The hypothalamic magnocellular neurosecretory system in developing rats

Submitted: 28 December 2009
Accepted: 28 December 2009
Published: 28 December 2009
Abstract Views: 578
PDF: 641
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Studies concerning the development of the magnocellular system are scarce and discordant in literature. We carried out an immunohistochemical study on supraotic and paraventricular hypothalamic nuclei using antivasopressin and antioxytocin antibodies in developing rats between the 15th day of intrauterine life and the 6th day of postnatal life. In addition, we performed RT-PCR experiments to establish the stage at which these hormones appear and neurosecretory activity commences. The results showed that supraoptic and paraventricular nuclei appear, respectively, on the 16th and the 18th day of intrauterine life and both immediately synthetize vasopressin neurohormone. By contrast, synthesis of oxytocin takes place from the 2nd day after birth. Probably, these nuclei synthetize oxytocin in conjunction with the decline of placental maternal oxytocin.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Farina Lipari, E., Lipari, D., Gerbino, A., Di Liberto, D., Bellafiore, M., Catalano, M., & Valentino, B. (2009). The hypothalamic magnocellular neurosecretory system in developing rats. European Journal of Histochemistry, 45(2), 163–8. https://doi.org/10.4081/1626