@article{Ventura_Boniotto_Pazienza_Palumbo_2009, title={Localization of b-defensin genes in non human primates}, volume={48}, url={https://www.ejh.it/ejh/article/view/888}, DOI={10.4081/888}, abstractNote={Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four b-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank accession number NM_005218); DEFB4 (h-Bd2, NM_004942.2), DEFB103 (h-BD3, NM_018661); and DEFB104 (hBD4, NM_080389) mapping on chromosome 8p23.22. We have localized b- defensin genes on metaphasic chromosomes of great apes and several non-human primate species to determine their physical mapping. Using fluorescent in situ hybridization and BAC probes containing the four b-defensin genes, we have mapped the homologous regions to the b-defensin genes on chromosome 8p23-p.22 in non-human primates, while no signals were detected on prosimians chromosomes.}, number={2}, journal={European Journal of Histochemistry}, author={Ventura, M and Boniotto, M and Pazienza, M and Palumbo, V}, year={2009}, month={Jun.}, pages={195–200} }