FOR AUTHORS
Vol. 69 No. s2 (2025): 17th ICHC Conference, 2025 | Abstracts
Published:
21 August 2025
The Board of the Italian Society of Histochemistry has dedicated significant effort to identifying and contacting prestigious researchers to serve as keynote and invited speakers for this important event as well as Italian societies like GIC (Italian Society of Cytometry), GISN (Italian Group for the Study of Neuromorphology) and SIBS (Italian Society of Experimental Biology) for organizing joint sessions. Furthermore, all member societies of the IFSHC have been actively reached out to define and expand the Congress program. A particular mention must go to the Histochemical Society and to the Society for Histochemistry for their active contribution in organizing sessions. With a focus on ensuring a high-caliber scientific program, the team has successfully formulated a comprehensive agenda that includes plenary sessions, workshops, thematic panels, and poster sessions addressing the latest advancements in histochemistry and cytochemistry applied to medicine, biology, nanotechnology and artificial intelligence.
Professor Pavel Hozak, PhD, President, International Federation of Societies for Histochemistry and Cytochemistry | pavel.hozak@img.cas.cz
Professor Roberta Di Pietro, MD, President, Italian Society of Histochemistry and the Local Organizing Committee | r.dipietro@unich.it
17th International Conference of Histochemistry and Cytochemistry, August 27-30, 2025
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Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION S. Ferraioli, F. Sarigöl, K. Georgiou, N. Naetar, R. Foisner | Max Perutz Labs, Medical University Vienna, Austria
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David Glick Award Lecture | SUPER RESOLUTION MICROSCOPY: NEW APPROACHES TO DISCOVER THE TOPOGRAPHICAL SECRETS OF GENE REGULATION C. Cremer1,2,3 | 1Institute of Molecular Biology (IMB), Mainz, Germany; 2Max Planck Institute for Polymer Research, and for Chemistry, Mainz, Germany; 3Interdisciplinary Center for Scientific Computing (IWR), and Kirchhoff Institute for Physics, University Heidelberg, Heidelberg, Germany
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Paul Nakane Prize Lecture | FROM NUCLEOLAR MORPHOLOGY TO MOLECULAR REGULATION OF GENE EXPRESSION BY PHASE SEPARATION P. Hozák | Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini1,2 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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A TECHNOLOGY PLATFORM FOR TRANSLATION OF ATMPS (ADVANCED THERAPY MEDICINAL PRODUCTS): THE EXAMPLE OF HUMAN EYE AND SKIN G. Pellegrini | Head of Cell Therapy Program Center for Regenerative Medicine Department of Life Sciences University of Modena e Reggio Emilia, Modena, Italy
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ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA
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HUMAN AMNIOTIC MEMBRANE POTENTIAL FOR BONE REPAIR: FROM THE LAB TO THE CLINIC - ROLE OF ITS IMMUNOGENICITY F. Gindraux1,2 | 1CHU Besançon, Service de Chirurgie Maxillo-Faciale et Stomatologie, Besançon, France; 2Université Marie et Louis Pasteur, SINERGIES UR 4662, Besançon, France
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HUMAN AMNIOTIC EPITHELIAL CELLS FOR RETINAL REGENERATION: INVESTIGATING THEIR DIFFERENTIATIVE POTENTIAL IN VITRO R. Pisu1, S. Saponara2, S. Angioni2, E. Peiretti2, S.G. Vitale2, F. Marongiu1 | 1Department of Biomedical Sciences, University of Cagliari, Cagliari; 2Department of Surgical Sciences, University of Cagliari, Cagliari, Italy
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PERICYTE INVOLVEMENT IN THE PATHOGENESIS OF COLVI-RELATED MYOPATHIES: INSIGHTS INTO NG2–COLVI AXIS A. Fazio1, C. Evangelisti1, P. Sabatelli2, A. Cappellini1, A. Di Martino3, C. Faldini3, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, University of Bologna, DIBINEM, Bologna, Italy; 2CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza”, Unit of Bologna, Bologna, Italy; 3IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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THE AUTOPHAGY-INDEPENDENT ROLE OF ATG7 IN REGULATING NEUROGENESIS Y. Shen, G. Wang | International Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou, China
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UNRAVELING THE RELATIONSHIPS BETWEEN TUMOR CELLS AND THEIR MICROENVIRONMENT USING HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS M. Cordenonsi |Department of Molecular Medicine, University of Padova, Padova, Italy
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ROLE OF SCHWANN CELLS-CANCER CELLS CROSSTALK IN TUMOUR PROGRESSION C. Giampietri1, E. Pizzichini1, F. Somma1, S. Petrungaro1, A. Facchiano2, A. Filippini1, C. Fabrizi1, E. Gaudio1 | 1Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; 2Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
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CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti1, V. Serafin1, L. Antolini1, S. Bresolin2, L. Reggiani Bonetti3, S. Marmiroli1 | 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; 3Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy
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FILAMIN A IN BREAST CANCER: FROM LITERATURE TO FUNCTIONAL INSIGHTS P. Zawadka1, W. Arendt1, M. Gagat1,2, M. Izdebska1 | 1Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. 2Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland
