17th International Conference of Histochemistry and Cytochemistry, 2025

All Items

P73 | ANALYSIS OF SAPK/JNK PATHWAY IN DOXORUBICIN INDUCED ADIPOSE-DERIVED STEM CELL CYTOTOXICITY A. Skubis-Sikora, B. Sikora, K. Pogoda-Mieszczak, E. Bogunia, P. Czekaj | Department of Cytophysiology, Chair of Histology and Embryology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland

https://doi.org/10.4081/ejh.2025.4398

185

P41 | INVOLVEMENT OF THE DOLPHIN’S MELON IN IMMUNE FUNCTION G.P. Lombardo¹, A. Miller², L. Spiccia¹, V. Natale¹, F. Pellicanò¹, G. Squadrito¹, E. R. Lauriano¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina; ²Department of Veterinary Sciences, University of Messina, Messina, Italy

https://doi.org/10.4081/ejh.2025.4363

130

P08 | COMBINED EFFECTS OF NONYLPHENOL AND STEROID HORMONES ON HUMAN PROSTATE CELL LINE S. Boccia¹, A. Mileo², F. Carrella³, R. Sciarrillo⁴, A. Capaldo¹, M. De Falco⁵ | ¹Dept. of Biology, University Federico II of Naples, Naples, Italy; ²Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; ³Dept. of Science and Technologies, University of Sannio, Benevento, Italy; ⁴Dept. of Science and Technologies, University of Sannio, Benevento, Italy; ⁵Dept. of Biology, University Federico II of Naples,; National Institute of Biostructures and Biosystems (INBB), Rome, Italy

https://doi.org/10.4081/ejh.2025.4328

123

HACAT CELLS AS A 2D EXPERIMENTAL DIFFERENTIATING MODEL TO ANALYZE THE EARLY BIOLOGICAL EFFECTS INDUCED BY A PSORIATIC PROINFLAMMATORY MICROENVIRONMENT: CELL PROLIFERATION, DIFFERENTIATION AND FERROPTOSIS F. Riva¹, S. Recalcati², E. Gammella², D. Daluiso¹, F. Prignano³, E. Donetti² | ¹Dept. Public Health, Experimental and Forensic Medicine; Histology and Embryology Unit, University of Pavia, Pavia, Italy; ²Dept. Biomedical Sciences for Health, University of Milan, Milan, Italy; ³Dept. Health Sciences, Section of Dermatology, University of Florence, Florence, Italy

https://doi.org/10.4081/ejh.2025.4293

128

P74 | EXPRESSION OF PISCIDIN, TLR-4, ERK2 AND P-P38 MAPK IN THE ZEBRAFISH GUT EXPOSED TO PCB-126 AND POSSIBLE PROTECTIVE EFFECTS OF GINESTEIN L. Spiccia¹, A. Miller², G.P. Lombardo¹, V. Natale¹, F. Pellicanò¹, S. Marino¹, A. Nunnari¹, A. Migliorato³, E.R. Laurian¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ²Department of Veterinary Sciences, University of Messina, Messina, Italy; ³Department of Biomedical and Dental Sciences and Morphofunctional Images, University of Messina, Messina, Italy

https://doi.org/10.4081/ejh.2025.4399

161

P42 | PANCREATIC CANCER STEM CELLS AND FUNCTIONAL CHARACTERIZATION OF MIR-216A-5P G. Fenu¹, C.G. Lison², F. Etzi³, A. Pisano³, C. Farace³, A. Sabalic³, D. Tutedde³, J.A. Marchal⁴, R. Madeddu⁵ | ¹Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy; ²Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ³Department of Biomedical Science, University of Sassari, Sassari, Italy; ⁴Instituto de Investigación Biosanitaria ibs. GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ⁵Department of Biomedical Science, University of Sassari, Sassari, Italy

https://doi.org/10.4081/ejh.2025.4364

128

P09 | EFFECTS OF NUTLIN-3A ACTIVITY ON 2D AND 3D RETINOBLASTOMA MODELS F. Bompan¹, R. Foschi², A. Dipinto³, F. Casciano², G. Lodi⁴, A. Sanvido⁵, P. Severi⁴, L. Giari¹, L. C. Cosenza⁵, R. Voltan², A. Romani⁴ | ¹Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; ²Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; LTTA Centre, University of Ferrara, Ferrara, Italy; ³Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; ⁴Department of Translational Medicine, University of Ferrara, Ferrara, Italy; LTTA Centre, University of Ferrara, Ferrara, Italy; ⁵Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4329

129

FROM CLOUD TO BEDSIDE C. Tacchetti^1,2| ¹Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; ²Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

https://doi.org/10.4081/ejh.2025.4294

123

P75 | MICROBIOTA-GUT-BRAIN AXIS IN AN AUTISM SPECTRUM DISORDER ANIMAL MODEL F. Sulas¹, G. Cominelli¹, G. Favero^1,2, D. Pinto^2,3, F. Rinaldi^2,3, R. Rezzani^1,2,4 | ¹Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; ²Interdepartmental University Center of Research Adaption and Regeneration of Tissues and Organs (ARTO), University of Brescia, Brescia, Italy; ³Human Microbiome Advanced Project Institute, Milan, Italy; ⁴Italian Society for the Study of Orofacial Pain (Società Italiana Studio Dolore Orofacciale - SISDO), Brescia, Italy

https://doi.org/10.4081/ejh.2025.4400

194

P43 | NEW INSIGHTS IN THE ACTIVATION OF FERROPTOSIS PROCESS DURING LIVER FIBROSIS R. Mancinelli¹, S. Leone¹, A. Casini¹, R. Vaccaro¹, M. Tagliafierro¹, F.M. Bassi¹, E. Bocci¹, S. Vitale¹, A. Franchitto², L. Pannarale¹, P. Onori¹, E. Gaudio¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; ²Division of Health Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Italy

https://doi.org/10.4081/ejh.2025.4365

141

P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy

https://doi.org/10.4081/ejh.2025.4330

119

USE OF HIGH-DEFINITION IMAGING FLOW CYTOMETRY AND A.I. TO ENUMERATE AND CHARACTERISE CIRCULATING TUMOUR CELLS S. Saravi¹, S. Panfilov², E. Karteris² | ¹College of Health, Medicine and Life Sciences, Brunel University of London, UK; ²College of Health, Medicine and Life Sciences, Brunel University of London, UK

https://doi.org/10.4081/ejh.2025.4295

124

P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

https://doi.org/10.4081/ejh.2025.4402

183

P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti^1,2, F. Beretti², M. Malenchini², M. Y. Follo¹, F. Mancarella³, F. Bonafè³, F. Gherardini⁴, T. Maraldi² | ¹Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; ²Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ³Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; ⁴Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy

https://doi.org/10.4081/ejh.2025.4366

119

P11 | DOMINO TRANSPLANTATION IN MNGIE: IS THE LIVER A SUITABLE GRAFT? E. Boschetti¹, I. Neri¹, S. Blando¹, C. Malagelada², L. Caporali³, R. D’Angelo⁴, R. Rinaldi⁴, S. Mongiorgi¹, V. Carelli³, R. De Giorgio⁵, L. Manzoli¹, S. Ratti¹ | ¹Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum – University of Bologna, Italy; ²Digestive System Research Unit, University Hospital Vall d’Hebron; Barcelona, Spain; ³IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; ⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁵Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4331

