17th International Conference of Histochemistry and Cytochemistry, 2025

All Items

P61 | IMMUNOPROFILE OF MERKEL CELLS IN THE HUMAN VAGINAL EPITHELIUM S. Polakovičová¹, M. Borovský², L. Maršík², B. Filová³, I. Varga³, L. Sallicandro⁴ | ¹Inst. of Hist. and Embr. MFCU in Bratislava, Bratislava, Slovakia; ²1st Obst. and Gyn. Dep. FMCU with Repr. Med. Centre Hospital, Bratislava, Slovakia; ³Inst. of Hist. and Embr. MFCU in Bratislava, Bratislava, Slovakia; ⁴Dep. of Medicine and Surgery, University of Perugia, Perugia, Italy

https://doi.org/10.4081/ejh.2025.4386

263

P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante¹, L. Leanza², E. Guerra³, F. Vianello⁴, C. Iacovino¹, S. Lattanzio¹, L. Morello¹, G. Stati¹, P. Simeone³, P. Lanuti³, S. Alberti⁵, M. Reichert⁶, R. Di Pietro¹ | ¹Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Biology, University of Padua, Padua, Italy; ³Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; ⁴Department of Biology, University of Padua, Padua, Italy; ⁵Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; ⁶Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany

https://doi.org/10.4081/ejh.2025.4348

206

IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

https://doi.org/10.4081/ejh.2025.4316

291

ROLE OF SCHWANN CELLS-CANCER CELLS CROSSTALK IN TUMOUR PROGRESSION C. Giampietri¹, E. Pizzichini¹, F. Somma¹, S. Petrungaro¹, A. Facchiano², A. Filippini¹, C. Fabrizi¹, E. Gaudio¹ | ¹Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; ²Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy

https://doi.org/10.4081/ejh.2025.4276

203

P62 | FFAR4/GPR120 ACTIVATION COUNTERACTS FIBROGENIC PATHWAYS IN A CHOLESTATIC LIVER INJURY MODEL S. Pompili¹, R. Sferra¹, F. Ronca¹, A. Cappariello², A. Vetuschi¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; ²Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

https://doi.org/10.4081/ejh.2025.4387

300

P29 | GLUTAMATERGIC MODULATION OF HYPOTHALAMIC RSPONDIN3 NEURONS UNDER PHYSIOLOGICAL CONDITIONS D. Gok Yurtseven¹, G. Topal¹, N. Hasanoglu Akbulut², D. Udum³, M. Yalcın⁴, O. Eyigor¹ | ¹Department of Histology and Embryology, Bursa Uludag University, Faculty of Medicine, Bursa, Türkiye; ²Department of Histology and Embryology, Canakkale Onsekiz, Mart University, Faculty of Medicine, Canakkale, Türkiye; ³Department of Biochemistry, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Türkiye; ⁴Department of Veterinary Physiology, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Türkiye

https://doi.org/10.4081/ejh.2025.4349

195

THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

https://doi.org/10.4081/ejh.2025.4317

255

CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti¹, V. Serafin¹, L. Antolini¹, S. Bresolin², L. Reggiani Bonetti³, S. Marmiroli¹ | ¹Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ²Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; ³Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy

https://doi.org/10.4081/ejh.2025.4277

211

P63 | ROLE OF ION CYCLOTRON RESONANCE ON BODY ELECTRICAL IMPEDANCE IN CHRONIC PAIN: CLINICAL EFFECTS AND FUTURE PERSPECTIVES L. Prosperi¹, G. Barassi1, M. Panunzio², P. Spaggiari³, P.E. Gallenga¹ | ¹Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Responsible Research Hospital, Campobasso, Italy; ³Scientific Association of Integrated Biochemical and Biophysical Medicine (A.M.B.B.), Mantova, Italy

https://doi.org/10.4081/ejh.2025.4388

893

P30 | NEW INSIGHT IN THE IN VITRO-GENERATION OF INSULIN-PRODUCING CELLS: VAV1 AS A REGULATOR OF PDX1 AND MIR-375 LEVELS DURING DIFFERENTIATION OF HIPSCS INTO Β-CELLS M. Pierantoni¹, F. Brugnoli¹, V. Zamarian², M. Dell’Aira¹, V. Sordi², V. Bertagnolo¹, S. Grassilli³ | ¹Department of Translational Medicine, University of Ferrara, Ferrara, Italy; ²Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; ³Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4350

182

NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

https://doi.org/10.4081/ejh.2025.4318

337

FILAMIN A IN BREAST CANCER: FROM LITERATURE TO FUNCTIONAL INSIGHTS P. Zawadka¹, W. Arendt¹, M. Gagat^1,2, M. Izdebska¹ | ¹Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. ²Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland

https://doi.org/10.4081/ejh.2025.4278

196

P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri¹, M.V. Marvi¹, V. Righi², V. Papa³, E. Boschetti¹, S. Blando¹, E. Franceschi⁴, M. Zoli⁴, D. Mazzatenta⁴, N. Neri⁴, A. Vignaroli⁴, L. Cocco¹, L. Manzoli¹, S. Ratti¹ | ¹Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ²Department of Life Quality Sciences, University of Bologna, Bologna, Italy; ³IRCCS St. Orsola, Bologna, Italy; ⁴IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4389

342

P31 | MORPHOLOGICAL AND ULTRASTRUCTURAL MARKERS OF RADIATION-INDUCED ADIPOSE TISSUE DAMAGE E. Guerra¹, S. Lattanzio¹, G. Furini², G. Scabia², E. Mota-Silva², M. Maffei², S. Cinti³, R. Di Pietro¹ | ¹Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²CNR Institute of Clinical Physiology, Pisa, Italy; ³Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche (Polytechnic University of Marche), Ancona, Italy

https://doi.org/10.4081/ejh.2025.4351

204

EXPLORING THE CYTOTOXIC AND APOPTOTIC ACTIVITIES OF PRUNUS SPINOSA ECOTYPE EXTRACT TRIGNO ON 3D AND 2D MODELS OF HUMAN CANCER CELLS A. Di Netta¹, A. Di Pauli², R. Vona³, C. Cittadini³, S. Meschini¹, M. Condello¹ | ¹ National Center for Drug Research and Evaluation, National Institute of Health, Rome, Italy; ² Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, «Sapienza» University of Rome, Rome, Italy: ³ National Center for Gender-Specific Medicine, National Institute of Health, Rome, Italy

