loreto@unict.it University of Catania, Italy.
  • V. Donofrio Paediatric Oncological Hospital ‘Pausillipon’, Napoli, Italy.

Abstract

Beta-catenin is a major protein in the Wnt signalling pathway. Although it has been studied in various types of carcinoma, little is known about its expression in mesenchymal tumours. In this study 41 specimens of a variety of mesenchymal childhood tumours were compared to 24 samples of the corresponding adult tumours to assess the diagnostic value of nuclear β-catenin expression using tissue microarray-based immunohistochemistry. Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority of childhood sarcomas, and its nuclear translocation was detected in paediatric fibromatosis; non-negligible levels of nuclear staining in other tumour types demonstrate Wnt pathway activation in mesenchymal neoplasms of childhood and adolescence.

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Author Biographies

A. Santoro, University of Foggia
Department of Surgical Sciences, Institute of Pathology and Cytopathology
G. Pannone, University of Foggia
Department of Surgical Sciences, Institute of Pathology and Cytopathology
M.E. Errico, Paediatric Oncological Hospital ‘Pausillipon’
Section of Pathological Anatomy
D. Bifano, Paediatric Oncological Hospital ‘Pausillipon’, Napoli
Section of Pathological Anatomy
G. Lastilla, University of Bari
Section of Anatomic Pathology ‘E.E. Franco’
P. Bufo, University of Foggia
Department of Surgical Sciences, Section of Anatomic Pathology and Cytopathology
C. Loreto, University of Catania
Department of Bio-Medical Sciences, Anatomy section
V. Donofrio, Paediatric Oncological Hospital ‘Pausillipon’, Napoli
Section of Pathological Anatomy
Published
2012-07-02
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Section
Original Papers
Keywords:
beta-catenin, Wnt-pathway, immunohistochemistry, paediatric mesenchymal tumors
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How to Cite
Santoro, A., Pannone, G., Errico, M., Bifano, D., Lastilla, G., Bufo, P., Loreto, C., & Donofrio, V. (2012). Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study. European Journal of Histochemistry, 56(3), e25. https://doi.org/10.4081/ejh.2012.e25