142

SUMOYLATION AS AN EARLY ADAPTIVE MECHANISM IN THE PROTEOMIC RESPONSE OF HUMAN GERM CELLS TO SIMULATED MICROGRAVITY A. Di Pauli¹, G. Ricci², M. Crescenzi³, M. A. Mariggiò⁴, C. Morabito⁴, L. Gesualdi¹, M. Berardini¹, F. Ferranti⁵, M. Signore⁶, A. Catizone¹ | ¹Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, Section of Histology and Embryology, «Sapienza» University, Rome, Italy; ²Department of Experimental Medicine, University «Luigi Vanvitelli», Naples, Italy; ³Core Facilities, Italian National Institute of Health, Rome, Italy; ⁴Department of Neuroscience, Imaging and Clinical Sciences CAST, «G. d’Annunzio» University, Chieti, Italy; ⁵Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; ⁶RPPA unit, Proteomics, Italian National Institute of Health, Rome, Italy

https://doi.org/10.4081/ejh.2025.4296

135

P77 | MEMBRANE SKELETAL PROTEIN, MEMBRANE PALMITOYLATED PROTEIN 6 (MPP6), IN MOUSE CEREBRAL SYNAPSES N. Terada¹, Y. Saitoh², S. Motofuji³, A. Kamijo⁴, T. Suzuki⁵, T. Yoshizawa⁶, T. Sakamoto⁷, K. Kametani⁸ | ¹Health Science Division, Shinshu University Graduate School of Medicine, Science and Technology, Japan; ²Center for Medical Education, Teikyo University of Science, Japan; ³Division of Biosciences, Teikyo University of Science Graduate School of Science & Engineering, Japan; ⁴Division of Basic & Clinical Medicine, Nagano College of Nursing, Japan; ⁵Department of Molecular and Cellular Physiology, Shinshu University Academic Assembly Institute of Medicine, Japan; ⁶Division of Animal Research, Research Center for Advanced Science and Technology, Shinshu University, Japan; ⁷Department of Cancer Biology, Institute of Biomedical Science, Kansai Medical University, Japan; ⁸Health Science Division, Shinshu University Graduate School of Medicine, Science and Technology, Japan

https://doi.org/10.4081/ejh.2025.4403

118

P45 | TARGETING PRELAMIN A PROCESSING TO SENSITIZE GLIOBLASTOMA CELLS TO OXIDATIVE STRESS M.V. Marvi¹, C. Evangelisti¹, I. Rusciano¹, I. Neri¹, L.I. Cocco¹, L. Manzoli¹, C. Capanni², S. Ratti¹ | ¹Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy; ²CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza», Unit of Bologna, Bologna, Italy / IRCCS Rizzoli Orthopedi, Institute, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4367

149

P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy

https://doi.org/10.4081/ejh.2025.4332

131

FROM PIXELS TO DIAGNOSIS: A DEEP LEARNING FRAMEWORK FOR HISTOPATHOLOGICAL IMAGE ANALYSIS IN CANINE TESTICULAR PATHOLOGY L. Riccio¹, E. Formisano², M. De Falco³, S. Balsamo³, P. Formisano⁴, E. Di Napoli¹, G. Piegari¹, O. Paciello¹, L. Rosati³ | ¹Department of Veterinary Medicine and Animal Production, University of Naples “Federico II”, Naples, Italy; ²Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Postbus 616, The Netherlands; ³Department of Biology, University of Naples Federico II, Naples, Italy; ⁴Department of Translational Medicine, University Federico II, Naples, Italy

https://doi.org/10.4081/ejh.2025.4297

118

P78 | THE ROLE OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STROMAL CELLS IN MYOFIBER REGENERATION A. Longhin¹, V. Gatta², G. Teti², C. Sassoli³, F. Chellini³, A. Tani³, M. Parigi³, R. Garella³, F. Palmieri³, R. Squecco³, M. Mattioli Belmonte⁴, C. Licini⁴, A. La Contana⁴, S. Zecchi Orlandini³, M. Falconi¹ | ¹Dep. Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ²Dep. Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; ³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; ⁴Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy

https://doi.org/10.4081/ejh.2025.4404

151

P46 | ANALYSIS OF AQUAPORIN-2 MUTANT MICE T. Matsuzaki¹, H. Yamamoto¹, K. Sasaki², H. Kogo¹, A. Iizuka-Kogo¹, M. Ikezawa¹, Y. Tajika¹ | ¹Dept. of Anatomy and Cell Biology, Graduate School of Medicine, Gunma University, Maebashi, Japan; ²Bioresource Center, Graduate School of Medicine, Gunma University, Maebashi; Faculty of Bioresources and Environmental Science, Ishikawa Prefectural University, Nonoichi, Japan

https://doi.org/10.4081/ejh.2025.4368

171

P13 | MORPHO-FUNCTIONAL DIFFERENCES IN THE GUT OF AGED MICE WITH THE POSSIBLE EFFECTS OF ANTI-INFLAMMATORY TREATMENTS A. Casini¹, S. Leone¹, R. Mancinelli¹, R. Vaccaro¹, M. Catalano², G. D’Alessandro², A. Rinaldi², A. Reccagni², G. Vivacqua³, A. Franchitto⁴, P. Onori¹, C. Limatola², E. Gaudio¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; ²Department of Physiology and Pharmacology, Sapienza University of Rome, Italy; ³Department of Medicine and Surgery, University Campus BioMedico of Rome, Italy; ⁴Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome «Foro Italico», Rome,Italy

https://doi.org/10.4081/ejh.2025.4333

111

THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland

https://doi.org/10.4081/ejh.2025.4298

117

P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE V. Bellitto¹, F. Grasselli¹, L. Lucernoni¹, I. Martinelli², E. Vittadini¹, A.M. Eleuteri¹, L. Bonfili¹, S.K. Tayebati², D. Tomassoni¹ | ¹School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; ²School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy

https://doi.org/10.4081/ejh.2025.4405

170

P47 | ASSESSMENT OF THE ANTI-INFLAMMATORY AND ANTIFIBROTIC EFFECTS OF HUMAN AMNIOTIC EPITHELIAL CELLS AFTER THEIR INTRATRACHEAL ADMINISTRATION IN A MOUSE MODEL OF BLEOMYCIN-INDUCED PULMONARY FIBROSIS E. Kolanko, A. Mazurski, A. Prusek, E. Bogunia, M. Hermyt, P. Czekaj | Department of Cytophysiology, Medical University of Silesia, Katowice, Poland

