Nuclear localization of phosphorylated c-Myc protein in human tumor cells.

  • C. Soldani | pelli@unipv.it
  • M.G. Bottone
  • M. Biggiogera
  • C. Alpini
  • A.I. Scovassi
  • T. Martin
  • C. Pellicciari

Abstract

Using immunocytochemical techniques at light and electron microscopy, we analysed the distribution of phosphorylated c-Myc in actively proliferating human HeLa cells. The distribution pattern of c-Myc was also compared with those of other ribonucleoprotein (RNP)-containing components (PANA, hnRNP-core proteins, fibrillarin) or RNP-associated nuclear proteins (SC-35 splicing factor). Our results provide the first evidence that phosphorylated c-Myc accumulates in the nucleus of tumor cells, where it colocalizes with fibrillarin, both in the nucleolus and in extranucleolar structures.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2010-05-14
Info
Issue
Section
Letters to the Editor
Keywords:
c-Myc, fibrillarin, fluorescence microscopy, immunocytochemistry, nuclear bodies, nucleolus
Statistics
  • Abstract views: 500

  • PDF: 528
How to Cite
Soldani, C., Bottone, M., Biggiogera, M., Alpini, C., Scovassi, A., Martin, T., & Pellicciari, C. (2010). Nuclear localization of phosphorylated c-Myc protein in human tumor cells. European Journal of Histochemistry, 46(4), 377-80. https://doi.org/10.4081/1750

Most read articles by the same author(s)

1 2 > >>