https://doi.org/10.4081/ejh.2025.4319

317

FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy

https://doi.org/10.4081/ejh.2025.4279

200

P65 | (YS) INVESTIGATING THE EFFECTS OF THE SECRETOME FROM HUMAN AMNIOTIC MESENCHYMAL STROMAL CELLS ON INFLAMMASOME ACTIVATION M. Rossi¹, M. Magatti², P. Romele², E. Vertua², E. Giuzzi², S. Farigu², L. Marelli², B. Rapuzzi², S. De Munari², A. Silini², O. Parolini³ | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, and Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; ²Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; ³Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy & Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy

https://doi.org/10.4081/ejh.2025.4390

282

P32 | BLOCKING CANCER CELL MOVEMENT: THE ROLE OF PAXILLIN AND EZRIN IN CERVICAL TUMOR M. Hałas-Wiśniewska¹, W. Arendt¹, M. Gagat^1,2, M. Izdebska¹ | ¹Department of Histology and Embryology, Nicolaus Copernicus University in Toruń, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Poland; ²Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

https://doi.org/10.4081/ejh.2025.4352

191

BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL V. Panella¹, F. De Cecco², S. Franceschelli¹, M. A. Maggi³, S. Bisti⁴, A. Bravo Nuevo⁵, D. D’Ardes¹, F. Cipollone¹, L. Speranza¹ | ¹Department of Medicine and Aging Sciences, University «G. D’Annunzio», Chieti; ²Italian Institute of Technology, Genoa, Italy; ³Hortus Novus, L’Aquila, Italy; ⁴National Institute of Biostructure and Biosystem, Rome, Italy; ⁵Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, USA

https://doi.org/10.4081/ejh.2025.4320

317

PATHOMICS – A NOVEL OMICS APPROACH FOR HISTOPATHOLOGY P. Boor^1,2 | ¹Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany; ²Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany

https://doi.org/10.4081/ejh.2025.4284

199

P66 | FROM INNERVATION TO STEROIDOGENIC DEFECT: IMPLICATIONS OF CGRP IN THE PATHOPHYSIOLOGY OF POLYCYSTIC OVARY SYNDROME L. Sallicandro¹, R. Gentile², B. Filová³, S. Polakovičová³, A. Biagini¹, F. Ballarino⁴, D. Del Bianco⁴, I. Varga⁵, A. Malvasi⁶, B. Fioretti² | ¹Department of Medicine and Surgery, University of Perugia, Perugia, Italy; ²Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; ³Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; ⁴Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; ⁵Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; ⁶Department of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Unit, University of Bari Aldo Moro, Bari, Italy

https://doi.org/10.4081/ejh.2025.4391

348

P33 | IMPACT OF CYCLIN C EXPRESSION ON THE AGGRESSIVENESS OF A549 NON-SMALL CELL LUNG CANCER CELLS V. Havryliuk | Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland

https://doi.org/10.4081/ejh.2025.4353

197

P01 | PUTATIVE EFFECTS OF THE HYDROGEL-STEM CELL-MELATONIN COMBINATION WITH OR WITHOUT A SCAFFOLD TO TREAT THIOACETAMIDE-INDUCED LIVER DEGENERATION IN RAT G. Ozgun¹, D. Yucel², M. Kolgazi³, S. Ozer⁴, N. Tozun⁵, S. Arbak⁶ | ¹Dept of Medical Biotechnology, Institute of health sciences, Acibadem Univ, Istanbul, Türkiye; ²Dept. of Histology and Embryology, School of Medicine, Acibadem Univ, Istanbul, Türkiye; ³Dept. of Physiology, School of Medicine, Acibadem Univ., Istanbul, Türkiye; ⁴Animal Application and Research Center, Acibadem Univ. Istanbul, Türkiye; ⁵Dept. of Gastroenterology, School of Medicine, Acibadem Univ., Istanbul, Türkiye; ⁶Dept. of Histology and Embryology, School of Medicine, Acibadem Univ., Istanbul, Türkiye

https://doi.org/10.4081/ejh.2025.4321

210

ACCELERATING DISCOVERY TOGETHER: A COMMUNITY APPROACH TO ANTIBODY VALIDATION AND MULTIPLEXED IMAGING A. Radtke | Leica Microsystems

https://doi.org/10.4081/ejh.2025.4285

189

P67 | EMERGING ROLE OF NUCLEAR PHOSPHOLIPASE C BETA 1 AS POTENTIAL BIOMARKER IN LUNG CANCER S. Salucci¹, I. Versari¹, S. Burattini², D. Montecchio³, I. Faenza¹ | ¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; ²Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4392

288

P34 | ADJUDIN-INDUCED MODEL IN RATS REVEALS HIPPO SIGNALING PATHWAY ACTIVITY IN THE TESTIS İ. İnanç¹, O. Bender², A. Atalay², E. Erdemli¹ | ¹Ankara University, Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye; ²Ankara University, Biotechnology Institute, Ankara, Türkiye

https://doi.org/10.4081/ejh.2025.4354

358

P02 | THE C-C CHEMOKINE-RECEPTOR 2 (CCR2)/CCL2 AXIS PARTICIPATE IN PLATELET FUNCTION IN MYELOFIBROSIS F. Arciprete¹, V. Velardi¹, G. Pozzi², C. Carubbi³, S. Cortellazzi³, A.M. Vannucchi⁴, M. Vitale⁵, R.A. Rana¹, G. Vivacqua¹, E. Masselli³, M. Zingariello¹ | ¹Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; ²Anatomy Unit, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy; ³Anatomy Unit, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy; ⁴Center Research and Innovation of Myeloproliferative Neoplasm, University Hospital Careggi, University of Florence, Florence, Italy; ⁵San Raffaele University, Milano, Italy

https://doi.org/10.4081/ejh.2025.4322

244

ANIMAL MODELS FOR LINEAGE TRACING IN (CELL) TRANSDIFFERENTIATION S. Cinti | Center for The Study of Obesity. Marche Polytechnic University, Ancona, Italy

https://doi.org/10.4081/ejh.2025.4286

168

P68 | EARLY EFFECTS OF MECHANOACUSTIC FOCUSED VIBRATION (MFV) ON PRIMARY HUMAN SATELLITE CELLS ISOLATED FROM YOUNG AND OLDER INDIVIDUALS S. Sancilio¹, G. Stati¹, E.S. Di Filippo², S. Fulle², R. Di Pietro¹ | ¹Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Neuroscience Imaging and Clinical Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy

https://doi.org/10.4081/ejh.2025.4393

267

P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES İ. İnanç¹, E. Baysal¹, O. Bender², A. Atalay², E. Erdemli¹ | ¹Ankara University, Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye; ²Ankara University, Biotechnology Institute, Ankara, Türkiye

