Brief Reports
Vol. 70 No. 4 (2026)
https://doi.org/10.4081/ejh.2026.4584

Telocytes are associated with uterine remodeling during pregnancy in Kyrgyz mares

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Published: 3 November 2026
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Morphometric, uterus, Kyrgyz, mare, telocytes, pregnancy

Authors

Ali Risvanli
ali.risvanli@manas.edu.kg
Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
Ruslan Salykov
Faculty of Veterinary Medicine, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan.
Necati Timurkaan
Faculty of Veterinary Medicine, Firat University, Elazığ, Türkiye.
Ibrahim Seker
Faculty of Veterinary Medicine, Firat University, Elazığ, Türkiye.
Elif Ekinci
Faculty of Veterinary Medicine, Dicle University, Diyarbakır, Türkiye.
Ilkhomjon Sobirov Abdullayevich
Andijan Institute of Agriculture and Agrotechnologies, Andijan, Uzbekistan.

The relationship between telocytes and the changes occurring in the morphometric structure of the uterus during pregnancy has not yet been sufficiently clarified. This study was conducted to evaluate the relationship between pregnancy-related morphometric changes in the uteri of Kyrgyz mares and telocyte counts. A total of 53 mares, both pregnant and non-pregnant, aged 2-6 months, were examined; uterine tissues were analyzed using light microscopy and immunohistochemical methods. In general, a positive relationship was found between gland density and telocyte count, while in non-pregnant mares, this relationship was found to be inversely and significantly correlated. A negative correlation between gland diameter and telocyte count was detected in many groups, particularly in the 5-month pregnancy group. Furthermore, a positive correlation was found between endometrial thickness and both myometrial and total telocyte counts in 6-month pregnant mares. Consequently, it is thought that telocytes are associated with structural changes in the uterus during pregnancy and may play an important role in the remodeling and functional adaptation of the uterus, particularly in the later stages of pregnancy.

