@article{Porzionato_Macchi_Amagliani_Castagliuolo_Parenti_De Caro_2009, title={Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body}, volume={53}, url={https://www.ejh.it/ejh/article/view/ejh.2009.e16}, DOI={10.4081/ejh.2009.e16}, abstractNote={In the present study we investigated, through immunohistochemistry, the presence and location of neurotensin receptor 1 (NTR1) in the peripheral ganglia and carotid body of 16 humans and 5 rats. In both humans and rats, NTR1 immunostained ganglion cells were found in superior cervical ganglia (57.4±11.6% and 72.4±11.4%, respectively, p<0.05), enteric ganglia (51.9±10.4% and 64.6±6.1%, p<0.05), sensory ganglia (69.2±10.7% and 73.0±13.1%, p>0.05) and parasympathetic ganglia (52.1±14.1% and 59.4±14.0%, p>0.05), supporting a modulatory role for NT in these ganglia. Positivity was also detected in 45.6±9.2% and 50.8±6.8% of human and rat type I glomic cells, respectively, whereas type II cells were negative. Our findings suggest that NT produced by type I cells acts in an autocrine or paracrine way on the same cell type, playing a modulatory role on chemoception.}, number={3}, journal={European Journal of Histochemistry}, author={Porzionato, A. and Macchi, V. and Amagliani, A. and Castagliuolo, I. and Parenti, A. and De Caro, R.}, year={2009}, month={Sep.}, pages={e16} }