https://doi.org/10.4081/ejh.2025.4355

173

P03 | THE ROLE OF FILAMIN A IN REGULATING BREAST CANCER CELL BEHAVIOR AND TUMOR MICROENVIRONMENT INTERACTIONS W. Arendt¹, P. Zawadka¹, M. Hałas-Wiśniewska¹, M. Gagat², M. Izdebska¹ | ¹ Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń, Poland; ²Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

https://doi.org/10.4081/ejh.2025.4323

197

ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS S. Alberti | University of Messina, Messina, Italy

https://doi.org/10.4081/ejh.2025.4287

188

P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo¹, V. Gallicchio¹, A. Lallo¹, F. Carrella¹, D. Barbarisi², A. Falzarano¹, M. De Falco³, F. Flora², A. Peluso², S. Piccolo², L. Flora² | ¹Department of Science and Technologies, University of Sannio, Italy; ²Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; ³Department of Biology, University of Naples, Italy

https://doi.org/10.4081/ejh.2025.4394

399

P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY T. Ishizuka, K. M. Aung, T. Kubota, B. Lkham-Erdene, K. Kai, Y. Hishikawa | Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

https://doi.org/10.4081/ejh.2025.4358

185

P04 | CYTOCHEMICAL AND BIOLOGICAL EFFECT OF BIORESONANCE IN IRRITABLE BOWEL SYNDROME G. Barassi¹, M. Panunzio², P.E. Gallenga¹ | ¹Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Responsible Research Hospital, Campobasso, Italy

https://doi.org/10.4081/ejh.2025.4324

254

THE USE OF BIOMIMETIC 2D AND 3D UROTHELIAL IN VITRO MODELS WITH MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF NORMAL AND CANCEROUS BLADDER TISSUE AS AN ALTERNATIVE METHOD IN PRECLINICAL STUDIES M.E. Kreft¹, L. Tratnjek¹, A. Janev¹, N. Resnik¹, U. Cerkvenik¹, U. D. Jerman¹, G. Markovič¹, T.Ž. Ramuta¹, T. Višnjar¹, Ž. Sardoč¹, A.Punčuh¹, S. Kralj², M. Čemažar³, P. Veranič¹ |¹Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; ²Department for Materials Synthesis, Jožef Stefan Institute, Ljubljana, Slovenia; ³Institute of Oncology Ljubljana, Ljubljana, Slovenia

https://doi.org/10.4081/ejh.2025.4288

236

P70 | TRICHOSANTHIN TARGETS WNT/NF-KB PATHWAYS TO ATTENUATE PSORIATIC INFLAMMATION AND KERATINOCYTE HYPERPROLIFERATION K. Wang¹, W. Li¹, Z. Ying¹, C. Li², O. Sha¹ | ¹Department of Anatomy and Histology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, China; ²Department of Anatomy, Shantou University Medical College, Shantou, China

https://doi.org/10.4081/ejh.2025.4395

329

P37 | THE ROLE OF ACTIN-BINDING PROTEINS IN ENDOMETRIOSIS W. Arendt¹, M. Hałas-Wiśniewska¹, M. Gagat², M. Izdebska¹ | ¹Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; ²Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

https://doi.org/10.4081/ejh.2025.4359

207

P05 | ENTERIC NERVOUS SYSTEM NEUROPLASTICITY IN COLON OF ANIMAL MODELS OF OBESITY V. Bellitto¹, I. Martinelli², G. Nittari², S.K. Tayebati², D. Tomassoni¹ | ¹School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; ²School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy

https://doi.org/10.4081/ejh.2025.4325

174

FROM BULK TO SELECTIVE: A JOURNEY THROUGH THE PHYSIOLOGICAL RELEVANCE OF AUTOPHAGY C. Settembre^1,2 | ¹ University of Naples Federico II, Naples, Italy; ²Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

https://doi.org/10.4081/ejh.2025.4290

177

P71 | THE EXTRACELLULAR VESICLE POPULATIONS UNDERWENT ALTERATIONS SUBSEQUENT TO THE PRETREATMENT OF ADIPOSE-DERIVED STEM CELLS WITH MELATONIN RECEPTOR AGONIST B. Sikora, K. Pogoda-Mieszczak, E. Bogunia, A. Skubis-Sikora, P. Czekaj | Department of Cytophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland

https://doi.org/10.4081/ejh.2025.4396

299

P38 | THE ROLE OF SPEXIN IN COLORECTAL CANCER J. Kiezun¹, J. Godlewski¹, M. Kiezun², M. Gudelska¹, K. Kisielewska¹, A. E. Kowalczyk¹, B. E. Krazinski¹ | ¹Department of Anatomy and Histology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland; ²Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Poland

https://doi.org/10.4081/ejh.2025.4360

212

P06 | MICROGRAVITY-INDUCED CHANGES IN CYTOSKELETON STRUCTURE OF TCAM-2 CELLS M. Berardini¹, L. Gesualdi¹, A. Di Pauli¹, M. Signore², S. Broccolucci¹, F. Ferranti³, M. Bizzarri⁴, M. Tafani⁴, G. Ricci⁵, A. Catizone¹ | ¹Dept of Anatomy, Histology, Forensic-Medicine and Orthopedics,“Sapienza” University of Rome, Rome, Italy; ²RPPA Unit, Proteomics Area, Core Facilities, Istituto Superiore di Sanità, Rome, Italy; ³Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; ⁴Dept of Experimental Medicine “Sapienza” University of Rome, Rome, Italy; ⁵Dept of Experimental Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy

https://doi.org/10.4081/ejh.2025.4326

203

ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy

https://doi.org/10.4081/ejh.2025.4291

259

P72 | A SWAB NEGATIVE PATIENT AFTER SARS-COV-2 INFECTION DISPLAYS INCREASE OF VEGF AND FIBRONECTIN ASSOCIATED WITH ALTERATIONS OF INTERCELLULAR JUNCTIONS C. Simioni¹, J.M. Sanz², R. Gafà³, G. Cenacchi⁴, S. Occhionorelli³, R. Rizzo⁵, D. Bortolotti⁵, A. Passaro³, L.M. Neri³ | ¹Department of Life Sciences and Biotechnology, University of Ferrara, Italy; ²Department of Chemical, Pharmaceutical and Agricultural, Sciences, University of Ferrara, Italy; ³Department of Translational Medicine, University of Ferrara, Italy; ⁴Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Italy; ⁵Department of Environmental and Prevention Sciences, University of Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4397

