LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS
T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Lipid droplets (LDs) are present in the nucleus, though much less abundant than cytoplasmic LDs. We investigated nuclear LDs generated in amino acid-deprived conditions, and found that diacylglycerol (DAG), produced by ATGL-mediated hydrolysis of triacylglycerol (TAG) in cytoplasmic LDs, flows into the inner nuclear membrane (INM) and gives rise to nuclear LDs. DAG in the INM is trafficked to PML nuclear bodies (PML NBs) via small vesicles, whose formation is abolished in PML knockout cells. These findings uncover a new class of vesicles in the nucleus that link PML NBs to TAG metabolism and prompt reconsideration of our understanding of the PML NB architecture.
Downloads
Citations
Supporting Agencies
-Data Availability Statement
OAHow to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
