Fluorescent RT in situ PCR detection of MRP1 mRNA in human HCV infected liver
AbstractChronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. Approximately 20% of cases of acute viral hepatitis are due to hepatitis C. Cirrhosis develops in more than 25% of patients with chronic infection and each year hepatocellular carcinoma occurs in 1-3% of patients with cirrhosis due to HCV (Hoofnagle 1999). Patients with hepatocellular carcinoma are characterized by nonresponsiveness to chemotherapeutic agents. A cause of refractivity to treatment has been ascribed to the overexpression of the Pgp (MDR) protein (Kim et al. 1999), and the additional involvement of multidrug resistance-associated proteins (MRPs) has been also hypothesized (Minemura et al. 1999).
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Copyright (c) 2009 L Pascolo, S Bogoni, A SpanÃ², E Demori, A Amoroso, S Crovella
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