303

P40 | VOLUME ELECTRON MICROSCOPY REVEALS SPECIFIC FEATURES OF MITOTIC CELLS IN THE PINEAL ORGAN OF THE DOMESTIC TURKEY B. Lewczuk, N. Szyryńska, M. Prusik | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

https://doi.org/10.4081/ejh.2025.4362

182

P07 | DISRUPTED GUT-VASCULAR BARRIER AND INFLAMMATORY REMODELING IN MNGIE: A SPATIAL TRANSCRIPTOMIC AND HISTOLOGICAL STUDY S. Blando¹, E. Boschetti¹, I. Neri¹, L. Caporali², C. Fiorini², D. Ormanbekova², C. Malagelada³, I. Rusciano¹, V. Carelli², R. De Giorgio⁴, L. Manzoli¹, S. Ratti¹ | ¹Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum, University of Bologna, Italy; ²IRCCS Institute of Neurological Sciences of Bologna, Neurogenetics Program, Bologna, Italy; ³Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain; ⁴Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4327

177

THE EFFECT OF MUTANT HUNTINGTIN ON CLEAVAGE OF CREST BY CALPAIN-2 AND ITS CYTOTOXITY Y. Zhang, T. Peng, H. Li | Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China

https://doi.org/10.4081/ejh.2025.4292

188

P73 | ANALYSIS OF SAPK/JNK PATHWAY IN DOXORUBICIN INDUCED ADIPOSE-DERIVED STEM CELL CYTOTOXICITY A. Skubis-Sikora, B. Sikora, K. Pogoda-Mieszczak, E. Bogunia, P. Czekaj | Department of Cytophysiology, Chair of Histology and Embryology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland

https://doi.org/10.4081/ejh.2025.4398

295

P41 | INVOLVEMENT OF THE DOLPHIN’S MELON IN IMMUNE FUNCTION G.P. Lombardo¹, A. Miller², L. Spiccia¹, V. Natale¹, F. Pellicanò¹, G. Squadrito¹, E. R. Lauriano¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina; ²Department of Veterinary Sciences, University of Messina, Messina, Italy

https://doi.org/10.4081/ejh.2025.4363

220

P08 | COMBINED EFFECTS OF NONYLPHENOL AND STEROID HORMONES ON HUMAN PROSTATE CELL LINE S. Boccia¹, A. Mileo², F. Carrella³, R. Sciarrillo⁴, A. Capaldo¹, M. De Falco⁵ | ¹Dept. of Biology, University Federico II of Naples, Naples, Italy; ²Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; ³Dept. of Science and Technologies, University of Sannio, Benevento, Italy; ⁴Dept. of Science and Technologies, University of Sannio, Benevento, Italy; ⁵Dept. of Biology, University Federico II of Naples,; National Institute of Biostructures and Biosystems (INBB), Rome, Italy

https://doi.org/10.4081/ejh.2025.4328

194

HACAT CELLS AS A 2D EXPERIMENTAL DIFFERENTIATING MODEL TO ANALYZE THE EARLY BIOLOGICAL EFFECTS INDUCED BY A PSORIATIC PROINFLAMMATORY MICROENVIRONMENT: CELL PROLIFERATION, DIFFERENTIATION AND FERROPTOSIS F. Riva¹, S. Recalcati², E. Gammella², D. Daluiso¹, F. Prignano³, E. Donetti² | ¹Dept. Public Health, Experimental and Forensic Medicine; Histology and Embryology Unit, University of Pavia, Pavia, Italy; ²Dept. Biomedical Sciences for Health, University of Milan, Milan, Italy; ³Dept. Health Sciences, Section of Dermatology, University of Florence, Florence, Italy

https://doi.org/10.4081/ejh.2025.4293

200

P74 | EXPRESSION OF PISCIDIN, TLR-4, ERK2 AND P-P38 MAPK IN THE ZEBRAFISH GUT EXPOSED TO PCB-126 AND POSSIBLE PROTECTIVE EFFECTS OF GINESTEIN L. Spiccia¹, A. Miller², G.P. Lombardo¹, V. Natale¹, F. Pellicanò¹, S. Marino¹, A. Nunnari¹, A. Migliorato³, E.R. Laurian¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ²Department of Veterinary Sciences, University of Messina, Messina, Italy; ³Department of Biomedical and Dental Sciences and Morphofunctional Images, University of Messina, Messina, Italy

https://doi.org/10.4081/ejh.2025.4399

275

P42 | PANCREATIC CANCER STEM CELLS AND FUNCTIONAL CHARACTERIZATION OF MIR-216A-5P G. Fenu¹, C.G. Lison², F. Etzi³, A. Pisano³, C. Farace³, A. Sabalic³, D. Tutedde³, J.A. Marchal⁴, R. Madeddu⁵ | ¹Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy; ²Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ³Department of Biomedical Science, University of Sassari, Sassari, Italy; ⁴Instituto de Investigación Biosanitaria ibs. GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ⁵Department of Biomedical Science, University of Sassari, Sassari, Italy

https://doi.org/10.4081/ejh.2025.4364

190

P09 | EFFECTS OF NUTLIN-3A ACTIVITY ON 2D AND 3D RETINOBLASTOMA MODELS F. Bompan¹, R. Foschi², A. Dipinto³, F. Casciano², G. Lodi⁴, A. Sanvido⁵, P. Severi⁴, L. Giari¹, L. C. Cosenza⁵, R. Voltan², A. Romani⁴ | ¹Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; ²Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; LTTA Centre, University of Ferrara, Ferrara, Italy; ³Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; ⁴Department of Translational Medicine, University of Ferrara, Ferrara, Italy; LTTA Centre, University of Ferrara, Ferrara, Italy; ⁵Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4329

193

FROM CLOUD TO BEDSIDE C. Tacchetti^1,2| ¹Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; ²Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

https://doi.org/10.4081/ejh.2025.4294

213

P75 | MICROBIOTA-GUT-BRAIN AXIS IN AN AUTISM SPECTRUM DISORDER ANIMAL MODEL F. Sulas¹, G. Cominelli¹, G. Favero^1,2, D. Pinto^2,3, F. Rinaldi^2,3, R. Rezzani^1,2,4 | ¹Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; ²Interdepartmental University Center of Research Adaption and Regeneration of Tissues and Organs (ARTO), University of Brescia, Brescia, Italy; ³Human Microbiome Advanced Project Institute, Milan, Italy; ⁴Italian Society for the Study of Orofacial Pain (Società Italiana Studio Dolore Orofacciale - SISDO), Brescia, Italy

https://doi.org/10.4081/ejh.2025.4400

332

P43 | NEW INSIGHTS IN THE ACTIVATION OF FERROPTOSIS PROCESS DURING LIVER FIBROSIS R. Mancinelli¹, S. Leone¹, A. Casini¹, R. Vaccaro¹, M. Tagliafierro¹, F.M. Bassi¹, E. Bocci¹, S. Vitale¹, A. Franchitto², L. Pannarale¹, P. Onori¹, E. Gaudio¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; ²Division of Health Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Italy