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FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
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PATHOMICS – A NOVEL OMICS APPROACH FOR HISTOPATHOLOGY P. Boor1,2 | 1Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany; 2Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
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ACCELERATING DISCOVERY TOGETHER: A COMMUNITY APPROACH TO ANTIBODY VALIDATION AND MULTIPLEXED IMAGING A. Radtke | Leica Microsystems
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ANIMAL MODELS FOR LINEAGE TRACING IN (CELL) TRANSDIFFERENTIATION S. Cinti | Center for The Study of Obesity. Marche Polytechnic University, Ancona, Italy
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ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS S. Alberti | University of Messina, Messina, Italy
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THE USE OF BIOMIMETIC 2D AND 3D UROTHELIAL IN VITRO MODELS WITH MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF NORMAL AND CANCEROUS BLADDER TISSUE AS AN ALTERNATIVE METHOD IN PRECLINICAL STUDIES M.E. Kreft1, L. Tratnjek1, A. Janev1, N. Resnik1, U. Cerkvenik1, U. D. Jerman1, G. Markovič1, T.Ž. Ramuta1, T. Višnjar1, Ž. Sardoč1, A.Punčuh1, S. Kralj2, M. Čemažar3, P. Veranič1 |1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; 2Department for Materials Synthesis, Jožef Stefan Institute, Ljubljana, Slovenia; 3Institute of Oncology Ljubljana, Ljubljana, Slovenia
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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FROM BULK TO SELECTIVE: A JOURNEY THROUGH THE PHYSIOLOGICAL RELEVANCE OF AUTOPHAGY C. Settembre1,2 | 1 University of Naples Federico II, Naples, Italy; 2Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
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ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy
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THE EFFECT OF MUTANT HUNTINGTIN ON CLEAVAGE OF CREST BY CALPAIN-2 AND ITS CYTOTOXITY Y. Zhang, T. Peng, H. Li | Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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HACAT CELLS AS A 2D EXPERIMENTAL DIFFERENTIATING MODEL TO ANALYZE THE EARLY BIOLOGICAL EFFECTS INDUCED BY A PSORIATIC PROINFLAMMATORY MICROENVIRONMENT: CELL PROLIFERATION, DIFFERENTIATION AND FERROPTOSIS F. Riva1, S. Recalcati2, E. Gammella2, D. Daluiso1, F. Prignano3, E. Donetti2 | 1Dept. Public Health, Experimental and Forensic Medicine; Histology and Embryology Unit, University of Pavia, Pavia, Italy; 2Dept. Biomedical Sciences for Health, University of Milan, Milan, Italy; 3Dept. Health Sciences, Section of Dermatology, University of Florence, Florence, Italy
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FROM CLOUD TO BEDSIDE C. Tacchetti1,2 | 1Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; 2Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy
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USE OF HIGH-DEFINITION IMAGING FLOW CYTOMETRY AND A.I. TO ENUMERATE AND CHARACTERISE CIRCULATING TUMOUR CELLS S. Saravi1, S. Panfilov2, E. Karteris2 | 1College of Health, Medicine and Life Sciences, Brunel University of London, UK; 2College of Health, Medicine and Life Sciences, Brunel University of London, UK
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SUMOYLATION AS AN EARLY ADAPTIVE MECHANISM IN THE PROTEOMIC RESPONSE OF HUMAN GERM CELLS TO SIMULATED MICROGRAVITY A. Di Pauli1, G. Ricci2, M. Crescenzi3, M. A. Mariggiò4, C. Morabito4, L. Gesualdi1, M. Berardini1, F. Ferranti5, M. Signore6, A. Catizone1 | 1Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, Section of Histology and Embryology, «Sapienza» University, Rome, Italy; 2Department of Experimental Medicine, University «Luigi Vanvitelli», Naples, Italy; 3Core Facilities, Italian National Institute of Health, Rome, Italy; 4Department of Neuroscience, Imaging and Clinical Sciences CAST, «G. d’Annunzio» University, Chieti, Italy; 5Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; 6RPPA unit, Proteomics, Italian National Institute of Health, Rome, Italy
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FROM PIXELS TO DIAGNOSIS: A DEEP LEARNING FRAMEWORK FOR HISTOPATHOLOGICAL IMAGE ANALYSIS IN CANINE TESTICULAR PATHOLOGY L. Riccio1, E. Formisano2, M. De Falco3, S. Balsamo3, P. Formisano4, E. Di Napoli1, G. Piegari1, O. Paciello1, L. Rosati3 | 1Department of Veterinary Medicine and Animal Production, University of Naples “Federico II”, Naples, Italy; 2Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Postbus 616, The Netherlands; 3Department of Biology, University of Naples Federico II, Naples, Italy; 4Department of Translational Medicine, University Federico II, Naples, Italy
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THE MYSTERY OF INTERMEDIATE FILAMENTS: STRUCTURAL PERSPECTIVE O. Medalia | Deparment of Biochemistry, University of Zurich, Switzerland
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DOMAINS AND SIGNALLING PATHWAYS IN THE NUCLEUS L. Cocco | Department of Biomedical & Neuromotor Sciences, University of Bologna Medical School, Bologna. Italy
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LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS T. Fujimoto | Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.
