Expression of parafibromin in major renal cell tumors

  • C. Cui Hospital of the University of Pennsylvania, United States.
  • P. Lal Hospital of the University of Pennsylvania, United States.
  • S. Master Hospital of the University of Pennsylvania, United States.
  • Y. Ma Hospital of the University of Pennsylvania, United States.
  • T. Baradet Hospital of the University of Pennsylvania, United States.
  • Z. Bing | bingz@uphs.upenn.edu Hospital of the University of Pennsylvania, United States.

Abstract

Parafibromin, encoded by HRPT2 gene, is a recently identified tumor suppressor. Complete and partial loss of its expression have been observed in hyperparathyroidism-jaw tumor (HPT-JT), parathyroid carcinoma, breast carcinoma, lung carcinoma, gastric and colorectal carcinoma. However, little has been known about its expression in renal tumors. In order to study the expression of parafibromin in a series of the 4 major renal cell tumors - clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), chromophobe renal cell carcinoma (chRCC) and oncocytoma. One hundred thirty nine renal tumors including 61 ccRCCs, 37 pRCCs, 22 chRCCs and 19 oncocytomas were retrieved and used for the construction of renal tissue microarrays (TMAs). The expression of parafibromin was detected by immunohistochemical method on the constructed TMAs. Positive parafibromin stains are seen in 4 out of 61 ccRCCs (7%), 7 out of 37 pRCCs (19%), 12 out of 23 chRCCs (52%) and all 19 oncocytomas (100%). Parafibromin expression varies significantly (P< 8.8 x10-16) among the four major renal cell tumors and were correlated closely with tumor types. No correlation of parafibromin expression with tumor staging in ccRCCs, pRCCs and chRCCs, and Fuhrman nuclear grading in ccRCCs and pRCCs. In summary, parafibromin expression was strongly correlated with tumor types, which may suggest that it plays a role in the tumorigenesis in renal cell tumors.

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Author Biographies

C. Cui, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
P. Lal, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
S. Master, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Y. Ma, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
T. Baradet, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Z. Bing, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Published
2012-10-23
Section
Original Papers
Supporting Agencies
None
Keywords:
Parafibromin, renal epithelial tumors
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How to Cite
Cui, C., Lal, P., Master, S., Ma, Y., Baradet, T., & Bing, Z. (2012). Expression of parafibromin in major renal cell tumors. European Journal of Histochemistry, 56(4), e39. https://doi.org/10.4081/ejh.2012.e39