Expression of parafibromin in major renal cell tumors

Submitted: 26 April 2012
Accepted: 29 June 2012
Published: 23 October 2012
Abstract Views: 978
PDF: 447
HTML: 213
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Parafibromin, encoded by HRPT2 gene, is a recently identified tumor suppressor. Complete and partial loss of its expression have been observed in hyperparathyroidism-jaw tumor (HPT-JT), parathyroid carcinoma, breast carcinoma, lung carcinoma, gastric and colorectal carcinoma. However, little has been known about its expression in renal tumors. In order to study the expression of parafibromin in a series of the 4 major renal cell tumors - clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), chromophobe renal cell carcinoma (chRCC) and oncocytoma. One hundred thirty nine renal tumors including 61 ccRCCs, 37 pRCCs, 22 chRCCs and 19 oncocytomas were retrieved and used for the construction of renal tissue microarrays (TMAs). The expression of parafibromin was detected by immunohistochemical method on the constructed TMAs. Positive parafibromin stains are seen in 4 out of 61 ccRCCs (7%), 7 out of 37 pRCCs (19%), 12 out of 23 chRCCs (52%) and all 19 oncocytomas (100%). Parafibromin expression varies significantly (P< 8.8 x10-16) among the four major renal cell tumors and were correlated closely with tumor types. No correlation of parafibromin expression with tumor staging in ccRCCs, pRCCs and chRCCs, and Fuhrman nuclear grading in ccRCCs and pRCCs. In summary, parafibromin expression was strongly correlated with tumor types, which may suggest that it plays a role in the tumorigenesis in renal cell tumors.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Supporting Agencies

None
C. Cui, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
P. Lal, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
S. Master, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Y. Ma, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
T. Baradet, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Z. Bing, Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine

How to Cite

Cui, C., Lal, P., Master, S., Ma, Y., Baradet, T., & Bing, Z. (2012). Expression of parafibromin in major renal cell tumors. European Journal of Histochemistry, 56(4), e39. https://doi.org/10.4081/ejh.2012.e39