https://doi.org/10.4081/ejh.2025.4369

189

P14 | THE ROLE OF CHROMATIN REORGANIZATION IN HYPOXIA ADAPTATION M. Cavallo¹, C. Casali¹, L. Giulini¹, A. Dia¹, D. Tunesi¹, G. Milanesi¹, G. Mazzini², M. Biggiogera¹ | ¹Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia; Italy; ²Institute of Molecular Genetics, National Research Council (IGMCNR), Pavia, Italy

https://doi.org/10.4081/ejh.2025.4334

121

DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy

https://doi.org/10.4081/ejh.2025.4299

133

P80 | MITOCHONDRIA-LYSOSOME INTERACTIONS: EMERGING PLAYERS IN GLIOMA L. Zeppa¹, M.B. Morelli², C. Aguzzi², M. Giangrossi², M. Nabissi², G. Cameli², G. Santoni², S.K. Tayebati², V. Bellitto¹, D. Tomassoni¹, C. Amantini¹ | ¹School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; ²School of Pharmacy, University of Camerino, Camerino, Italy

https://doi.org/10.4081/ejh.2025.4406

187

P48 | NEW STRATEGIES TO IMPROVE THE RESPONSE OF AML CELLS TO TARGETED THERAPIES BY OVERCOMING THE PROTECTIVE EFFECT OF THE BONE MARROW MESENCHYMAL STEM CELLS G. Mazzanti¹, F. Liccardo², L. Pace¹, M. Marcotulli³, L. Lafrate³, G. Cidonio³, T. Ottone⁴, S. Travaglini⁴, M.T. Voso⁴, V. Fulci⁵, M. Sampaolesi¹, F. Fazi¹, S. Masciarelli¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences and Medical Embryology, Section of Histology Sapienza University of Rome, Rome, Italy; ²Centre de Recherches en Cancérologie de Toulouse, Inserm/ U1037, Université de Toulouse, Toulouse, France; ³Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy; ⁴Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; ⁵Department of Molecular Medicine, Sapienza, University of Rome, Rome, Italy

https://doi.org/10.4081/ejh.2025.4370

169

P15 | PHB/JAK/H3Y41PH AXIS REGULATES MEIOTIC RECOMBINATION IN SPERMATOGENESIS H. Chen¹, L. Zhang¹, W. Tan-Tai¹, M. Liu², H. Shi³, W. O⁴, P.A. Martin-DeLeon⁵ | ¹Department of Anatomy, Histology & Embryology, Shanghai Medical College, Fudan University, Shanghai, China; ²State Key Laboratory of Molecular Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China; ³NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China; ⁴School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China; ⁵Department of Biological Sciences, University of Delaware, Newark, USA

https://doi.org/10.4081/ejh.2025.4335

136

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.

https://doi.org/10.4081/ejh.2025.4300

125

LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou^1-6, M. Najajreh^1-4, D.P. Cook⁷, C.H. Maurer^1,2, S. Bärthel⁸, P. Putze⁸, H.A. Messal⁹, S.K. Ravichandran^1-3, T. Richter¹⁰, M. Knolle¹¹, T. Metzler¹², A.R. Shastri^1,2,3, R. Öllinger¹³, J. Jasper^1,2,3, L. Schmidleitner^1,2,3, C.Schneeweis⁸, H. Ishikawa-Ankerhold¹⁴, T. Engleitner¹³, S. Dobiasch¹⁵, I. Heid, M.D. Luecken¹⁶, K. Steiger¹², G. Kaissis¹¹, J. Van Rheenen⁹, F.J. Theis¹⁰, D. Saur⁸, R. Rad¹³, M. Reichert^{1,2,3,4,5,17,18} | ¹Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ²Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ³Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; ⁴Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; ⁵Bavarian Cancer Research Center (BZKF), Munich, Germany; ⁶Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; ⁷University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; ⁸Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; ⁹Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. ¹⁰Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; ¹¹Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; ¹²Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; ¹³Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; ¹⁴Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; ¹⁵Department of Radiation Oncology, Technical University of Munich, Germany; ¹⁶Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); ¹⁷German Cancer Consortium (DKTK), Munich, Germany; ¹⁸Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany

https://doi.org/10.4081/ejh.2025.4289

181

P81 | AN IN VITRO CYTOTOXIC, PROAPOPTOTIC AND ANTITUMOR ACTIVITY ASSESSMENT FOR CERAMIDASE INHIBITORS ON HUMAN LARYNGEAL CANCER CELLS C. Vejselova Sezer¹, M. Cengiz², B. Gür³, R. Dündar⁴, C. Cingi⁵, H.M. Kutlu⁶ | ¹Department of Biology, Kutahya Dumlupinar University, Kutahya, Türkiye; ²Department of Mathematics and Physical Sciences Education, Siirt University, Siirt, Türkiye; ³Department of Biochemistry, Iğdır University, Iğdır, Türkiye; ⁴Department of Otorhinolaryngology, Acibadem Eskişehir Hospital, Eskişehir, Türkiye; ⁵Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskişehir, Türkiye; ⁶Department of Biology, Eskişehir Technical University, Eskişehir, Türkiye

https://doi.org/10.4081/ejh.2025.4407

180

P49 | DEVELOPMENT OF AN INJECTABLE AND SELFASSEMBLING SCAFFOLD FOR THE DIRECT DELIVERY OF CARDIAC EXTRACELLULAR MATRIX AND CARDIAC PROGENITOR CELLS A. Menini¹, V. Romano¹, A. M. Sacco¹, D. Nurzynska², G. Ricci³, C. Amarelli⁴, C. Castaldo¹, F. Di Meglio¹ | ¹Department of Public Health, University of Naples «Federico II», Naples, Italy; ²Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi; ³Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy; ⁴Department of Cardiac Surgery and Transplants, Monaldi Hospital, Naples, Italy

https://doi.org/10.4081/ejh.2025.4371

180

P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER P. Chiodelli¹, J. Romoli¹, P. Bonassi Signoroni², E. Vertua², C. Ferrari³, E. Giuzzi², A. Paini², E. Scalvini², A. Papait¹, F.R. Stefani², A. R. Silini², O. Parolini¹ | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; ³Research and Clinical Trials Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy

https://doi.org/10.4081/ejh.2025.4336

124

FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

https://doi.org/10.4081/ejh.2025.4301

125

P39 | NEW PERSPECTIVES FOR THE EXPLOITATION OF FEMALE REPRODUCTIVE POTENTIAL IN MAMMALS: GENERATION OF GRANULOSA-LIKE CELLS FROM HUMAN ADIPOSE MESENCHYMAL STEM CELLS Y. Lacapra¹, D. Farini¹, G. Salvatore¹, M.A. Ucci¹, F.G. Klinger², M. De Felici¹, A. Camaio¹ | ¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy: ²Saint Camillus International University of Health Sciences, Rome, Italy

https://doi.org/10.4081/ejh.2025.4361

129

P82 | PROINFLAMMATORY BONE MARROW NICHES AND NEUTROPHIL ACTIVATION ARE ASSOCIATED WITH TIGIT EXPRESSION IN MULTIPLE MYELOMA V. Velardi¹, F. Arciprete¹, V. Tomarchio², G. Vivacqua¹, M.A. Tafuri², M. Di Cecca², L. Rigacci², A. Crescenzi³, R. Rana^1,O. Annibali², M. Zingariello¹ | ¹Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; ²Unit of Hematology, Stem Cell Transplantation, University Hospital Campus Bio-Medico Rome, Italy; ³Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy