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FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy
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LABELING EXTRACELLULAR VESICLES FOR HIGHLY SENSITIVE FLOW CYTOMETRY ANALYSES P. Simeone1,2, D. Brocco3, F. D’Ascanio1,2,4, D. De Bellis1,2, G. Colasante1,2, A. Aquilini-Mummolo1,2, T. Esmail1,2, A. Younas2, M. Filoso2, C. Cichella2, M. C. Cufaro5, A. Di Sebastiano5, D. Pieragostino6, S. Burattini7, M. Battistelli7, P. Del Boccio5, A. Fontana8, R. Di Pietro1, P. Lanuti1,2 | 1Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; 2Flow Cytometry Core Facility, Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” of Chieti-Pescara, Italy; 3Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 4Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy: 5Department of Science, University “G. d’Annunzio”, Chieti Pescara, Italy; 6Department of Innovative Technologies in Medicine and Dentistry, G. d’Annunzio University of Chieti-Pescara, Italy; 7Department of Biomolecular Sciences, University of Urbino, Urbino, Italy; 8Department of Pharmacy, University “G. d’Annunzio”, Chieti Pescara, Italy
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FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy
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EXPRESSION OF PIEZO1 IN CLEAR CELL RENAL CELL CARCINOMA: INSIGHTS FROM BIOINFORMATIC AND IMMUNOHISTOCHEMICAL ANALYSES D. Jerka1, P. Antosik2, K. Bonowicz1,3, D. Grzanka4, M. Gagat1,3 | 1Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland; 2Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland; 3Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland; 4Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
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TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti1, M. C. Gagliani2, G. Bellese2, M. Crippa3, A. Abbona4, M. Paccagnella4, P. Arnaldi5, M. C. Merlano6, O. Garrone7, A.M. Porcelli8, M. Matteoli1, P. Falletta9, P. Castagnola10, K. Cortese2 | 1IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; 2DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; 3Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; 4Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; 5IRCCS Ospedale Policlinico San Martino, Genova, Italy; 6Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; 7Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 8FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; 9Vita-Salute San Raffaele University, Milan, Italy; 10IRCCS Ospedale Policlinico San Martino, Genova, Italy
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SPATIO-TEMPORAL ORGANIZATION OF THE SUPER-ENHANCER STRUCTURE IN CANCER CELLS A. Chytła1, E. H. Lagunar1, R. Gonül1, B. Šalovská2, J. Červenka3, A. Miladinović4, L. Antiga4, P. Hozák4, M. Sztacho1 | 1Laboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; 2Yale Cancer Biology Institute, Yale University School of Medicine, West Haven, USA; 3Laboratory of proteomics, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; 4Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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ADVANCEMENTS AND EMERGING PERSPECTIVES IN MICROSCOPIC IMAGING S. Karahuseyinoglu | Department of Histology & Embryology, Koc University, School of Medicine, Istanbul, Turkiye
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IMAGING THE LYSOSOME IN CELLULAR SYSTEMS FOR DRUG DISCOVERY AND SCREENING V.A. Baldassarro1, M. Galeotti2, E. Satanassi3, L. Giardino1, L. Calzà4, C. Quadalti4 | 1DIMEVET, University of Bologna, Italy; 2IRET Foundation, Ozzano dell’Emilia, Bologna, Italy; 3Interdepartmental Centre for Industrial Research in Health Sciences and Technology ICIR-HST, University of Bologna, Ozzano dell’Emilia, Bologna, Italy; 4Fabit, University of Bologna, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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THE FACETED S100B PROTEIN: THE JEKYLL/HYDE SIDE F. Michetti | LUM University Casamassima, Genes Company, Roma, Italy
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES G. Di Sante1, A. M. Stabile1, A. Pistilli1, M. Ruggirello1,2, F. Michetti3,4, F. Ria2, M. Rende1 | 1 Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; 2Department of Translational Medicine and Surgery, Section of General Pathology, University “Cattolica del Sacro Cuore” of Rome, Roma, Italy; 3Department of Medicine, LUM University, Casamassima, Bari, Italy; 4Italy Genes, Rome, Italy
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ON THE WAY TO A NEW MODEL OF NEURODEGENERATION? FIRST EVIDENCE OF THE EXPRESSION OF GATA1 IN THE BRAIN: CORRELATIONS WITH AGING, MITOCHONDRIAL DAMAGE AND SYNUCLEINOPATHY C. Caturano1, F. E. Bellomi1, F. Arciprete1, V. Velardi1, L. La Barbera2, M. Falchi3, M. Bacioglu4, R. Mancinelli5, M. D’Amelio2, M. Spillantini4, M. Zingariello1, G. Vivacqua1,6 | 1Laboratory of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Rome, Italy; 2Laboratory of Molecular Neuroscience - Campus Biomedico University of Rome, Italy; 3National Centre for HIV/AIDS Research, Istituto Superior di Sanità, Rome, Italy; 4Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK; 5Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy; 6Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
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IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy
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NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy
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EXPLORING THE CYTOTOXIC AND APOPTOTIC ACTIVITIES OF PRUNUS SPINOSA ECOTYPE EXTRACT TRIGNO ON 3D AND 2D MODELS OF HUMAN CANCER CELLS A. Di Netta1, A. Di Pauli2, R. Vona3, C. Cittadini3, S. Meschini1, M. Condello1 | 1 National Center for Drug Research and Evaluation, National Institute of Health, Rome, Italy; 2 Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, «Sapienza» University of Rome, Rome, Italy: 3 National Center for Gender-Specific Medicine, National Institute of Health, Rome, Italy