https://doi.org/10.4081/ejh.2025.4365

240

P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy

https://doi.org/10.4081/ejh.2025.4330

180

USE OF HIGH-DEFINITION IMAGING FLOW CYTOMETRY AND A.I. TO ENUMERATE AND CHARACTERISE CIRCULATING TUMOUR CELLS S. Saravi¹, S. Panfilov², E. Karteris² | ¹College of Health, Medicine and Life Sciences, Brunel University of London, UK; ²College of Health, Medicine and Life Sciences, Brunel University of London, UK

https://doi.org/10.4081/ejh.2025.4295

184

P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

https://doi.org/10.4081/ejh.2025.4402

348

P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti^1,2, F. Beretti², M. Malenchini², M. Y. Follo¹, F. Mancarella³, F. Bonafè³, F. Gherardini⁴, T. Maraldi² | ¹Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; ²Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ³Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; ⁴Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy

https://doi.org/10.4081/ejh.2025.4366

179

P11 | DOMINO TRANSPLANTATION IN MNGIE: IS THE LIVER A SUITABLE GRAFT? E. Boschetti¹, I. Neri¹, S. Blando¹, C. Malagelada², L. Caporali³, R. D’Angelo⁴, R. Rinaldi⁴, S. Mongiorgi¹, V. Carelli³, R. De Giorgio⁵, L. Manzoli¹, S. Ratti¹ | ¹Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum – University of Bologna, Italy; ²Digestive System Research Unit, University Hospital Vall d’Hebron; Barcelona, Spain; ³IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; ⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁵Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4331

216

SUMOYLATION AS AN EARLY ADAPTIVE MECHANISM IN THE PROTEOMIC RESPONSE OF HUMAN GERM CELLS TO SIMULATED MICROGRAVITY A. Di Pauli¹, G. Ricci², M. Crescenzi³, M. A. Mariggiò⁴, C. Morabito⁴, L. Gesualdi¹, M. Berardini¹, F. Ferranti⁵, M. Signore⁶, A. Catizone¹ | ¹Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, Section of Histology and Embryology, «Sapienza» University, Rome, Italy; ²Department of Experimental Medicine, University «Luigi Vanvitelli», Naples, Italy; ³Core Facilities, Italian National Institute of Health, Rome, Italy; ⁴Department of Neuroscience, Imaging and Clinical Sciences CAST, «G. d’Annunzio» University, Chieti, Italy; ⁵Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; ⁶RPPA unit, Proteomics, Italian National Institute of Health, Rome, Italy

https://doi.org/10.4081/ejh.2025.4296

210

P77 | MEMBRANE SKELETAL PROTEIN, MEMBRANE PALMITOYLATED PROTEIN 6 (MPP6), IN MOUSE CEREBRAL SYNAPSES N. Terada¹, Y. Saitoh², S. Motofuji³, A. Kamijo⁴, T. Suzuki⁵, T. Yoshizawa⁶, T. Sakamoto⁷, K. Kametani⁸ | ¹Health Science Division, Shinshu University Graduate School of Medicine, Science and Technology, Japan; ²Center for Medical Education, Teikyo University of Science, Japan; ³Division of Biosciences, Teikyo University of Science Graduate School of Science & Engineering, Japan; ⁴Division of Basic & Clinical Medicine, Nagano College of Nursing, Japan; ⁵Department of Molecular and Cellular Physiology, Shinshu University Academic Assembly Institute of Medicine, Japan; ⁶Division of Animal Research, Research Center for Advanced Science and Technology, Shinshu University, Japan; ⁷Department of Cancer Biology, Institute of Biomedical Science, Kansai Medical University, Japan; ⁸Health Science Division, Shinshu University Graduate School of Medicine, Science and Technology, Japan

https://doi.org/10.4081/ejh.2025.4403

217

P45 | TARGETING PRELAMIN A PROCESSING TO SENSITIZE GLIOBLASTOMA CELLS TO OXIDATIVE STRESS M.V. Marvi¹, C. Evangelisti¹, I. Rusciano¹, I. Neri¹, L.I. Cocco¹, L. Manzoli¹, C. Capanni², S. Ratti¹ | ¹Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy; ²CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza», Unit of Bologna, Bologna, Italy / IRCCS Rizzoli Orthopedi, Institute, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4367

201

P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy

https://doi.org/10.4081/ejh.2025.4332

207

FROM PIXELS TO DIAGNOSIS: A DEEP LEARNING FRAMEWORK FOR HISTOPATHOLOGICAL IMAGE ANALYSIS IN CANINE TESTICULAR PATHOLOGY L. Riccio¹, E. Formisano², M. De Falco³, S. Balsamo³, P. Formisano⁴, E. Di Napoli¹, G. Piegari¹, O. Paciello¹, L. Rosati³ | ¹Department of Veterinary Medicine and Animal Production, University of Naples “Federico II”, Naples, Italy; ²Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Postbus 616, The Netherlands; ³Department of Biology, University of Naples Federico II, Naples, Italy; ⁴Department of Translational Medicine, University Federico II, Naples, Italy

https://doi.org/10.4081/ejh.2025.4297

193

P78 | THE ROLE OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STROMAL CELLS IN MYOFIBER REGENERATION A. Longhin¹, V. Gatta², G. Teti², C. Sassoli³, F. Chellini³, A. Tani³, M. Parigi³, R. Garella³, F. Palmieri³, R. Squecco³, M. Mattioli Belmonte⁴, C. Licini⁴, A. La Contana⁴, S. Zecchi Orlandini³, M. Falconi¹ | ¹Dep. Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ²Dep. Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; ³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; ⁴Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy

https://doi.org/10.4081/ejh.2025.4404

261

P46 | ANALYSIS OF AQUAPORIN-2 MUTANT MICE T. Matsuzaki¹, H. Yamamoto¹, K. Sasaki², H. Kogo¹, A. Iizuka-Kogo¹, M. Ikezawa¹, Y. Tajika¹ | ¹Dept. of Anatomy and Cell Biology, Graduate School of Medicine, Gunma University, Maebashi, Japan; ²Bioresource Center, Graduate School of Medicine, Gunma University, Maebashi; Faculty of Bioresources and Environmental Science, Ishikawa Prefectural University, Nonoichi, Japan