https://doi.org/10.4081/ejh.2025.4408

174

P50 | OPTIMIZATION OF A RAPID AND EFFICIENT DECELLULARIZATION PROTOCOL FOR COMPOSITE VASCULARIZED FACIAL GRAFT FABRICATION A. Menini¹, A. M. Sacco¹, V. Romano¹, D. Nurzynska², G. Ricci³, S. La Padula¹, F. Schonauer¹, C. Castaldo¹, F. Di Meglio¹ | ¹Department of Public Health, University of Naples «Federico II», Naples, Italy; ²Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; ³Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy

https://doi.org/10.4081/ejh.2025.4372

166

P17 | INTERMITTENT FASTING AND FUCOIDAN ADMINISTRATION AMELIORATE THE EFFECT OF TYPE 2 DIABETES ON ENTERIC NERVOUS SYSTEM IN RATS A.M. Cırık¹, B. Erdem¹, E. Akar ¹, E. Akkuş¹, Ö. İleri-Meşe², H. Maraş², Z.N. Özdemir-Kumral³, M. Yüksel⁴, Ö.T. Çilingir-Kaya² | ¹Marmara Uni School of Medicine, Istanbul, Türkiye; ²Department of Histology and Embryology, Marmara Uni School of Medicine, Türkiye; ³Department of Physiology, Marmara Uni Faculty of Medicine, Türkiye; ⁴Department of Medical Laboratory Techniques, Vocational School of Health Services, Marmara Uni, Türkiye

https://doi.org/10.4081/ejh.2025.4337

121

LABELING EXTRACELLULAR VESICLES FOR HIGHLY SENSITIVE FLOW CYTOMETRY ANALYSES P. Simeone^1,2, D. Brocco³, F. D’Ascanio^1,2,4, D. De Bellis^1,2, G. Colasante^1,2, A. Aquilini-Mummolo^1,2, T. Esmail^1,2, A. Younas², M. Filoso², C. Cichella², M. C. Cufaro⁵, A. Di Sebastiano⁵, D. Pieragostino⁶, S. Burattini⁷, M. Battistelli⁷, P. Del Boccio⁵, A. Fontana⁸, R. Di Pietro¹, P. Lanuti^1,2 | ¹Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; ²Flow Cytometry Core Facility, Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” of Chieti-Pescara, Italy; ³Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; ⁴Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy: ⁵Department of Science, University “G. d’Annunzio”, Chieti Pescara, Italy; ⁶Department of Innovative Technologies in Medicine and Dentistry, G. d’Annunzio University of Chieti-Pescara, Italy; ⁷Department of Biomolecular Sciences, University of Urbino, Urbino, Italy; ⁸Department of Pharmacy, University “G. d’Annunzio”, Chieti Pescara, Italy

https://doi.org/10.4081/ejh.2025.4302

125

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria

https://doi.org/10.4081/ejh.2025.4263

203

P83 | INFLAMMATORY PROFILE IN SKIN, LUNG, AND KIDNEY OF A HOCL-INDUCED MURINE MODEL OF SYSTEMIC SCLEROSIS: AN IMMUNOHISTOCHEMICAL STUDY G. Vermiglio¹, J. Freni¹, F. Nicita¹, A. Centofanti¹, D. Labellarte¹, E. Rizzuto¹, A. Favaloro¹, M. Runci Anastasi², G.P. Anastasi¹, G. Cutroneo¹ | ¹Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; ²Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy

https://doi.org/10.4081/ejh.2025.4409

179

P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY A. Mileo¹, S. Boccia², E. Del Genio¹, R. Pastore¹, M. De Falco³, I. Belviso⁴ | ¹Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; ²Dept. of Biology, University of Naples Federico II, Naples, Italy; ³Dept. of Biology, University of Naples Federico II, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; ⁴Dept. of Wellness, Nutrition and Sport, Telematic University Pegaso, Naples, Italy

https://doi.org/10.4081/ejh.2025.4373

174

P18 | NESTIN EXPRESSION IN THE MYOCARDIUM OF SPONTANEOUSLY HYPERTENSIVE RATS AND CONPLASTIC SHR-MTBN STRAIN, AND CO-EXPRESSION WITH CONNEXIN 43 D. Cizkova¹, J. M. Zurmanova², T. Artykov¹, F. Galatik², B. Elsnicova², J. Silhavy³, M. Pravenec³, J. Mokry¹ | ¹Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; ²Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; ³Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

https://doi.org/10.4081/ejh.2025.4338

133

FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

https://doi.org/10.4081/ejh.2025.4303

121

David Glick Award Lecture | SUPER RESOLUTION MICROSCOPY: NEW APPROACHES TO DISCOVER THE TOPOGRAPHICAL SECRETS OF GENE REGULATION C. Cremer^1,2,3 | ¹Institute of Molecular Biology (IMB), Mainz, Germany; ²Max Planck Institute for Polymer Research, and for Chemistry, Mainz, Germany; ³Interdisciplinary Center for Scientific Computing (IWR), and Kirchhoff Institute for Physics, University Heidelberg, Heidelberg, Germany

https://doi.org/10.4081/ejh.2025.4264

184

P84 | OMOMYC PEPTIDE LOCALIZES IN THE NUCLEUS AND DISPLAYS ANTIPROLIFERATIVE EFFECTS ON CELLULAR MODELS OF HUMAN OSTEOSARCOMA I. Versari¹, S. Salucci¹, A. Bavelloni², M. Traversari³, I. Faenza¹ | ¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; ²Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4410

175

P52 | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL EVALUATION OF THE ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF HEMP EXTRACTS ON THE LIVER OF RATS INVOLVED IN INFLAMMATION CAUSED BY LPS A. Miller¹, M. Kotanska², M. Bednarski², G.P. Lombardo³, V. Natale³, G. Pirracchio³, L. Spiccia³, S. Pergolizzi³, G. Rizzo⁴, E.R. Lauriano³ | ¹Department of Veterinary Sciences, University of Messina, Messina, Italy; ²Department of Pharmacological Screening, Jagiellonian University Medical College, Kraków, Poland: ³Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ⁴Department of Clinical and Experimental Medicine, University of Messina, Italy

https://doi.org/10.4081/ejh.2025.4374

195

P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

https://doi.org/10.4081/ejh.2025.4339

120

EXPRESSION OF PIEZO1 IN CLEAR CELL RENAL CELL CARCINOMA: INSIGHTS FROM BIOINFORMATIC AND IMMUNOHISTOCHEMICAL ANALYSES D. Jerka¹, P. Antosik², K. Bonowicz^1,3, D. Grzanka⁴, M. Gagat^1,3 | ¹Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland; ²Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland; ³Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland; ⁴Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

https://doi.org/10.4081/ejh.2025.4304

132

Paul Nakane Prize Lecture | FROM NUCLEOLAR MORPHOLOGY TO MOLECULAR REGULATION OF GENE EXPRESSION BY PHASE SEPARATION P. Hozák | Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

https://doi.org/10.4081/ejh.2025.4265

197

P85 | ALTERATION OF SUBMUCOSAL AND MYENTERIC GANGLIA IN SEVERE GUT DYSMOTILITY: A QUANTITATIVE MORPHOMETRIC ANALYSIS H. Yaghi¹, E. Boschetti¹, S. Blando¹, I. Neri¹, C. Malagelada², R. De Giorgio³, L. Manzoli¹, S. Ratti¹ | ¹Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum, University of Bologna, Bologna, Italy; ²Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain; ³Department of Translational Medicine, Università di Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4411

