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Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract

S. Nemolato, T. Cabras, M.U. Fanari, F. Cau, D. Fanni, C. Gerosa, B. Manconi, I. Messana, M. Castagnola, G. Faa
  • T. Cabras
    UniversitÓ di Cagliari, Italy
  • M.U. Fanari
    UniversitÓ di Cagliari, Italy
  • F. Cau
    UniversitÓ di Cagliari, Italy
  • D. Fanni
    UniversitÓ di Cagliari, Italy
  • C. Gerosa
    UniversitÓ di Cagliari, Italy
  • B. Manconi
    UniversitÓ di Cagliari, Italy
  • I. Messana
    UniversitÓ di Cagliari, Italy
  • M. Castagnola
    UniversitÓ Cattolica Roma, Italy
  • G. Faa
    UniversitÓ di Cagliari, Italy

Abstract

Thymosins beta 4 (T╬▓4) is a member of the beta-thymosins family, a family of peptides playing essential roles in many cellular functions. Our recent studies suggested T╬▓4 plays a key role in the development of human salivary glands and the gastrointestinal tract. The aim of this study was to analyse the presence of T╬▓4 in the human adult and foetal genitourinary tract. Immunolocalization of T╬▓4 was studied in autoptic samples of kidney, bladder, uterus, ovary, testicle and prostate obtained from four human foetuses and four adults. Presence of the peptide was observed in cells of different origin: in surface epithelium, in gland epithelial cells and in the interstitial cells. T╬▓4 was mainly found in adult and foetal bladder in the transitional epithelial cells; in the adult endometrium, glands and stromal cells were immunoreactive for the peptide; T╬▓4 was mainly localized in the glands of foetal prostate while, in the adults a weak T╬▓4 reactivity was restricted to the stroma. In adult and foetal kidney, T╬▓4 reactivity was restricted to ducts and tubules with completely spared glomeruli; a weak positivity was observed in adult and foetal oocytes; immunoreactivity was mainly localized in the interstitial cells of foetal and adult testis. In this study, we confirm that T╬▓4 could play a relevant role during human development, even in the genitourinary tract, and reveal that immunoreactivity for this peptide may change during postnatal and adult life.

Keywords

Thymosin ?4, genitourinary tract, development

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Submitted: 2010-07-16 09:19:08
Published: 2010-10-13 16:38:26
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Copyright (c) 2010 S. Nemolato, T. Cabras, M.U. Fanari, F. Cau, D. Fanni, C. Gerosa, B. Manconi, I. Messana, M. Castagnola, G. Faa

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