TY - JOUR AU - Cappello, F AU - Bellafiore, M AU - Palma, A AU - Bucchieri, F PY - 2010/01/23 Y2 - 2024/03/28 TI - Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation JF - European Journal of Histochemistry JA - Eur J Histochem VL - 46 IS - 3 SE - Reviews DO - 10.4081/1680 UR - https://www.ejh.it/ejh/article/view/1680 SP - 199-208 AB - The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer. ER -