https://doi.org/10.4081/ejh.2010.e7

Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney

Vol. 54 No. 1 (2010)
Submitted: 12 January 2010
Accepted: 12 January 2010
Published: 8 February 2010
KCNQ1 K channel, Rana esculenta, frog kidney, immunohistochemistry
Abstract Views: 865
PDF: 359
HTML: 3591
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

S. Ćirović
University of Belgrade, .
J. Marković-Lipkovski
acal@matf.bg.ac.rs
University of Belgrade, .
J. Todorović
University of Belgrade, .
J. Nešović-Ostojić
University of Belgrade, .
M. Jović
Military Medical Academy, Belgrade, .
S. Ilić
Military Medical Academy, Belgrade, .
S. Tatić
University of Belgrade, .
D. Čemerikić
University of Belgrade, .
The aim of this study was to evaluate KCNQ1 K+ channel expression in the frog kidney of Rana esculenta. KCNQ1 K+ channel, also known as KvLQT1, is the pore forming a-subunit of the IKs K+ channel, a delayed rectifier voltage-gated K+ channel, which has an important role in water and salt transport in the kidney and gastrointestinal tract. The expression of KCNQ1 K+ channel along tubular epithelium differs from species to species. In the present study the expression of KCNQ1 K+ channel in the frog kidney has been demonstrated by immunohistochemistry. The presence of KCNQ1 K+ channel was demonstrated in the epithelial cells of distal convoluted tubule and collecting duct. However, the pattern of expression of KCNQ1 K+ channel differs between distal convoluted tubules and collecting duct. All epithelial cells of distal convoluted tubules revealed basolateral expression of KCNQ1 K+ channel. On the contrary, only the single cells of collecting duct, probably intercalated cells, showed diffuse cell surface staining with antibodies against KCNQ1 K+ channel. These findings suggest that KCNQ1 K+ channel has cell-specific roles in renal potassium ion transport.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

Ministry of Science and Technological Development of the Republic of Serbia.
J. Marković-Lipkovski, University of Belgrade
Institute of Pathology, Faculty of Medicine

How to Cite

Ćirović, S., Marković-Lipkovski, J., Todorović, J., Nešović-Ostojić, J., Jović, M., Ilić, S., Tatić, S., & Čemerikić, D. (2010). Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney. European Journal of Histochemistry, 54(1), e7. https://doi.org/10.4081/ejh.2010.e7

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.