https://doi.org/10.4081/ejh.2025.4368

293

P13 | MORPHO-FUNCTIONAL DIFFERENCES IN THE GUT OF AGED MICE WITH THE POSSIBLE EFFECTS OF ANTI-INFLAMMATORY TREATMENTS A. Casini¹, S. Leone¹, R. Mancinelli¹, R. Vaccaro¹, M. Catalano², G. D’Alessandro², A. Rinaldi², A. Reccagni², G. Vivacqua³, A. Franchitto⁴, P. Onori¹, C. Limatola², E. Gaudio¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; ²Department of Physiology and Pharmacology, Sapienza University of Rome, Italy; ³Department of Medicine and Surgery, University Campus BioMedico of Rome, Italy; ⁴Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome «Foro Italico», Rome,Italy

https://doi.org/10.4081/ejh.2025.4333

175

THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland

https://doi.org/10.4081/ejh.2025.4298

173

P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE V. Bellitto¹, F. Grasselli¹, L. Lucernoni¹, I. Martinelli², E. Vittadini¹, A.M. Eleuteri¹, L. Bonfili¹, S.K. Tayebati², D. Tomassoni¹ | ¹School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; ²School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy

https://doi.org/10.4081/ejh.2025.4405

291

P47 | ASSESSMENT OF THE ANTI-INFLAMMATORY AND ANTIFIBROTIC EFFECTS OF HUMAN AMNIOTIC EPITHELIAL CELLS AFTER THEIR INTRATRACHEAL ADMINISTRATION IN A MOUSE MODEL OF BLEOMYCIN-INDUCED PULMONARY FIBROSIS E. Kolanko, A. Mazurski, A. Prusek, E. Bogunia, M. Hermyt, P. Czekaj | Department of Cytophysiology, Medical University of Silesia, Katowice, Poland

https://doi.org/10.4081/ejh.2025.4369

309

P14 | THE ROLE OF CHROMATIN REORGANIZATION IN HYPOXIA ADAPTATION M. Cavallo¹, C. Casali¹, L. Giulini¹, A. Dia¹, D. Tunesi¹, G. Milanesi¹, G. Mazzini², M. Biggiogera¹ | ¹Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia; Italy; ²Institute of Molecular Genetics, National Research Council (IGMCNR), Pavia, Italy

https://doi.org/10.4081/ejh.2025.4334

200

DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy

https://doi.org/10.4081/ejh.2025.4299

183

P80 | MITOCHONDRIA-LYSOSOME INTERACTIONS: EMERGING PLAYERS IN GLIOMA L. Zeppa¹, M.B. Morelli², C. Aguzzi², M. Giangrossi², M. Nabissi², G. Cameli², G. Santoni², S.K. Tayebati², V. Bellitto¹, D. Tomassoni¹, C. Amantini¹ | ¹School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; ²School of Pharmacy, University of Camerino, Camerino, Italy

https://doi.org/10.4081/ejh.2025.4406

332

P48 | NEW STRATEGIES TO IMPROVE THE RESPONSE OF AML CELLS TO TARGETED THERAPIES BY OVERCOMING THE PROTECTIVE EFFECT OF THE BONE MARROW MESENCHYMAL STEM CELLS G. Mazzanti¹, F. Liccardo², L. Pace¹, M. Marcotulli³, L. Lafrate³, G. Cidonio³, T. Ottone⁴, S. Travaglini⁴, M.T. Voso⁴, V. Fulci⁵, M. Sampaolesi¹, F. Fazi¹, S. Masciarelli¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences and Medical Embryology, Section of Histology Sapienza University of Rome, Rome, Italy; ²Centre de Recherches en Cancérologie de Toulouse, Inserm/ U1037, Université de Toulouse, Toulouse, France; ³Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy; ⁴Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; ⁵Department of Molecular Medicine, Sapienza, University of Rome, Rome, Italy

https://doi.org/10.4081/ejh.2025.4370

283

P15 | PHB/JAK/H3Y41PH AXIS REGULATES MEIOTIC RECOMBINATION IN SPERMATOGENESIS H. Chen¹, L. Zhang¹, W. Tan-Tai¹, M. Liu², H. Shi³, W. O⁴, P.A. Martin-DeLeon⁵ | ¹Department of Anatomy, Histology & Embryology, Shanghai Medical College, Fudan University, Shanghai, China; ²State Key Laboratory of Molecular Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China; ³NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China; ⁴School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China; ⁵Department of Biological Sciences, University of Delaware, Newark, USA

https://doi.org/10.4081/ejh.2025.4335

189

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.

https://doi.org/10.4081/ejh.2025.4300

188

LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou^1-6, M. Najajreh^1-4, D.P. Cook⁷, C.H. Maurer^1,2, S. Bärthel⁸, P. Putze⁸, H.A. Messal⁹, S.K. Ravichandran^1-3, T. Richter¹⁰, M. Knolle¹¹, T. Metzler¹², A.R. Shastri^1,2,3, R. Öllinger¹³, J. Jasper^1,2,3, L. Schmidleitner^1,2,3, C.Schneeweis⁸, H. Ishikawa-Ankerhold¹⁴, T. Engleitner¹³, S. Dobiasch¹⁵, I. Heid, M.D. Luecken¹⁶, K. Steiger¹², G. Kaissis¹¹, J. Van Rheenen⁹, F.J. Theis¹⁰, D. Saur⁸, R. Rad¹³, M. Reichert^{1,2,3,4,5,17,18} | ¹Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ²Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ³Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; ⁴Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; ⁵Bavarian Cancer Research Center (BZKF), Munich, Germany; ⁶Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; ⁷University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; ⁸Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; ⁹Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. ¹⁰Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; ¹¹Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; ¹²Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; ¹³Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; ¹⁴Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; ¹⁵Department of Radiation Oncology, Technical University of Munich, Germany; ¹⁶Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); ¹⁷German Cancer Consortium (DKTK), Munich, Germany; ¹⁸Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany

https://doi.org/10.4081/ejh.2025.4289

305

P81 | AN IN VITRO CYTOTOXIC, PROAPOPTOTIC AND ANTITUMOR ACTIVITY ASSESSMENT FOR CERAMIDASE INHIBITORS ON HUMAN LARYNGEAL CANCER CELLS C. Vejselova Sezer¹, M. Cengiz², B. Gür³, R. Dündar⁴, C. Cingi⁵, H.M. Kutlu⁶ | ¹Department of Biology, Kutahya Dumlupinar University, Kutahya, Türkiye; ²Department of Mathematics and Physical Sciences Education, Siirt University, Siirt, Türkiye; ³Department of Biochemistry, Iğdır University, Iğdır, Türkiye; ⁴Department of Otorhinolaryngology, Acibadem Eskişehir Hospital, Eskişehir, Türkiye; ⁵Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskişehir, Türkiye; ⁶Department of Biology, Eskişehir Technical University, Eskişehir, Türkiye

