@article{Foglieni_Scabini_Belloni_Broccolo_Lusso_Malnati_Ferrero_2009, title={Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformation}, volume={49}, url={https://www.ejh.it/ejh/article/view/954}, DOI={10.4081/954}, abstractNote={Kaposi’s Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection.We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR upregulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS.}, number={3}, journal={European Journal of Histochemistry}, author={Foglieni, C and Scabini, S and Belloni, D and Broccolo, F and Lusso, P and Malnati, MS and Ferrero, E}, year={2009}, month={Jun.}, pages={273–284} }