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BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL V. Panella1, F. De Cecco2, S. Franceschelli1, M. A. Maggi3, S. Bisti4, A. Bravo Nuevo5, D. D’Ardes1, F. Cipollone1, L. Speranza1 | 1Department of Medicine and Aging Sciences, University «G. D’Annunzio», Chieti; 2Italian Institute of Technology, Genoa, Italy; 3Hortus Novus, L’Aquila, Italy; 4National Institute of Biostructure and Biosystem, Rome, Italy; 5Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, USA
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17th International Conference of Histochemistry and Cytochemistry, August 27-30, 2025
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P46 | ANALYSIS OF AQUAPORIN-2 MUTANT MICE T. Matsuzaki1, H. Yamamoto1, K. Sasaki2, H. Kogo1, A. Iizuka-Kogo1, M. Ikezawa1, Y. Tajika1 | 1Dept. of Anatomy and Cell Biology, Graduate School of Medicine, Gunma University, Maebashi, Japan; 2Bioresource Center, Graduate School of Medicine, Gunma University, Maebashi; Faculty of Bioresources and Environmental Science, Ishikawa Prefectural University, Nonoichi, Japan
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P47 | ASSESSMENT OF THE ANTI-INFLAMMATORY AND ANTIFIBROTIC EFFECTS OF HUMAN AMNIOTIC EPITHELIAL CELLS AFTER THEIR INTRATRACHEAL ADMINISTRATION IN A MOUSE MODEL OF BLEOMYCIN-INDUCED PULMONARY FIBROSIS E. Kolanko, A. Mazurski, A. Prusek, E. Bogunia, M. Hermyt, P. Czekaj | Department of Cytophysiology, Medical University of Silesia, Katowice, Poland
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P48 | NEW STRATEGIES TO IMPROVE THE RESPONSE OF AML CELLS TO TARGETED THERAPIES BY OVERCOMING THE PROTECTIVE EFFECT OF THE BONE MARROW MESENCHYMAL STEM CELLS G. Mazzanti1, F. Liccardo2, L. Pace1, M. Marcotulli3, L. Lafrate3, G. Cidonio3, T. Ottone4, S. Travaglini4, M.T. Voso4, V. Fulci5, M. Sampaolesi1, F. Fazi1, S. Masciarelli1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences and Medical Embryology, Section of Histology Sapienza University of Rome, Rome, Italy; 2Centre de Recherches en Cancérologie de Toulouse, Inserm/ U1037, Université de Toulouse, Toulouse, France; 3Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy; 4Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; 5Department of Molecular Medicine, Sapienza, University of Rome, Rome, Italy
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P49 | DEVELOPMENT OF AN INJECTABLE AND SELFASSEMBLING SCAFFOLD FOR THE DIRECT DELIVERY OF CARDIAC EXTRACELLULAR MATRIX AND CARDIAC PROGENITOR CELLS A. Menini1, V. Romano1, A. M. Sacco1, D. Nurzynska2, G. Ricci3, C. Amarelli4, C. Castaldo1, F. Di Meglio1 | 1Department of Public Health, University of Naples «Federico II», Naples, Italy; 2Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi; 3Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy; 4Department of Cardiac Surgery and Transplants, Monaldi Hospital, Naples, Italy
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P50 | OPTIMIZATION OF A RAPID AND EFFICIENT DECELLULARIZATION PROTOCOL FOR COMPOSITE VASCULARIZED FACIAL GRAFT FABRICATION A. Menini1, A. M. Sacco1, V. Romano1, D. Nurzynska2, G. Ricci3, S. La Padula1, F. Schonauer1, C. Castaldo1, F. Di Meglio1 | 1Department of Public Health, University of Naples «Federico II», Naples, Italy; 2Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; 3Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy
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P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY A. Mileo1, S. Boccia2, E. Del Genio1, R. Pastore1, M. De Falco3, I. Belviso4 | 1Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 2Dept. of Biology, University of Naples Federico II, Naples, Italy; 3Dept. of Biology, University of Naples Federico II, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; 4Dept. of Wellness, Nutrition and Sport, Telematic University Pegaso, Naples, Italy
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P52 | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL EVALUATION OF THE ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF HEMP EXTRACTS ON THE LIVER OF RATS INVOLVED IN INFLAMMATION CAUSED BY LPS A. Miller1, M. Kotanska2, M. Bednarski2, G.P. Lombardo3, V. Natale3, G. Pirracchio3, L. Spiccia3, S. Pergolizzi3, G. Rizzo4, E.R. Lauriano3 | 1Department of Veterinary Sciences, University of Messina, Messina, Italy; 2Department of Pharmacological Screening, Jagiellonian University Medical College, Kraków, Poland: 3Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; 4Department of Clinical and Experimental Medicine, University of Messina, Italy
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P53 | CIRCADIAN DEPENDENT MOTILITY: THE ROLE FOR THE PERINUCLEAR ACTIN CAP E. Montacci1, M. Sgarzi2, L. Dall’Olio3, E. Giampieri4, D. Romaniello4, M. Lauriola5 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Laboratory of Data Science and Bioinformatics, IRCSS Institute of Neurological Sciences, Bellaria Hospital, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 5Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS L. Morello1, G. Stati1, V. Giansante1, S. Lattanzio1, P. Cerritelli1, D. Bruni1, S. Cinti2, R. Di Pietro1,3,4 | 1Department of Medicine and Aging Sciences, “G. d’ Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Experimental and Clinical Medicine, Center of Obesity, Polytechnic University of Marche, Ancona, Italy; 3StemTeCh Group, G. d’ Annunzio Foundation, “G. d’ Annunzio” University of Chieti Pescara, Chieti, Italy; 4Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
