Fluorescent RT in situ PCR detection of MRP1 mRNA in human HCV infected liver

  • L Pascolo | support@pagepress.org PAGEPress Office, Pavia, Italy.
  • S Bogoni
  • A Spanò
  • E Demori
  • A Amoroso
  • S Crovella


Chronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. Approximately 20% of cases of acute viral hepatitis are due to hepatitis C. Cirrhosis develops in more than 25% of patients with chronic infection and each year hepatocellular carcinoma occurs in 1-3% of patients with cirrhosis due to HCV (Hoofnagle 1999). Patients with hepatocellular carcinoma are characterized by nonresponsiveness to chemotherapeutic agents. A cause of refractivity to treatment has been ascribed to the overexpression of the Pgp (MDR) protein (Kim et al. 1999), and the additional involvement of multidrug resistance-associated proteins (MRPs) has been also hypothesized (Minemura et al. 1999).


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How to Cite
Pascolo, L., Bogoni, S., Spanò, A., Demori, E., Amoroso, A., & Crovella, S. (2009). Fluorescent RT in situ PCR detection of MRP1 mRNA in human HCV infected liver. European Journal of Histochemistry, 45(1), 105-8. https://doi.org/10.4081/1620