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Scopus
Google Scholar
Europe PMC
1. Abd-Elhafeez HH, Soliman SA. New description of telocyte sheaths in the bovine uterine tube: An immunohistochemical and scanning microscopic study. Cells Tissues Organs 2017;203:295-315. DOI: https://doi.org/10.1159/000452243
2. Al-Zahraa AF, Mahmoud ES, ElNabawy RM. Uterine rat telocyte structure and organization: An immunohistochemical and ultrastructural study. Egypt J Histol 2023;46:1342-52.
3. Babadag S, Çelebi-Saltik B. A cellular regulator of the niche: Telocyte. Tissue Barriers 2023;11:2131955. DOI: https://doi.org/10.1080/21688370.2022.2131955
4. Campeanu RA, Radu BM, Cretoiu SM, Banciu DD, Banciu A, Cretoiu D, et al. Near-infrared low-level laser stimulation of telocytes from human myometrium. Lasers Med Sci 2014;29:1867-74. DOI: https://doi.org/10.1007/s10103-014-1589-1
5. Cretoiu D, Ciontea SM. Popescu LM, Ceafalan L, Ardeleanu C. Interstitial Cajal-like cells as steroid hormone sensors in human myometrium: Immunocytochemical approach. J Cell Mol Med 2006;10:789-95. DOI: https://doi.org/10.1111/j.1582-4934.2006.tb00438.x
6. Roatesi I, Radu BM, Cretoiu D, Cretoiu SM. Uterine telocytes: A review of current knowledge. Biol Reprod 2015:93;10. DOI: https://doi.org/10.1095/biolreprod.114.125906
7. Klein M, Csöbönyeiová M, Danišovič Ľ, Lapides L, Varga I. Telocytes in the female reproductive system: Up-to-date knowledge, challenges and possible clinical applications. Life 2022;12:267. DOI: https://doi.org/10.3390/life12020267
8. Schoon HA, Schoon D, Wiegandt I, Bartmann CP, Aupperle H. Endometrial maldifferentiation - A clinically significant diagnosis in equine reproduction? Pferdeheilkunde 1999;15:555-9. DOI: https://doi.org/10.21836/PEM19990613
9. Schoon HA, Wiegandt I, Schoon D, Aupperle H, Bartmann CP. Functional disturbances in the endometrium of barren mares: A histological and immunohistological study. J Reprod Fertil Suppl 2000;56:381-91.
10. Gray CA, Taylor KM, Ramsey WS, Hill JR, Bazer FW, Bartol FF, et al. Endometrial glands are required for preimplantation conceptus elongation and survival. Biol Reprod 2001;64:1608-13. DOI: https://doi.org/10.1095/biolreprod64.6.1608
11. Silva ESM, Leite RO, Maciel LFS, Francia C, Padovani CR, Oliveira-Filho JP, et al. Endometrial histomorphometry of anestrous mares under the influence of different embryo transfer hormonal protocols. J Equine Vet Sci 2019;81:102792. DOI: https://doi.org/10.1016/j.jevs.2019.102792
12. Risvanli A, Salykov R, Timurkaan N, Seker I, Ekinci E. Changes in uterine glandular histology in Kyrgyz breed mares according to pregnancy status. Anat Histol Embryol 2026;55:e70078. DOI: https://doi.org/10.1111/ahe.70078
13. Klein M, Urban L, Deckov I, Danisovic S, Polak S, Danihel L, et al. Distribution of telocytes in the corpus and cervix of human uterus. Biologia 2017;72:1217-23. DOI: https://doi.org/10.1515/biolog-2017-0134
14. Othman ER, Elgamal DA, Refaiy AM, Abdelaal II, Abdel-Mola AF, Al-Hendy A. Identification and potential role of telocytes in human uterine leiomyoma. Contracept Reprod Med 2016;1:12. DOI: https://doi.org/10.1186/s40834-016-0022-5
15. Urban L, Miko M, Kajanova M, Bozikova S, Mrazova H, Varga I. Telocytes (interstitial Cajal-like cells) in human fallopian tubes. Bratisl Med J 2016;117:263-7. DOI: https://doi.org/10.4149/BLL_2016_051
16. Varga I, Kyselovič J, Danišovič Ľ, Gálfiová P, Kachlík D, Polák Š, et al. Recently discovered interstitial cells termed telocytes: Distinguishing cell-biological and histological facts from fictions. Biologia 2019;74:195-203. DOI: https://doi.org/10.2478/s11756-018-0162-y
17. Salama NM. Immunohistochemical characterization of telocytes in rat uterus in different reproductive states. Egypt J Histol 2013;36:185-94. DOI: https://doi.org/10.1097/01.EHX.0000425654.68291.c8
18. Risvanli A, Hatipoglu F, Salykov R, Timurkaan N, Kadiralieva N, Kasymalieva KK, et al. Evaluation of telocytes in the ovary, oviduct, and uterus of Kyrgyz mares according to pregnancy status. Anat Histol Embryol 2025;54:e70024. DOI: https://doi.org/10.1111/ahe.70024
19. Akgül A. Statistical analysis techniques in medical research. Ankara, Yök Publications; 1997.
20. Özdamar, K. Biostatistics with SPSS, 5th ed. Ankara, Kaan Press; 2003.
21. Cretoiu SM, Cretoiu D, Simionescu A, Popescu LM. Telocytes in human fallopian tube and uterus express estrogen and progesterone receptors. Sex Steroid 2012;217:114-20.
22. Cretoiu SM, Radu BM, Banciu A, Banciu DD, Cretoiu D, Ceafalan LC, et al. Isolated human uterine telocytes: Immunocytochemistry and electrophysiology of T-type calcium channels. Histochem Cell Biol 2015;143:83-94. DOI: https://doi.org/10.1007/s00418-014-1268-0
23. Soliman SA, Abd-Elhafeez HH, Abou-Elhamd AS, Kamel BM, Abdellah N, Mustafa FEZA. Role of uterine telocytes during pregnancy. Microsc Microanal 2023;29:283-302. DOI: https://doi.org/10.1093/micmic/ozac001
24. Tang XL, Zhang FL, Jiang XJ, Yang XJ. Telocytes enhanced the proliferation, adhesion and motility of endometrial stromal cells as mediated by the ERK pathway in vitro. Am J Transl Res 2019;11:572-85.
25. Banciu A, Banciu DD, Mustaciosu CC, Radu M, Cretoiu D, Xiao J, et al. Beta-estradiol regulates voltage-gated calcium channels and estrogen receptors in telocytes from human myometrium. Int J Mol Sci 2018;19:1413. DOI: https://doi.org/10.3390/ijms19051413
26. Aleksandrovych V, Walocha JA, Gil K. Telocytes in female reproductive system (human and animal). J Cell Mol Med 2016;20:994-1000. DOI: https://doi.org/10.1111/jcmm.12843
27. Cretoiu SM, Cretoiu D, Marin A, Radu BM, Popescu LM. Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium. Reproduction 2013;145:357-70. DOI: https://doi.org/10.1530/REP-12-0369

Ethics Approval

The experimental protocols were reviewed and approved by the Kyrgyzstan-Turkey Manas University Animal Ethics Committee

CRediT authorship contribution

Ali Risvanli, conceptualization, funding acquisition, methodology, investigation, formal analysis, visualization, writing - original draft. Ruslan Salykov, conceptualization, data curation, software. Necati Timurkaan, resources, supervision, validation. Ibrahim Seker, methodology, investigation. Elif Ekinci, conceptualization, formal analysis, writing - review & editing. Ilkhomjon Sobirov Abdullayevich, funding acquisition, resources, supervision

Data Availability Statement

The data supporting the findings of this study are available from the corresponding author upon reasonable request.

How to Cite



1.
Risvanli A, Salykov R, Timurkaan N, Seker I, Ekinci E, Abdullayevich IS. Telocytes are associated with uterine remodeling during pregnancy in Kyrgyz mares. Eur J Histochem [Internet]. 2026 Nov. 3 [cited 2026 Nov. 6];70(4). Available from: https://www.ejh.it/ejh/article/view/4584
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