@article{Quirino_Pereira_Deodato de Souza_Pitta_da Silva Filho_Albuquerque_Albuquerque_Martins_Pitta_Rêgo_2021, title={Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters}, volume={65}, url={https://www.ejh.it/ejh/article/view/3174}, DOI={10.4081/ejh.2021.3174}, abstractNote={<p>The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types. The present study aimed to investigate Siglec-15 expression in gastric cancer (GC) patient tissue and to evaluate its clinical value. Siglec-15 expression was evaluated by immunohistochemistry with 71 patients. Siglec-15 staining was observed in tumor cells of 53 (74.64%) patients, with significant association with histologic classification and angiolymphatic invasion (p<0.05). Immunohistochemistry analysis also detected Siglec-15 in tumor-associated stroma cells (macrophages/myeloid cells). There was no significant association with outcomes parameters. Siglec-15 expression in well differentiated histological GC tissues and in the tumor microenvironment are potential targets to be further investigated as a novel prognostic factor for GC.</p>}, number={1}, journal={European Journal of Histochemistry}, author={Quirino, Michael Williams Leal and Pereira, Michelly Cristiny and Deodato de Souza, Maria de Fátima and Pitta, Ivan da Rocha and da Silva Filho, Antônio Felix and Albuquerque, Mario S. de Souza and Albuquerque, Amanda Pinheiro de Barros and Martins, Mário Rino and Pitta, Maira Galdino da Rocha and Rêgo, Moacyr Jesus Barreto de Melo}, year={2021}, month={Mar.} }