160

P53 | CIRCADIAN DEPENDENT MOTILITY: THE ROLE FOR THE PERINUCLEAR ACTIN CAP E. Montacci¹, M. Sgarzi², L. Dall’Olio³, E. Giampieri⁴, D. Romaniello⁴, M. Lauriola⁵ | ¹Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ²IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ³Laboratory of Data Science and Bioinformatics, IRCSS Institute of Neurological Sciences, Bellaria Hospital, Bologna, Italy; ⁴Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ⁵Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4375

164

P20 | RNASEQ AND HISTOCHEMICAL STAININGS ASSESS BIOCHEMICAL AND STRUCTURAL CHANGES IN THE MOUSE INTERVERTEBRAL DISC ACROSS THE LIFESPAN A. Hallmark¹, A. Ali², C. Dahia³ | ¹Hospital for Special Surgery, New York, USA; ²Department of Medicine, Columbia University, New York, USA; ³Hospital for Special Surgery, Weill Cornell Medicine

https://doi.org/10.4081/ejh.2025.4340

128

TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti¹, M. C. Gagliani², G. Bellese², M. Crippa³, A. Abbona⁴, M. Paccagnella⁴, P. Arnaldi⁵, M. C. Merlano⁶, O. Garrone⁷, A.M. Porcelli⁸, M. Matteoli¹, P. Falletta⁹, P. Castagnola¹⁰, K. Cortese² | ¹IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; ²DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; ³Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; ⁴Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; ⁵IRCCS Ospedale Policlinico San Martino, Genova, Italy; ⁶Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; ⁷Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; ⁸FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; ⁹Vita-Salute San Raffaele University, Milan, Italy; ¹⁰IRCCS Ospedale Policlinico San Martino, Genova, Italy

https://doi.org/10.4081/ejh.2025.4305

186

IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini^1,2 | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

https://doi.org/10.4081/ejh.2025.4266

218

P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES I. Atasoy¹, S. Yilmazer², D. Gezen Ak³, E. Dursun³ | ¹Medical Biology Department, İstabul University-Cerrahpasa Faculty of Medicine Istanbul, Türkiye; ²Department of Medical Biology Halic University, Faculty of Medicine, Istanbul, Türkiye; ³Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Türkiye

https://doi.org/10.4081/ejh.2025.4412

178

PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS L. Morello¹, G. Stati¹, V. Giansante¹, S. Lattanzio¹, P. Cerritelli¹, D. Bruni¹, S. Cinti², R. Di Pietro^1,3,4 | ¹Department of Medicine and Aging Sciences, “G. d’ Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Experimental and Clinical Medicine, Center of Obesity, Polytechnic University of Marche, Ancona, Italy; ³StemTeCh Group, G. d’ Annunzio Foundation, “G. d’ Annunzio” University of Chieti Pescara, Chieti, Italy; ⁴Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA

https://doi.org/10.4081/ejh.2025.4379

178

P21 | EARLY BIOLOGICAL EFFECTS ON CELL PROLIFERATION AND DIFFERENTIATION INDUCED BY EXTRACELLULAR MICROVESICLES (EVS) DERIVED FROM HUMAN KERATINOCYTES IN PSORIATIC MICROENVIRONMENT D. Daluiso¹, B. Barco¹, C. Porro², E. Donetti³, F. Riva¹ | ¹Department of Publich Health, Experimental and Forensic Medicine, Histology and Embryology Unit, University of Pavia, Pavia, Italy; ²Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; ³Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

https://doi.org/10.4081/ejh.2025.4341

125

SPATIO-TEMPORAL ORGANIZATION OF THE SUPER-ENHANCER STRUCTURE IN CANCER CELLS A. Chytła¹, E. H. Lagunar¹, R. Gonül¹, B. Šalovská², J. Červenka³, A. Miladinović⁴, L. Antiga⁴, P. Hozák⁴, M. Sztacho¹ | ¹Laboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; ²Yale Cancer Biology Institute, Yale University School of Medicine, West Haven, USA; ³Laboratory of proteomics, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; ⁴Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

https://doi.org/10.4081/ejh.2025.4306

150

A TECHNOLOGY PLATFORM FOR TRANSLATION OF ATMPS (ADVANCED THERAPY MEDICINAL PRODUCTS): THE EXAMPLE OF HUMAN EYE AND SKIN G. Pellegrini | Head of Cell Therapy Program Center for Regenerative Medicine Department of Life Sciences University of Modena e Reggio Emilia, Modena, Italy

https://doi.org/10.4081/ejh.2025.4269

190

P87 | EVALUATION OF SPEXIN AND KISSPEPTIN EXPRESSIONS IN ADIPOSE TISSUES OF WISTAR ALBINO RATS DURING PUBERTY A.H. Yozgat¹, D. Billur¹, B.I Erguder², A. Ucar³ | ¹Ankara University Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye; ²Ankara University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye; ³University of Health Sciences, Sisli Hamidiye Etfal Health Practices and Research Centre, Department of Pediatric Endocrinology and Diabetes, Istanbul, Türkiye

https://doi.org/10.4081/ejh.2025.4413

171

P55 | ENDOTHELIAL THYMIDINE PHOSPHORYLASE DEFICIENCY TRIGGERS MORPHO-FUNCTIONAL DEGE-NERATION OF ENTERIC NEURONS AND REDUCES INTESTINAL STEM CELL PROLIFERATION I. Neri¹, E. Boschetti¹, T. Saha², S. Rommel², S. Schulte², M. Gries², R. De Giorgio³, L. Manzoli¹, S. Ratti¹, K. Schäfer² | ¹Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ²Workgroup Enteric Nervous System (AGENS), Department of Informatics and Microsystems Technology, University of Applied, Sciences Kaiserslautern, Zweibrücken, Germany; ³Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4380

169

P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira¹, S. Grassilli², M. Pierantoni¹, V. Bertagnolo¹, F. Brugnoli¹ | ¹Department of Translational Medicine, University of Ferrara, Ferrara, Italy; ²Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4342

