TY - JOUR AU - Malatesta, M. AU - Meola, G. PY - 2010/10/19 Y2 - 2024/03/28 TI - Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ JF - European Journal of Histochemistry JA - Eur J Histochem VL - 54 IS - 4 SE - Views and Comments DO - 10.4081/ejh.2010.e44 UR - https://www.ejh.it/ejh/article/view/ejh.2010.e44 SP - e44 AB - <span style="font-size: 12pt; font-family: Arial; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-GB; mso-fareast-language: IT; mso-bidi-language: AR-SA;" lang="EN-GB">The histochemical and ultrastructural analysis of the nuclear components involved in RNA transcription and splicing can reveal the occurrence of cellular dysfunctions eventually related to the onset of a pathological phenotype. In recent years, nuclear histochemistry at light and electron microscopy has increasingly been used to investigate the basic mechanisms of skeletal muscle diseases; the study in situ of nuclei of myofibres and satellite cells proved to be crucial for understanding the pathogenesis of skeletal muscle wasting in sarcopenia, myotonic dystrophy and laminopathies.<span style="mso-spacerun: yes;">&nbsp; </span></span> ER -