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P55 | ENDOTHELIAL THYMIDINE PHOSPHORYLASE DEFICIENCY TRIGGERS MORPHO-FUNCTIONAL DEGE-NERATION OF ENTERIC NEURONS AND REDUCES INTESTINAL STEM CELL PROLIFERATION I. Neri1, E. Boschetti1, T. Saha2, S. Rommel2, S. Schulte2, M. Gries2, R. De Giorgio3, L. Manzoli1, S. Ratti1, K. Schäfer2 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Workgroup Enteric Nervous System (AGENS), Department of Informatics and Microsystems Technology, University of Applied, Sciences Kaiserslautern, Zweibrücken, Germany; 3Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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P56 | HISTOLOGICAL PROFILE OF INACTIVE UNILATERAL CONDYLAR HYPERPLASIA: EVIDENCE OF BORDERLINE TISSUE ACTIVITY F. Nicita1, G. Vermiglio1, J. Freni1, A. Centofanti1, D. Labellarte1, R. Briganti1, G.P. Anastasi1, G. Cutroneo1, A. Favaloro1, M. Runci Anastasi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy
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P57 | SELONSERTIB (ASK1 INHIBITOR) IN SKIN TISSUE REPAIR OF OBESE MICE V. Oliveira Collares Barbos, B. Romana de Souza | Department of Histology and Embriology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
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P58 | VITAMIN D ATTENUATES LIVER INJURY BY REDUCING APOTOSIS, PYROPTOSIS, FERROPTOSIS AND PROMOTING REGENERATION IN TYPE 2 DIABETES S. Rzeyeva1, N. Bayromava2, T. Ozbilenler1, A. Akdemir3, M. Anapalı Aykaç4, D. Aydemir5, F. Kaya Dagistanli1, T. Ulutin1, O. Uysal1, M. Ozturk6 | 1Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye; 2Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye; 3Karabuk University, Faculty of Medicine, Karabük, Türkiye; 4Ataturk University, Faculty of Medicine, Erzurum, Türkiye; 5Istanbul University, Faculty of Medicine, Istanbul, Türkiye; 6Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul Türkiye
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P59 | IMMUNOHISTOCHEMISTRY ANALYSIS TO DETECT A MOLECULAR SIGNATURE IN INTERVERTEBRAL DISC DEGENERATION L. Penolazzi1, R. Nadalini1, C. Sief1, E. Lambertini2, C. Angelini3, R. Piva1 | 1Department of Neurosciences and rehabilitation, University of Ferrara, Italy; 2Laboratorio Centralizzato di ricerca preclinica, University of Ferrara, Italy; 3Department of Translational Medicine, University of Ferrara, Italy
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P60 | UNDERSTANDING HUMAN INTERVERTEBRAL DISC HOMEOSTASIS: 3D EXPERIMENTAL MODELS L. Penolazzi1, A. Chierici1, R. Nadalini1, E. Lambertini2, C. Nastruzzi3, G. Lisignoli4, C. Manferdini4, G. D’Atri4, R. Piva1 | 1Department of Neurosciences and rehabilitation, University of Ferrara, Italy; 2Laboratorio centralizzato di ricerca preclinica, University of Ferrara, Italy; 3Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Italy; 4Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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P61 | IMMUNOPROFILE OF MERKEL CELLS IN THE HUMAN VAGINAL EPITHELIUM S. Polakovičová1, M. Borovský2, L. Maršík2, B. Filová3, I. Varga3, L. Sallicandro4 | 1Inst. of Hist. and Embr. MFCU in Bratislava, Bratislava, Slovakia; 21st Obst. and Gyn. Dep. FMCU with Repr. Med. Centre Hospital, Bratislava, Slovakia; 3Inst. of Hist. and Embr. MFCU in Bratislava, Bratislava, Slovakia; 4Dep. of Medicine and Surgery, University of Perugia, Perugia, Italy
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P62 | FFAR4/GPR120 ACTIVATION COUNTERACTS FIBROGENIC PATHWAYS IN A CHOLESTATIC LIVER INJURY MODEL S. Pompili1, R. Sferra1, F. Ronca1, A. Cappariello2, A. Vetuschi1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; 2Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy
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P63 | ROLE OF ION CYCLOTRON RESONANCE ON BODY ELECTRICAL IMPEDANCE IN CHRONIC PAIN: CLINICAL EFFECTS AND FUTURE PERSPECTIVES L. Prosperi1, G. Barassi1, M. Panunzio2, P. Spaggiari3, P.E. Gallenga1 | 1Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Responsible Research Hospital, Campobasso, Italy; 3Scientific Association of Integrated Biochemical and Biophysical Medicine (A.M.B.B.), Mantova, Italy
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P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri1, M.V. Marvi1, V. Righi2, V. Papa3, E. Boschetti1, S. Blando1, E. Franceschi4, M. Zoli4, D. Mazzatenta4, N. Neri4, A. Vignaroli4, L. Cocco1, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Sciences, University of Bologna, Bologna, Italy; 3IRCCS St. Orsola, Bologna, Italy; 4IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
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P65 | (YS) INVESTIGATING THE EFFECTS OF THE SECRETOME FROM HUMAN AMNIOTIC MESENCHYMAL STROMAL CELLS ON INFLAMMASOME ACTIVATION M. Rossi1, M. Magatti2, P. Romele2, E. Vertua2, E. Giuzzi2, S. Farigu2, L. Marelli2, B. Rapuzzi2, S. De Munari2, A. Silini2, O. Parolini3 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, and Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 2Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 3Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy & Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy
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P66 | FROM INNERVATION TO STEROIDOGENIC DEFECT: IMPLICATIONS OF CGRP IN THE PATHOPHYSIOLOGY OF POLYCYSTIC OVARY SYNDROME L. Sallicandro1, R. Gentile2, B. Filová3, S. Polakovičová3, A. Biagini1, F. Ballarino4, D. Del Bianco4, I. Varga5, A. Malvasi6, B. Fioretti2 | 1Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 3Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 4Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 5Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 6Department of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Unit, University of Bari Aldo Moro, Bari, Italy
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P67 | EMERGING ROLE OF NUCLEAR PHOSPHOLIPASE C BETA 1 AS POTENTIAL BIOMARKER IN LUNG CANCER S. Salucci1, I. Versari1, S. Burattini2, D. Montecchio3, I. Faenza1 | 1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 2Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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P68 | EARLY EFFECTS OF MECHANOACUSTIC FOCUSED VIBRATION (MFV) ON PRIMARY HUMAN SATELLITE CELLS ISOLATED FROM YOUNG AND OLDER INDIVIDUALS S. Sancilio1, G. Stati1, E.S. Di Filippo2, S. Fulle2, R. Di Pietro1 | 1Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Neuroscience Imaging and Clinical Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