144

ADVANCEMENTS AND EMERGING PERSPECTIVES IN MICROSCOPIC IMAGING S. Karahuseyinoglu | Department of Histology & Embryology, Koc University, School of Medicine, Istanbul, Turkiye

https://doi.org/10.4081/ejh.2025.4307

164

ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA

https://doi.org/10.4081/ejh.2025.4270

189

P88 | REGENERATIVE MEDICINE, REHABILITATION AND CYTO-HISTOCHEMISTRY: RECENT EVALUATIONS OF INTEGRATED TREATMENTS L. Gatta^1,2, M. Ceccarelli^1,3, C. Del Gaizo¹ | ¹BIORI, Academy of Bioregenerative Medicine and Surgery; Rome, Italy; ²Catholic University of Rome, Policlinico Gemelli, Rome, Italy; ³International Center for Study and Research in Physiological and Aesthetic Medicine (Ae. Phy. Med. Centre), Rome, Italy.

https://doi.org/10.4081/ejh.2025.4414

159

P56 | HISTOLOGICAL PROFILE OF INACTIVE UNILATERAL CONDYLAR HYPERPLASIA: EVIDENCE OF BORDERLINE TISSUE ACTIVITY F. Nicita¹, G. Vermiglio¹, J. Freni¹, A. Centofanti¹, D. Labellarte¹, R. Briganti¹, G.P. Anastasi¹, G. Cutroneo¹, A. Favaloro¹, M. Runci Anastasi² | ¹Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; ²Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy

https://doi.org/10.4081/ejh.2025.4381

175

P23 | CALRETININ IMMUNOREACTIVE NON-TRADITIONAL LARGE NEURONS IN THE GRANULAR LAYER OF THE HUMAN CEREBELLAR CORTEX P. Flace¹, M. E. Caringella², D. Galletta³, G. Santangelo³, C. Caporusso², M. Stolfa², A. Cacciola⁴, J.J.V. Branca⁵, G. Agazzino², R. Gradini⁶, P. Livrea⁷, A. Marzullo² | ¹Medical School, University of Bari ‘Aldo Moro’, Bari, Italy; ²Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, Italy; ³Department of Psychology, Specialization School of Neuropsychology. University of Campania ‘Luigi Vanvitelli’, Caserta, Italy; ⁴Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; ⁵Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy; ⁶Department of Experimental Medicine, Sapienza University, Roma, Italy; ⁷University of Bari ‘Aldo Moro’, Bari, Italy

https://doi.org/10.4081/ejh.2025.4343

121

IMAGING THE LYSOSOME IN CELLULAR SYSTEMS FOR DRUG DISCOVERY AND SCREENING V.A. Baldassarro¹, M. Galeotti², E. Satanassi³, L. Giardino¹, L. Calzà⁴, C. Quadalti⁴ | ¹DIMEVET, University of Bologna, Italy; ²IRET Foundation, Ozzano dell’Emilia, Bologna, Italy; ³Interdepartmental Centre for Industrial Research in Health Sciences and Technology ICIR-HST, University of Bologna, Ozzano dell’Emilia, Bologna, Italy; ⁴Fabit, University of Bologna, Italy

https://doi.org/10.4081/ejh.2025.4308

164

HUMAN AMNIOTIC MEMBRANE POTENTIAL FOR BONE REPAIR: FROM THE LAB TO THE CLINIC - ROLE OF ITS IMMUNOGENICITY F. Gindraux^1,2 | ¹CHU Besançon, Service de Chirurgie Maxillo-Faciale et Stomatologie, Besançon, France; ²Université Marie et Louis Pasteur, SINERGIES UR 4662, Besançon, France

https://doi.org/10.4081/ejh.2025.4271

123

P57 | SELONSERTIB (ASK1 INHIBITOR) IN SKIN TISSUE REPAIR OF OBESE MICE V. Oliveira Collares Barbos, B. Romana de Souza | Department of Histology and Embriology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

https://doi.org/10.4081/ejh.2025.4382

184

P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia¹, C. Girone¹, D.M. Filippini², G. Querzoli³, M. Fermi⁴, S. Venturoli⁵, A. Degiovanni⁶, C. Miroglio¹, E. Montacci¹, A. Ardizzoni⁷, M. Lauriola⁸, D. Romaniello⁸ | ¹Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ²Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁴Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁵Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; ⁶Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; ⁷Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁸Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4344

126

ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi¹, V. Righi², A. Mucci³, I. Rusciano¹, S. Mongiorgi¹, M. Shin⁴, Y. Kosodo⁴, I. Cani⁵, P. Cortelli⁶, E. Giorgio⁷, G. Ramazzotti¹, L. Manzoli¹, S. Ratti¹ | ¹ Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ²Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; ³Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; ⁴Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; ⁵Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ⁶IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; ⁷Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.

https://doi.org/10.4081/ejh.2025.4312

179

HUMAN AMNIOTIC EPITHELIAL CELLS FOR RETINAL REGENERATION: INVESTIGATING THEIR DIFFERENTIATIVE POTENTIAL IN VITRO R. Pisu¹, S. Saponara², S. Angioni², E. Peiretti², S.G. Vitale², F. Marongiu¹ | ¹Department of Biomedical Sciences, University of Cagliari, Cagliari; ²Department of Surgical Sciences, University of Cagliari, Cagliari, Italy

https://doi.org/10.4081/ejh.2025.4272

126

P58 | VITAMIN D ATTENUATES LIVER INJURY BY REDUCING APOTOSIS, PYROPTOSIS, FERROPTOSIS AND PROMOTING REGENERATION IN TYPE 2 DIABETES S. Rzeyeva¹, N. Bayromava², T. Ozbilenler¹, A. Akdemir³, M. Anapalı Aykaç⁴, D. Aydemir⁵, F. Kaya Dagistanli¹, T. Ulutin¹, O. Uysal¹, M. Ozturk⁶ | ¹Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye; ²Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye; ³Karabuk University, Faculty of Medicine, Karabük, Türkiye; ⁴Ataturk University, Faculty of Medicine, Erzurum, Türkiye; ⁵Istanbul University, Faculty of Medicine, Istanbul, Türkiye; ⁶Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul Türkiye

https://doi.org/10.4081/ejh.2025.4383

173

P25 | RESPONSE TO HEDGEHOG AND PI3K/AKT/MTOR PATHWAY INHIBITORS IN PREB-ALL: ANALYSIS OF THE INTRACELLULAR DISTRIBUTION OF PATHWAY ENZYMES AND OF THE AUTOPHAGY PROCESS M. Sicurella¹, M. De Chiara², E. Battaglia², F. Franco², M. De Vita², L.M. Neri² | ¹Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; ²Department of Translational Medicine, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4345

133

THE FACETED S100B PROTEIN: THE JEKYLL/HYDE SIDE F. Michetti | LUM University Casamassima, Genes Company, Roma, Italy

https://doi.org/10.4081/ejh.2025.4313

173

PERICYTE INVOLVEMENT IN THE PATHOGENESIS OF COLVI-RELATED MYOPATHIES: INSIGHTS INTO NG2–COLVI AXIS A. Fazio¹, C. Evangelisti¹, P. Sabatelli², A. Cappellini¹, A. Di Martino³, C. Faldini³, L. Manzoli¹, S. Ratti¹ | ¹Cellular Signalling Laboratory, University of Bologna, DIBINEM, Bologna, Italy; ²CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza”, Unit of Bologna, Bologna, Italy; ³IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4273