https://doi.org/10.4081/ejh.2025.4407

282

P49 | DEVELOPMENT OF AN INJECTABLE AND SELFASSEMBLING SCAFFOLD FOR THE DIRECT DELIVERY OF CARDIAC EXTRACELLULAR MATRIX AND CARDIAC PROGENITOR CELLS A. Menini¹, V. Romano¹, A. M. Sacco¹, D. Nurzynska², G. Ricci³, C. Amarelli⁴, C. Castaldo¹, F. Di Meglio¹ | ¹Department of Public Health, University of Naples «Federico II», Naples, Italy; ²Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi; ³Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy; ⁴Department of Cardiac Surgery and Transplants, Monaldi Hospital, Naples, Italy

https://doi.org/10.4081/ejh.2025.4371

287

P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER P. Chiodelli¹, J. Romoli¹, P. Bonassi Signoroni², E. Vertua², C. Ferrari³, E. Giuzzi², A. Paini², E. Scalvini², A. Papait¹, F.R. Stefani², A. R. Silini², O. Parolini¹ | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; ³Research and Clinical Trials Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy

https://doi.org/10.4081/ejh.2025.4336

179

FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

https://doi.org/10.4081/ejh.2025.4301

211

P39 | NEW PERSPECTIVES FOR THE EXPLOITATION OF FEMALE REPRODUCTIVE POTENTIAL IN MAMMALS: GENERATION OF GRANULOSA-LIKE CELLS FROM HUMAN ADIPOSE MESENCHYMAL STEM CELLS Y. Lacapra¹, D. Farini¹, G. Salvatore¹, M.A. Ucci¹, F.G. Klinger², M. De Felici¹, A. Camaio¹ | ¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy: ²Saint Camillus International University of Health Sciences, Rome, Italy

https://doi.org/10.4081/ejh.2025.4361

184

P82 | PROINFLAMMATORY BONE MARROW NICHES AND NEUTROPHIL ACTIVATION ARE ASSOCIATED WITH TIGIT EXPRESSION IN MULTIPLE MYELOMA V. Velardi¹, F. Arciprete¹, V. Tomarchio², G. Vivacqua¹, M.A. Tafuri², M. Di Cecca², L. Rigacci², A. Crescenzi³, R. Rana^1,O. Annibali², M. Zingariello¹ | ¹Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; ²Unit of Hematology, Stem Cell Transplantation, University Hospital Campus Bio-Medico Rome, Italy; ³Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy

https://doi.org/10.4081/ejh.2025.4408

288

P50 | OPTIMIZATION OF A RAPID AND EFFICIENT DECELLULARIZATION PROTOCOL FOR COMPOSITE VASCULARIZED FACIAL GRAFT FABRICATION A. Menini¹, A. M. Sacco¹, V. Romano¹, D. Nurzynska², G. Ricci³, S. La Padula¹, F. Schonauer¹, C. Castaldo¹, F. Di Meglio¹ | ¹Department of Public Health, University of Naples «Federico II», Naples, Italy; ²Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; ³Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy

https://doi.org/10.4081/ejh.2025.4372

262

P17 | INTERMITTENT FASTING AND FUCOIDAN ADMINISTRATION AMELIORATE THE EFFECT OF TYPE 2 DIABETES ON ENTERIC NERVOUS SYSTEM IN RATS A.M. Cırık¹, B. Erdem¹, E. Akar ¹, E. Akkuş¹, Ö. İleri-Meşe², H. Maraş², Z.N. Özdemir-Kumral³, M. Yüksel⁴, Ö.T. Çilingir-Kaya² | ¹Marmara Uni School of Medicine, Istanbul, Türkiye; ²Department of Histology and Embryology, Marmara Uni School of Medicine, Türkiye; ³Department of Physiology, Marmara Uni Faculty of Medicine, Türkiye; ⁴Department of Medical Laboratory Techniques, Vocational School of Health Services, Marmara Uni, Türkiye

https://doi.org/10.4081/ejh.2025.4337

194

LABELING EXTRACELLULAR VESICLES FOR HIGHLY SENSITIVE FLOW CYTOMETRY ANALYSES P. Simeone^1,2, D. Brocco³, F. D’Ascanio^1,2,4, D. De Bellis^1,2, G. Colasante^1,2, A. Aquilini-Mummolo^1,2, T. Esmail^1,2, A. Younas², M. Filoso², C. Cichella², M. C. Cufaro⁵, A. Di Sebastiano⁵, D. Pieragostino⁶, S. Burattini⁷, M. Battistelli⁷, P. Del Boccio⁵, A. Fontana⁸, R. Di Pietro¹, P. Lanuti^1,2 | ¹Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; ²Flow Cytometry Core Facility, Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” of Chieti-Pescara, Italy; ³Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; ⁴Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy: ⁵Department of Science, University “G. d’Annunzio”, Chieti Pescara, Italy; ⁶Department of Innovative Technologies in Medicine and Dentistry, G. d’Annunzio University of Chieti-Pescara, Italy; ⁷Department of Biomolecular Sciences, University of Urbino, Urbino, Italy; ⁸Department of Pharmacy, University “G. d’Annunzio”, Chieti Pescara, Italy

https://doi.org/10.4081/ejh.2025.4302

207

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria

https://doi.org/10.4081/ejh.2025.4263

354

P83 | INFLAMMATORY PROFILE IN SKIN, LUNG, AND KIDNEY OF A HOCL-INDUCED MURINE MODEL OF SYSTEMIC SCLEROSIS: AN IMMUNOHISTOCHEMICAL STUDY G. Vermiglio¹, J. Freni¹, F. Nicita¹, A. Centofanti¹, D. Labellarte¹, E. Rizzuto¹, A. Favaloro¹, M. Runci Anastasi², G.P. Anastasi¹, G. Cutroneo¹ | ¹Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; ²Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy

https://doi.org/10.4081/ejh.2025.4409

304

P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY A. Mileo¹, S. Boccia², E. Del Genio¹, R. Pastore¹, M. De Falco³, I. Belviso⁴ | ¹Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; ²Dept. of Biology, University of Naples Federico II, Naples, Italy; ³Dept. of Biology, University of Naples Federico II, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; ⁴Dept. of Wellness, Nutrition and Sport, Telematic University Pegaso, Naples, Italy

https://doi.org/10.4081/ejh.2025.4373

282

P18 | NESTIN EXPRESSION IN THE MYOCARDIUM OF SPONTANEOUSLY HYPERTENSIVE RATS AND CONPLASTIC SHR-MTBN STRAIN, AND CO-EXPRESSION WITH CONNEXIN 43 D. Cizkova¹, J. M. Zurmanova², T. Artykov¹, F. Galatik², B. Elsnicova², J. Silhavy³, M. Pravenec³, J. Mokry¹ | ¹Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; ²Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; ³Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