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P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo1, V. Gallicchio1, A. Lallo1, F. Carrella1, D. Barbarisi2, A. Falzarano1, M. De Falco3, F. Flora2, A. Peluso2, S. Piccolo2, L. Flora2 | 1Department of Science and Technologies, University of Sannio, Italy; 2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; 3Department of Biology, University of Naples, Italy
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P70 | TRICHOSANTHIN TARGETS WNT/NF-KB PATHWAYS TO ATTENUATE PSORIATIC INFLAMMATION AND KERATINOCYTE HYPERPROLIFERATION K. Wang1, W. Li1, Z. Ying1, C. Li2, O. Sha1 | 1Department of Anatomy and Histology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, China; 2Department of Anatomy, Shantou University Medical College, Shantou, China
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P71 | THE EXTRACELLULAR VESICLE POPULATIONS UNDERWENT ALTERATIONS SUBSEQUENT TO THE PRETREATMENT OF ADIPOSE-DERIVED STEM CELLS WITH MELATONIN RECEPTOR AGONIST B. Sikora, K. Pogoda-Mieszczak, E. Bogunia, A. Skubis-Sikora, P. Czekaj | Department of Cytophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland
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P72 | A SWAB NEGATIVE PATIENT AFTER SARS-COV-2 INFECTION DISPLAYS INCREASE OF VEGF AND FIBRONECTIN ASSOCIATED WITH ALTERATIONS OF INTERCELLULAR JUNCTIONS C. Simioni1, J.M. Sanz2, R. Gafà3, G. Cenacchi4, S. Occhionorelli3, R. Rizzo5, D. Bortolotti5, A. Passaro3, L.M. Neri3 | 1Department of Life Sciences and Biotechnology, University of Ferrara, Italy; 2Department of Chemical, Pharmaceutical and Agricultural, Sciences, University of Ferrara, Italy; 3Department of Translational Medicine, University of Ferrara, Italy; 4Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Italy; 5Department of Environmental and Prevention Sciences, University of Ferrara, Italy
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P73 | ANALYSIS OF SAPK/JNK PATHWAY IN DOXORUBICIN INDUCED ADIPOSE-DERIVED STEM CELL CYTOTOXICITY A. Skubis-Sikora, B. Sikora, K. Pogoda-Mieszczak, E. Bogunia, P. Czekaj | Department of Cytophysiology, Chair of Histology and Embryology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland
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P74 | EXPRESSION OF PISCIDIN, TLR-4, ERK2 AND P-P38 MAPK IN THE ZEBRAFISH GUT EXPOSED TO PCB-126 AND POSSIBLE PROTECTIVE EFFECTS OF GINESTEIN L. Spiccia1, A. Miller2, G.P. Lombardo1, V. Natale1, F. Pellicanò1, S. Marino1, A. Nunnari1, A. Migliorato3, E.R. Laurian1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Department of Biomedical and Dental Sciences and Morphofunctional Images, University of Messina, Messina, Italy
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P75 | MICROBIOTA-GUT-BRAIN AXIS IN AN AUTISM SPECTRUM DISORDER ANIMAL MODEL F. Sulas1, G. Cominelli1, G. Favero1,2, D. Pinto2,3, F. Rinaldi2,3, R. Rezzani1,2,4 | 1Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; 2Interdepartmental University Center of Research Adaption and Regeneration of Tissues and Organs (ARTO), University of Brescia, Brescia, Italy; 3Human Microbiome Advanced Project Institute, Milan, Italy; 4Italian Society for the Study of Orofacial Pain (Società Italiana Studio Dolore Orofacciale - SISDO), Brescia, Italy
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P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
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P77 | MEMBRANE SKELETAL PROTEIN, MEMBRANE PALMITOYLATED PROTEIN 6 (MPP6), IN MOUSE CEREBRAL SYNAPSES N. Terada1, Y. Saitoh2, S. Motofuji3, A. Kamijo4, T. Suzuki5, T. Yoshizawa6, T. Sakamoto7, K. Kametani8 | 1Health Science Division, Shinshu University Graduate School of Medicine, Science and Technology, Japan; 2Center for Medical Education, Teikyo University of Science, Japan; 3Division of Biosciences, Teikyo University of Science Graduate School of Science & Engineering, Japan; 4Division of Basic & Clinical Medicine, Nagano College of Nursing, Japan; 5Department of Molecular and Cellular Physiology, Shinshu University Academic Assembly Institute of Medicine, Japan; 6Division of Animal Research, Research Center for Advanced Science and Technology, Shinshu University, Japan; 7Department of Cancer Biology, Institute of Biomedical Science, Kansai Medical University, Japan; 8Health Science Division, Shinshu University Graduate School of Medicine, Science and Technology, Japan
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P78 | THE ROLE OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STROMAL CELLS IN MYOFIBER REGENERATION A. Longhin1, V. Gatta2, G. Teti2, C. Sassoli3, F. Chellini3, A. Tani3, M. Parigi3, R. Garella3, F. Palmieri3, R. Squecco3, M. Mattioli Belmonte4, C. Licini4, A. La Contana4, S. Zecchi Orlandini3, M. Falconi1 | 1Dep. Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Dep. Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; 3Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 4Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy
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P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE V. Bellitto1, F. Grasselli1, L. Lucernoni1, I. Martinelli2, E. Vittadini1, A.M. Eleuteri1, L. Bonfili1, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy
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P80 | MITOCHONDRIA-LYSOSOME INTERACTIONS: EMERGING PLAYERS IN GLIOMA L. Zeppa1, M.B. Morelli2, C. Aguzzi2, M. Giangrossi2, M. Nabissi2, G. Cameli2, G. Santoni2, S.K. Tayebati2, V. Bellitto1, D. Tomassoni1, C. Amantini1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Pharmacy, University of Camerino, Camerino, Italy
