Original Papers
2 July 2012
Vol. 56 No. 3 (2012)
https://doi.org/10.4081/ejh.2012.e25

Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study

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beta-catenin, Wnt-pathway, immunohistochemistry, paediatric mesenchymal tumors
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Authors

A. Santoro
University of Foggia, Italy.
G. Pannone
University of Foggia, Italy.
M.E. Errico
Paediatric Oncological Hospital ‘Pausillipon’, Italy.
D. Bifano
Paediatric Oncological Hospital ‘Pausillipon’, Napoli, Italy.
G. Lastilla
University of Bari, Italy.
P. Bufo
University of Foggia, Italy.
C. Loreto
carla.loreto@unict.it
University of Catania, Italy.
V. Donofrio
Paediatric Oncological Hospital ‘Pausillipon’, Napoli, Italy.
Beta-catenin is a major protein in the Wnt signalling pathway. Although it has been studied in various types of carcinoma, little is known about its expression in mesenchymal tumours. In this study 41 specimens of a variety of mesenchymal childhood tumours were compared to 24 samples of the corresponding adult tumours to assess the diagnostic value of nuclear β-catenin expression using tissue microarray-based immunohistochemistry. Similar to adult sarcoma and fibromatosis, β-catenin was not expressed in the majority of childhood sarcomas, and its nuclear translocation was detected in paediatric fibromatosis; non-negligible levels of nuclear staining in other tumour types demonstrate Wnt pathway activation in mesenchymal neoplasms of childhood and adolescence.

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A. Santoro, University of Foggia
Department of Surgical Sciences, Institute of Pathology and Cytopathology
G. Pannone, University of Foggia
Department of Surgical Sciences, Institute of Pathology and Cytopathology
M.E. Errico, Paediatric Oncological Hospital ‘Pausillipon’
Section of Pathological Anatomy
D. Bifano, Paediatric Oncological Hospital ‘Pausillipon’, Napoli
Section of Pathological Anatomy
G. Lastilla, University of Bari
Section of Anatomic Pathology ‘E.E. Franco’
P. Bufo, University of Foggia
Department of Surgical Sciences, Section of Anatomic Pathology and Cytopathology
C. Loreto, University of Catania
Department of Bio-Medical Sciences, Anatomy section
V. Donofrio, Paediatric Oncological Hospital ‘Pausillipon’, Napoli
Section of Pathological Anatomy

How to Cite



1.
Santoro A, Pannone G, Errico M, Bifano D, Lastilla G, Bufo P, et al. Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study. Eur J Histochem [Internet]. 2012 Jul. 2 [cited 2025 Nov. 11];56(3):e25. Available from: https://www.ejh.it/ejh/article/view/ejh.2012.e25

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