Reviews
Vol. 46 No. 3 (2002)
https://doi.org/10.4081/1680

Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 23 January 2010
Accepted: 23 January 2010
Published: 23 January 2010
773
Views
893
Downloads

Authors

F Cappello
support@pagepress.org
PAGEPress Office, Pavia, Italy.
M Bellafiore
A Palma
F Bucchieri
The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer.

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite



1.
Cappello F, Bellafiore M, Palma A, Bucchieri F. Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation. Eur J Histochem [Internet]. 2010 Jan. 23 [cited 2026 Jan. 23];46(3):199-208. Available from: https://www.ejh.it/ejh/article/view/1680