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P81 | AN IN VITRO CYTOTOXIC, PROAPOPTOTIC AND ANTITUMOR ACTIVITY ASSESSMENT FOR CERAMIDASE INHIBITORS ON HUMAN LARYNGEAL CANCER CELLS C. Vejselova Sezer1, M. Cengiz2, B. Gür3, R. Dündar4, C. Cingi5, H.M. Kutlu6 | 1Department of Biology, Kutahya Dumlupinar University, Kutahya, Türkiye; 2Department of Mathematics and Physical Sciences Education, Siirt University, Siirt, Türkiye; 3Department of Biochemistry, Iğdır University, Iğdır, Türkiye; 4Department of Otorhinolaryngology, Acibadem Eskişehir Hospital, Eskişehir, Türkiye; 5Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskişehir, Türkiye; 6Department of Biology, Eskişehir Technical University, Eskişehir, Türkiye
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P82 | PROINFLAMMATORY BONE MARROW NICHES AND NEUTROPHIL ACTIVATION ARE ASSOCIATED WITH TIGIT EXPRESSION IN MULTIPLE MYELOMA V. Velardi1, F. Arciprete1, V. Tomarchio2, G. Vivacqua1, M.A. Tafuri2, M. Di Cecca2, L. Rigacci2, A. Crescenzi3, R. Rana1, O. Annibali2, M. Zingariello1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Unit of Hematology, Stem Cell Transplantation, University Hospital Campus Bio-Medico Rome, Italy; 3Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy
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P83 | INFLAMMATORY PROFILE IN SKIN, LUNG, AND KIDNEY OF A HOCL-INDUCED MURINE MODEL OF SYSTEMIC SCLEROSIS: AN IMMUNOHISTOCHEMICAL STUDY G. Vermiglio1, J. Freni1, F. Nicita1, A. Centofanti1, D. Labellarte1, E. Rizzuto1, A. Favaloro1, M. Runci Anastasi2, G.P. Anastasi1, G. Cutroneo1 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy
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P84 | OMOMYC PEPTIDE LOCALIZES IN THE NUCLEUS AND DISPLAYS ANTIPROLIFERATIVE EFFECTS ON CELLULAR MODELS OF HUMAN OSTEOSARCOMA I. Versari1, S. Salucci1, A. Bavelloni2, M. Traversari3, I. Faenza1 | 1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 2Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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P85 | ALTERATION OF SUBMUCOSAL AND MYENTERIC GANGLIA IN SEVERE GUT DYSMOTILITY: A QUANTITATIVE MORPHOMETRIC ANALYSIS H. Yaghi1, E. Boschetti1, S. Blando1, I. Neri1, C. Malagelada2, R. De Giorgio3, L. Manzoli1, S. Ratti1 | 1Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum, University of Bologna, Bologna, Italy; 2Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain; 3Department of Translational Medicine, Università di Ferrara, Ferrara, Italy
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P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES I. Atasoy1, S. Yilmazer2, D. Gezen Ak3, E. Dursun3 | 1Medical Biology Department, İstabul University-Cerrahpasa Faculty of Medicine Istanbul, Türkiye; 2Department of Medical Biology Halic University, Faculty of Medicine, Istanbul, Türkiye; 3Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Türkiye
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P87 | EVALUATION OF SPEXIN AND KISSPEPTIN EXPRESSIONS IN ADIPOSE TISSUES OF WISTAR ALBINO RATS DURING PUBERTY A.H. Yozgat1, D. Billur1, B.I Erguder2, A. Ucar3 | 1Ankara University Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye; 2Ankara University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye; 3University of Health Sciences, Sisli Hamidiye Etfal Health Practices and Research Centre, Department of Pediatric Endocrinology and Diabetes, Istanbul, Türkiye
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P88 | REGENERATIVE MEDICINE, REHABILITATION AND CYTO-HISTOCHEMISTRY: RECENT EVALUATIONS OF INTEGRATED TREATMENTS L. Gatta1,2, M. Ceccarelli1,3, C. Del Gaizo1 | 1BIORI, Academy of Bioregenerative Medicine and Surgery; Rome, Italy; 2Catholic University of Rome, Policlinico Gemelli, Rome, Italy; 3International Center for Study and Research in Physiological and Aesthetic Medicine (Ae. Phy. Med. Centre), Rome, Italy.
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P01 | PUTATIVE EFFECTS OF THE HYDROGEL-STEM CELL-MELATONIN COMBINATION WITH OR WITHOUT A SCAFFOLD TO TREAT THIOACETAMIDE-INDUCED LIVER DEGENERATION IN RAT G. Ozgun1, D. Yucel2, M. Kolgazi3, S. Ozer4, N. Tozun5, S. Arbak6 | 1Dept of Medical Biotechnology, Institute of health sciences, Acibadem Univ, Istanbul, Türkiye; 2Dept. of Histology and Embryology, School of Medicine, Acibadem Univ, Istanbul, Türkiye; 3Dept. of Physiology, School of Medicine, Acibadem Univ., Istanbul, Türkiye; 4Animal Application and Research Center, Acibadem Univ. Istanbul, Türkiye; 5Dept. of Gastroenterology, School of Medicine, Acibadem Univ., Istanbul, Türkiye; 6Dept. of Histology and Embryology, School of Medicine, Acibadem Univ., Istanbul, Türkiye
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P02 | THE C-C CHEMOKINE-RECEPTOR 2 (CCR2)/CCL2 AXIS PARTICIPATE IN PLATELET FUNCTION IN MYELOFIBROSIS F. Arciprete1, V. Velardi1, G. Pozzi2, C. Carubbi3, S. Cortellazzi3, A.M. Vannucchi4, M. Vitale5, R.A. Rana1, G. Vivacqua1, E. Masselli3, M. Zingariello1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Anatomy Unit, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy; 3Anatomy Unit, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy; 4Center Research and Innovation of Myeloproliferative Neoplasm, University Hospital Careggi, University of Florence, Florence, Italy; 5San Raffaele University, Milano, Italy
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P03 | THE ROLE OF FILAMIN A IN REGULATING BREAST CANCER CELL BEHAVIOR AND TUMOR MICROENVIRONMENT INTERACTIONS W. Arendt1, P. Zawadka1, M. Hałas-Wiśniewska1, M. Gagat2, M. Izdebska1 | 1 Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń, Poland; 2Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland
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P04 | CYTOCHEMICAL AND BIOLOGICAL EFFECT OF BIORESONANCE IN IRRITABLE BOWEL SYNDROME G. Barassi1, M. Panunzio2, P.E. Gallenga1 | 1Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Responsible Research Hospital, Campobasso, Italy
