TY - JOUR AU - Corlan, Ana Silvia AU - Cîmpean, Anca Maria AU - Melnic, Eugen AU - Raica, Marius AU - Sarb, Simona PY - 2019/03/05 Y2 - 2024/03/28 TI - VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas JF - European Journal of Histochemistry JA - Eur J Histochem VL - 63 IS - 1 SE - Original Papers DO - 10.4081/ejh.2019.3010 UR - https://www.ejh.it/ejh/article/view/3010 SP - AB - <p>Vascular endothelial growth factor (VEGF), its inhibitory splice variant, VEGF<em>165b </em>and Endocrine Gland derived VEGF (EG-VEGF) have a controversial role in pituitary gland. We aim to study VEGF, VEGF<em>165b</em> and EG-VEGF expression in pituitary adenomas. A significant correlation was found between growth hormone (GH) and VEGF secretion (P=0.024). For prolactinomas, VEGF and prolactin expression, had a P-value of 0.02 for Kendall coefficient and a P-value of 0.043 for the Spearman coefficient. VEGF-mRNA amplification was detected in both tumor cells and folliculostellate cells. VEGF<em>165b</em> was positive in 16.66% of pituitary adenomas. EG-VEGF was significantly correlated with prolactin (P=0.025) and luteinizing hormone (P=0.028). Our data strongly support VEGF, VEGF<em>165b</em> and EG-VEGF as important players of pituitary adenomas tumorigenesis. Particular hormonal milieu heterogeneity, special vascular network with an unusual reactivity to tumor growth correlated with variability of VEGF, VEGF<em>165b</em> and EG-VEGF secretion may stratify pituitary adenomas in several molecular groups with a direct impact on therapy and prognosis.</p> ER -