108

P59 | IMMUNOHISTOCHEMISTRY ANALYSIS TO DETECT A MOLECULAR SIGNATURE IN INTERVERTEBRAL DISC DEGENERATION L. Penolazzi¹, R. Nadalini¹, C. Sief¹, E. Lambertini², C. Angelini³, R. Piva¹ | ¹Department of Neurosciences and rehabilitation, University of Ferrara, Italy; ²Laboratorio Centralizzato di ricerca preclinica, University of Ferrara, Italy; ³Department of Translational Medicine, University of Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4384

177

P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION J. Freni¹, M. Crescenti², E. Bertuccio³, A. Fittipaldi¹, P. Carrega², E. Di Carlo⁴, G. Ferlazzo³, G. Vermiglio¹, I. Bonaccorsi² | ¹Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy: ²Department Human Pathology, «G. Barresi», University of Messina, Messina, Italy; ³Department of Experimental Medicine (DIMES), University of Genoa, Genova, Italy; ⁴Department of Medicine and Sciences of Aging, «G. D’Annunzio» University of Chieti-Pescara, Chieti, Italy

https://doi.org/10.4081/ejh.2025.4346

141

HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES G. Di Sante¹, A. M. Stabile¹, A. Pistilli¹, M. Ruggirello^1,2, F. Michetti^3,4, F. Ria², M. Rende¹ | ¹ Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; ²Department of Translational Medicine and Surgery, Section of General Pathology, University “Cattolica del Sacro Cuore” of Rome, Roma, Italy; ³Department of Medicine, LUM University, Casamassima, Bari, Italy; ⁴Italy Genes, Rome, Italy

https://doi.org/10.4081/ejh.2025.4314

172

THE AUTOPHAGY-INDEPENDENT ROLE OF ATG7 IN REGULATING NEUROGENESIS Y. Shen, G. Wang | International Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou, China

https://doi.org/10.4081/ejh.2025.4274

128

P60 | UNDERSTANDING HUMAN INTERVERTEBRAL DISC HOMEOSTASIS: 3D EXPERIMENTAL MODELS L. Penolazzi¹, A. Chierici¹, R. Nadalini¹, E. Lambertini², C. Nastruzzi³, G. Lisignoli⁴, C. Manferdini⁴, G. D’Atri⁴, R. Piva¹ | ¹Department of Neurosciences and rehabilitation, University of Ferrara, Italy; ²Laboratorio centralizzato di ricerca preclinica, University of Ferrara, Italy; ³Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Italy; ⁴Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

https://doi.org/10.4081/ejh.2025.4385

173

P27 | HISTOCHEMICAL APPROACHES FOR EVALUATING THE REPRODUCTIVE HEALTH OF MUSSEL MYTILUS GALLOPROVINCIALIS EXPOSED TO ACUTE THERMAL STRESS M. Galati, M. A. Oueldi, M. Romeo, T. Cappello, M. Maisan | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy

https://doi.org/10.4081/ejh.2025.4347

129

ON THE WAY TO A NEW MODEL OF NEURODEGENERATION? FIRST EVIDENCE OF THE EXPRESSION OF GATA1 IN THE BRAIN: CORRELATIONS WITH AGING, MITOCHONDRIAL DAMAGE AND SYNUCLEINOPATHY C. Caturano¹, F. E. Bellomi¹, F. Arciprete¹, V. Velardi¹, L. La Barbera², M. Falchi³, M. Bacioglu⁴, R. Mancinelli⁵, M. D’Amelio², M. Spillantini⁴, M. Zingariello¹, G. Vivacqua^1,6 | ¹Laboratory of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Rome, Italy; ²Laboratory of Molecular Neuroscience - Campus Biomedico University of Rome, Italy; ³National Centre for HIV/AIDS Research, Istituto Superior di Sanità, Rome, Italy; ⁴Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK; ⁵Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy; ⁶Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK

https://doi.org/10.4081/ejh.2025.4315

173

UNRAVELING THE RELATIONSHIPS BETWEEN TUMOR CELLS AND THEIR MICROENVIRONMENT USING HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS M. Cordenonsi |Department of Molecular Medicine, University of Padova, Padova, Italy

https://doi.org/10.4081/ejh.2025.4275

122

P61 | IMMUNOPROFILE OF MERKEL CELLS IN THE HUMAN VAGINAL EPITHELIUM S. Polakovičová¹, M. Borovský², L. Maršík², B. Filová³, I. Varga³, L. Sallicandro⁴ | ¹Inst. of Hist. and Embr. MFCU in Bratislava, Bratislava, Slovakia; ²1st Obst. and Gyn. Dep. FMCU with Repr. Med. Centre Hospital, Bratislava, Slovakia; ³Inst. of Hist. and Embr. MFCU in Bratislava, Bratislava, Slovakia; ⁴Dep. of Medicine and Surgery, University of Perugia, Perugia, Italy

https://doi.org/10.4081/ejh.2025.4386

158

P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante¹, L. Leanza², E. Guerra³, F. Vianello⁴, C. Iacovino¹, S. Lattanzio¹, L. Morello¹, G. Stati¹, P. Simeone³, P. Lanuti³, S. Alberti⁵, M. Reichert⁶, R. Di Pietro¹ | ¹Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Biology, University of Padua, Padua, Italy; ³Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; ⁴Department of Biology, University of Padua, Padua, Italy; ⁵Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; ⁶Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany

https://doi.org/10.4081/ejh.2025.4348

129

IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

https://doi.org/10.4081/ejh.2025.4316

176

ROLE OF SCHWANN CELLS-CANCER CELLS CROSSTALK IN TUMOUR PROGRESSION C. Giampietri¹, E. Pizzichini¹, F. Somma¹, S. Petrungaro¹, A. Facchiano², A. Filippini¹, C. Fabrizi¹, E. Gaudio¹ | ¹Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; ²Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy

https://doi.org/10.4081/ejh.2025.4276

137

P62 | FFAR4/GPR120 ACTIVATION COUNTERACTS FIBROGENIC PATHWAYS IN A CHOLESTATIC LIVER INJURY MODEL S. Pompili¹, R. Sferra¹, F. Ronca¹, A. Cappariello², A. Vetuschi¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; ²Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

https://doi.org/10.4081/ejh.2025.4387

178

P29 | GLUTAMATERGIC MODULATION OF HYPOTHALAMIC RSPONDIN3 NEURONS UNDER PHYSIOLOGICAL CONDITIONS D. Gok Yurtseven¹, G. Topal¹, N. Hasanoglu Akbulut², D. Udum³, M. Yalcın⁴, O. Eyigor¹ | ¹Department of Histology and Embryology, Bursa Uludag University, Faculty of Medicine, Bursa, Türkiye; ²Department of Histology and Embryology, Canakkale Onsekiz, Mart University, Faculty of Medicine, Canakkale, Türkiye; ³Department of Biochemistry, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Türkiye; ⁴Department of Veterinary Physiology, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Türkiye