https://doi.org/10.4081/ejh.2025.4338

207

FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

https://doi.org/10.4081/ejh.2025.4303

188

David Glick Award Lecture | SUPER RESOLUTION MICROSCOPY: NEW APPROACHES TO DISCOVER THE TOPOGRAPHICAL SECRETS OF GENE REGULATION C. Cremer^1,2,3 | ¹Institute of Molecular Biology (IMB), Mainz, Germany; ²Max Planck Institute for Polymer Research, and for Chemistry, Mainz, Germany; ³Interdisciplinary Center for Scientific Computing (IWR), and Kirchhoff Institute for Physics, University Heidelberg, Heidelberg, Germany

https://doi.org/10.4081/ejh.2025.4264

399

P84 | OMOMYC PEPTIDE LOCALIZES IN THE NUCLEUS AND DISPLAYS ANTIPROLIFERATIVE EFFECTS ON CELLULAR MODELS OF HUMAN OSTEOSARCOMA I. Versari¹, S. Salucci¹, A. Bavelloni², M. Traversari³, I. Faenza¹ | ¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; ²Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4410

276

P52 | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL EVALUATION OF THE ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF HEMP EXTRACTS ON THE LIVER OF RATS INVOLVED IN INFLAMMATION CAUSED BY LPS A. Miller¹, M. Kotanska², M. Bednarski², G.P. Lombardo³, V. Natale³, G. Pirracchio³, L. Spiccia³, S. Pergolizzi³, G. Rizzo⁴, E.R. Lauriano³ | ¹Department of Veterinary Sciences, University of Messina, Messina, Italy; ²Department of Pharmacological Screening, Jagiellonian University Medical College, Kraków, Poland: ³Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ⁴Department of Clinical and Experimental Medicine, University of Messina, Italy

https://doi.org/10.4081/ejh.2025.4374

303

P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

https://doi.org/10.4081/ejh.2025.4339

235

EXPRESSION OF PIEZO1 IN CLEAR CELL RENAL CELL CARCINOMA: INSIGHTS FROM BIOINFORMATIC AND IMMUNOHISTOCHEMICAL ANALYSES D. Jerka¹, P. Antosik², K. Bonowicz^1,3, D. Grzanka⁴, M. Gagat^1,3 | ¹Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland; ²Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland; ³Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland; ⁴Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

https://doi.org/10.4081/ejh.2025.4304

239

1-100 of 137 Next

17th International Conference of Histochemistry and Cytochemistry, 2025

All Items

THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy

P33 | IMPACT OF CYCLIN C EXPRESSION ON THE AGGRESSIVENESS OF A549 NON-SMALL CELL LUNG CANCER CELLS V. Havryliuk | Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland

ACCELERATING DISCOVERY TOGETHER: A COMMUNITY APPROACH TO ANTIBODY VALIDATION AND MULTIPLEXED IMAGING A. Radtke | Leica Microsystems

ANIMAL MODELS FOR LINEAGE TRACING IN (CELL) TRANSDIFFERENTIATION S. Cinti | Center for The Study of Obesity. Marche Polytechnic University, Ancona, Italy

ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS S. Alberti | University of Messina, Messina, Italy

P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY T. Ishizuka, K. M. Aung, T. Kubota, B. Lkham-Erdene, K. Kai, Y. Hishikawa | Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

FROM BULK TO SELECTIVE: A JOURNEY THROUGH THE PHYSIOLOGICAL RELEVANCE OF AUTOPHAGY C. Settembre^1,2 | ¹ University of Naples Federico II, Naples, Italy; ²Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy

P40 | VOLUME ELECTRON MICROSCOPY REVEALS SPECIFIC FEATURES OF MITOTIC CELLS IN THE PINEAL ORGAN OF THE DOMESTIC TURKEY B. Lewczuk, N. Szyryńska, M. Prusik | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

THE EFFECT OF MUTANT HUNTINGTIN ON CLEAVAGE OF CREST BY CALPAIN-2 AND ITS CYTOTOXITY Y. Zhang, T. Peng, H. Li | Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China

FROM CLOUD TO BEDSIDE C. Tacchetti^1,2| ¹Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; ²Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy

P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy

THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland

DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.

FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria

FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

authors

reviewers

Categories

If and WoS

indexing

Keywords

17th International Conference of Histochemistry and Cytochemistry, 2025

All Items

THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy

P33 | IMPACT OF CYCLIN C EXPRESSION ON THE AGGRESSIVENESS OF A549 NON-SMALL CELL LUNG CANCER CELLS V. Havryliuk | Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland

ACCELERATING DISCOVERY TOGETHER: A COMMUNITY APPROACH TO ANTIBODY VALIDATION AND MULTIPLEXED IMAGING A. Radtke | Leica Microsystems

ANIMAL MODELS FOR LINEAGE TRACING IN (CELL) TRANSDIFFERENTIATION S. Cinti | Center for The Study of Obesity. Marche Polytechnic University, Ancona, Italy

ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS S. Alberti | University of Messina, Messina, Italy

P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY T. Ishizuka, K. M. Aung, T. Kubota, B. Lkham-Erdene, K. Kai, Y. Hishikawa | Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

FROM BULK TO SELECTIVE: A JOURNEY THROUGH THE PHYSIOLOGICAL RELEVANCE OF AUTOPHAGY C. Settembre1,2 | 1 University of Naples Federico II, Naples, Italy; 2Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy

P40 | VOLUME ELECTRON MICROSCOPY REVEALS SPECIFIC FEATURES OF MITOTIC CELLS IN THE PINEAL ORGAN OF THE DOMESTIC TURKEY B. Lewczuk, N. Szyryńska, M. Prusik | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

THE EFFECT OF MUTANT HUNTINGTIN ON CLEAVAGE OF CREST BY CALPAIN-2 AND ITS CYTOTOXITY Y. Zhang, T. Peng, H. Li | Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China

FROM CLOUD TO BEDSIDE C. Tacchetti1,2 | 1Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; 2Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy

P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy

THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland

DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.

FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria

FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

authors

reviewers

Categories

If and WoS

indexing

Keywords

FROM BULK TO SELECTIVE: A JOURNEY THROUGH THE PHYSIOLOGICAL RELEVANCE OF AUTOPHAGY C. Settembre^1,2 | ¹ University of Naples Federico II, Naples, Italy; ²Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

FROM CLOUD TO BEDSIDE C. Tacchetti^1,2| ¹Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; ²Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy