TY - JOUR AU - Musumeci, G. AU - Castrogiovanni, P. AU - Mazzone, V. AU - Szychlinska, M.A. AU - Castorina, S. AU - Loreto, C. PY - 2014/04/15 Y2 - 2024/03/29 TI - Histochemistry as a unique approach for investigating normal and osteoarthritic cartilage JF - European Journal of Histochemistry JA - Eur J Histochem VL - 58 IS - 2 SE - Reviews - 60th Anniversary EJH DO - 10.4081/ejh.2014.2371 UR - https://www.ejh.it/ejh/article/view/2371 SP - AB - <p>In this review article, we describe benefits and disadvantages of the established histochemical methods for studying articular cartilage tissue under normal, pathological and experimental conditions. We illustrate the current knowledge on cartilage tissue based on histological and immunohistochemical aspects, and in conclusion we provide a short overview on the degeneration of cartilage, such as osteoarthritis. Adult articular cartilage has low capacity to repair itself, and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, resulting in significant pain and disability. Numerous efforts have been made to implement the knowledge in the study of cartilage in the last years, and histochemistry proved to be an especially powerful tool to this aim.</p> ER -