https://doi.org/10.4081/ejh.2025.4349

129

THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

https://doi.org/10.4081/ejh.2025.4317

162

CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti¹, V. Serafin¹, L. Antolini¹, S. Bresolin², L. Reggiani Bonetti³, S. Marmiroli¹ | ¹Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; ²Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; ³Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy

https://doi.org/10.4081/ejh.2025.4277

129

P63 | ROLE OF ION CYCLOTRON RESONANCE ON BODY ELECTRICAL IMPEDANCE IN CHRONIC PAIN: CLINICAL EFFECTS AND FUTURE PERSPECTIVES L. Prosperi¹, G. Barassi1, M. Panunzio², P. Spaggiari³, P.E. Gallenga¹ | ¹Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Responsible Research Hospital, Campobasso, Italy; ³Scientific Association of Integrated Biochemical and Biophysical Medicine (A.M.B.B.), Mantova, Italy

https://doi.org/10.4081/ejh.2025.4388

194

P30 | NEW INSIGHT IN THE IN VITRO-GENERATION OF INSULIN-PRODUCING CELLS: VAV1 AS A REGULATOR OF PDX1 AND MIR-375 LEVELS DURING DIFFERENTIATION OF HIPSCS INTO Β-CELLS M. Pierantoni¹, F. Brugnoli¹, V. Zamarian², M. Dell’Aira¹, V. Sordi², V. Bertagnolo¹, S. Grassilli³ | ¹Department of Translational Medicine, University of Ferrara, Ferrara, Italy; ²Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; ³Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy

https://doi.org/10.4081/ejh.2025.4350

123

NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

https://doi.org/10.4081/ejh.2025.4318

179

1-100 of 137 Next

17th International Conference of Histochemistry and Cytochemistry, 2025

All Items

FROM CLOUD TO BEDSIDE C. Tacchetti^1,2| ¹Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; ²Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy

P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy

THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland

DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.

FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria

FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

Paul Nakane Prize Lecture | FROM NUCLEOLAR MORPHOLOGY TO MOLECULAR REGULATION OF GENE EXPRESSION BY PHASE SEPARATION P. Hozák | Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini^1,2 | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

A TECHNOLOGY PLATFORM FOR TRANSLATION OF ATMPS (ADVANCED THERAPY MEDICINAL PRODUCTS): THE EXAMPLE OF HUMAN EYE AND SKIN G. Pellegrini | Head of Cell Therapy Program Center for Regenerative Medicine Department of Life Sciences University of Modena e Reggio Emilia, Modena, Italy

ADVANCEMENTS AND EMERGING PERSPECTIVES IN MICROSCOPIC IMAGING S. Karahuseyinoglu | Department of Histology & Embryology, Koc University, School of Medicine, Istanbul, Turkiye

ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA

HUMAN AMNIOTIC MEMBRANE POTENTIAL FOR BONE REPAIR: FROM THE LAB TO THE CLINIC - ROLE OF ITS IMMUNOGENICITY F. Gindraux^1,2 | ¹CHU Besançon, Service de Chirurgie Maxillo-Faciale et Stomatologie, Besançon, France; ²Université Marie et Louis Pasteur, SINERGIES UR 4662, Besançon, France

P57 | SELONSERTIB (ASK1 INHIBITOR) IN SKIN TISSUE REPAIR OF OBESE MICE V. Oliveira Collares Barbos, B. Romana de Souza | Department of Histology and Embriology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

THE FACETED S100B PROTEIN: THE JEKYLL/HYDE SIDE F. Michetti | LUM University Casamassima, Genes Company, Roma, Italy

THE AUTOPHAGY-INDEPENDENT ROLE OF ATG7 IN REGULATING NEUROGENESIS Y. Shen, G. Wang | International Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou, China

UNRAVELING THE RELATIONSHIPS BETWEEN TUMOR CELLS AND THEIR MICROENVIRONMENT USING HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS M. Cordenonsi |Department of Molecular Medicine, University of Padova, Padova, Italy

THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

authors

reviewers

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17th International Conference of Histochemistry and Cytochemistry, 2025

All Items

FROM CLOUD TO BEDSIDE C. Tacchetti1,2 | 1Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; 2Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy

P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland

P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy

THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland

DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.

FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria

FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

Paul Nakane Prize Lecture | FROM NUCLEOLAR MORPHOLOGY TO MOLECULAR REGULATION OF GENE EXPRESSION BY PHASE SEPARATION P. Hozák | Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini1,2 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

A TECHNOLOGY PLATFORM FOR TRANSLATION OF ATMPS (ADVANCED THERAPY MEDICINAL PRODUCTS): THE EXAMPLE OF HUMAN EYE AND SKIN G. Pellegrini | Head of Cell Therapy Program Center for Regenerative Medicine Department of Life Sciences University of Modena e Reggio Emilia, Modena, Italy

ADVANCEMENTS AND EMERGING PERSPECTIVES IN MICROSCOPIC IMAGING S. Karahuseyinoglu | Department of Histology & Embryology, Koc University, School of Medicine, Istanbul, Turkiye

ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA

HUMAN AMNIOTIC MEMBRANE POTENTIAL FOR BONE REPAIR: FROM THE LAB TO THE CLINIC - ROLE OF ITS IMMUNOGENICITY F. Gindraux1,2 | 1CHU Besançon, Service de Chirurgie Maxillo-Faciale et Stomatologie, Besançon, France; 2Université Marie et Louis Pasteur, SINERGIES UR 4662, Besançon, France

P57 | SELONSERTIB (ASK1 INHIBITOR) IN SKIN TISSUE REPAIR OF OBESE MICE V. Oliveira Collares Barbos, B. Romana de Souza | Department of Histology and Embriology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

THE FACETED S100B PROTEIN: THE JEKYLL/HYDE SIDE F. Michetti | LUM University Casamassima, Genes Company, Roma, Italy

THE AUTOPHAGY-INDEPENDENT ROLE OF ATG7 IN REGULATING NEUROGENESIS Y. Shen, G. Wang | International Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou, China

UNRAVELING THE RELATIONSHIPS BETWEEN TUMOR CELLS AND THEIR MICROENVIRONMENT USING HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS M. Cordenonsi |Department of Molecular Medicine, University of Padova, Padova, Italy

THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

authors

reviewers

Categories

If and WoS

indexing

Keywords

FROM CLOUD TO BEDSIDE C. Tacchetti^1,2| ¹Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; ²Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy

IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini^1,2 | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

HUMAN AMNIOTIC MEMBRANE POTENTIAL FOR BONE REPAIR: FROM THE LAB TO THE CLINIC - ROLE OF ITS IMMUNOGENICITY F. Gindraux^1,2 | ¹CHU Besançon, Service de Chirurgie Maxillo-Faciale et Stomatologie, Besançon, France; ²Université Marie et Louis Pasteur, SINERGIES UR 4662, Besançon, France