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DNA damage in acute myeloid leukemia patients of Northern Mexico

Martha I. Dávila-Rodríguez, Elva I. Cortés-Gutiérrez, Roberto Hernández-Valdés, Karla Guzmán-Cortés, Rosa E. De León-Cantú, Ricardo M. Cerda-Flores, Enrique Báez-De la Fuente
  • Elva I. Cortés-Gutiérrez
    Instituto Mexicano del Seguro Social, Mexico
  • Roberto Hernández-Valdés
    Instituto Mexicano del Seguro Social, Mexico
  • Karla Guzmán-Cortés
    Instituto Mexicano del Seguro Social, Mexico
  • Rosa E. De León-Cantú
    Instituto Mexicano del Seguro Social, Mexico
  • Ricardo M. Cerda-Flores
    Universidad Autónoma De Nuevo León, Mexico
  • Enrique Báez-De la Fuente
    Instituto Mexicano del Seguro Social, Mexico

Abstract

The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

Keywords

DNA damage; acute myeloid leukemia; DNA breakage detection-fluorescence in situ hybridization; Mexico.

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Submitted: 2017-09-14 02:43:27
Published: 2017-12-11 13:18:21
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Copyright (c) 2017 Martha I. Davila-Rodriguez, Elva I. Cortés-Gutiérrez, Roberto Hernández-Valdés, Karla Guzmán-Cortés, Rosa E. De León-Cantú, Ricardo M. Cerda-Flores, Enrique Báez-De la Fuente

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