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P05 | ENTERIC NERVOUS SYSTEM NEUROPLASTICITY IN COLON OF ANIMAL MODELS OF OBESITY V. Bellitto1, I. Martinelli2, G. Nittari2, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
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P06 | MICROGRAVITY-INDUCED CHANGES IN CYTOSKELETON STRUCTURE OF TCAM-2 CELLS M. Berardini1, L. Gesualdi1, A. Di Pauli1, M. Signore2, S. Broccolucci1, F. Ferranti3, M. Bizzarri4, M. Tafani4, G. Ricci5, A. Catizone1 | 1Dept of Anatomy, Histology, Forensic-Medicine and Orthopedics,“Sapienza” University of Rome, Rome, Italy; 2RPPA Unit, Proteomics Area, Core Facilities, Istituto Superiore di Sanità, Rome, Italy; 3Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; 4Dept of Experimental Medicine “Sapienza” University of Rome, Rome, Italy; 5Dept of Experimental Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy
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P07 | DISRUPTED GUT-VASCULAR BARRIER AND INFLAMMATORY REMODELING IN MNGIE: A SPATIAL TRANSCRIPTOMIC AND HISTOLOGICAL STUDY S. Blando1, E. Boschetti1, I. Neri1, L. Caporali2, C. Fiorini2, D. Ormanbekova2, C. Malagelada3, I. Rusciano1, V. Carelli2, R. De Giorgio4, L. Manzoli1, S. Ratti1 | 1Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum, University of Bologna, Italy; 2IRCCS Institute of Neurological Sciences of Bologna, Neurogenetics Program, Bologna, Italy; 3Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain; 4Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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P08 | COMBINED EFFECTS OF NONYLPHENOL AND STEROID HORMONES ON HUMAN PROSTATE CELL LINE S. Boccia1, A. Mileo2, F. Carrella3, R. Sciarrillo4, A. Capaldo1, M. De Falco5 | 1Dept. of Biology, University Federico II of Naples, Naples, Italy; 2Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 3Dept. of Science and Technologies, University of Sannio, Benevento, Italy; 4Dept. of Science and Technologies, University of Sannio, Benevento, Italy; 5Dept. of Biology, University Federico II of Naples,; National Institute of Biostructures and Biosystems (INBB), Rome, Italy
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P09 | EFFECTS OF NUTLIN-3A ACTIVITY ON 2D AND 3D RETINOBLASTOMA MODELS F. Bompan1, R. Foschi2, A. Dipinto3, F. Casciano2, G. Lodi4, A. Sanvido5, P. Severi4, L. Giari1, L. C. Cosenza5, R. Voltan2, A. Romani4 | 1Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; 2Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; LTTA Centre, University of Ferrara, Ferrara, Italy; 3Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; 4Department of Translational Medicine, University of Ferrara, Ferrara, Italy; LTTA Centre, University of Ferrara, Ferrara, Italy; 5Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy
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P11 | DOMINO TRANSPLANTATION IN MNGIE: IS THE LIVER A SUITABLE GRAFT? E. Boschetti1, I. Neri1, S. Blando1, C. Malagelada2, L. Caporali3, R. D’Angelo4, R. Rinaldi4, S. Mongiorgi1, V. Carelli3, R. De Giorgio5, L. Manzoli1, S. Ratti1 | 1Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum – University of Bologna, Italy; 2Digestive System Research Unit, University Hospital Vall d’Hebron; Barcelona, Spain; 3IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 4IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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P12 | VISUALIZING NUCLEAR ARCHITECTURE DURING MAMMAL ERYTHROPOIESIS C. Casali, M. Cavallo, S. Bellei, A. Diaf, L. Giulini, D. Tunesi, G. Milanesi, M. Biggiogera | Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy
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P13 | MORPHO-FUNCTIONAL DIFFERENCES IN THE GUT OF AGED MICE WITH THE POSSIBLE EFFECTS OF ANTI-INFLAMMATORY TREATMENTS A. Casini1, S. Leone1, R. Mancinelli1, R. Vaccaro1, M. Catalano2, G. D’Alessandro2, A. Rinaldi2, A. Reccagni2, G. Vivacqua3, A. Franchitto4, P. Onori1, C. Limatola2, E. Gaudio1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; 2Department of Physiology and Pharmacology, Sapienza University of Rome, Italy; 3Department of Medicine and Surgery, University Campus BioMedico of Rome, Italy; 4Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome «Foro Italico», Rome,Italy
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P14 | THE ROLE OF CHROMATIN REORGANIZATION IN HYPOXIA ADAPTATION M. Cavallo1, C. Casali1, L. Giulini1, A. Dia1, D. Tunesi1, G. Milanesi1, G. Mazzini2, M. Biggiogera1 | 1Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia; Italy; 2Institute of Molecular Genetics, National Research Council (IGMCNR), Pavia, Italy
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P15 | PHB/JAK/H3Y41PH AXIS REGULATES MEIOTIC RECOMBINATION IN SPERMATOGENESIS H. Chen1, L. Zhang1, W. Tan-Tai1, M. Liu2, H. Shi3, W. O4, P.A. Martin-DeLeon5 | 1Department of Anatomy, Histology & Embryology, Shanghai Medical College, Fudan University, Shanghai, China; 2State Key Laboratory of Molecular Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China; 3NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China; 4School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China; 5Department of Biological Sciences, University of Delaware, Newark, USA
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P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER P. Chiodelli1, J. Romoli1, P. Bonassi Signoroni2, E. Vertua2, C. Ferrari3, E. Giuzzi2, A. Paini2, E. Scalvini2, A. Papait1, F.R. Stefani2, A. R. Silini2, O. Parolini1 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 3Research and Clinical Trials Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy
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P17 | INTERMITTENT FASTING AND FUCOIDAN ADMINISTRATION AMELIORATE THE EFFECT OF TYPE 2 DIABETES ON ENTERIC NERVOUS SYSTEM IN RATS A.M. Cırık¹, B. Erdem¹, E. Akar ¹, E. Akkuş¹, Ö. İleri-Meşe², H. Maraş², Z.N. Özdemir-Kumral³, M. Yüksel⁴, Ö.T. Çilingir-Kaya² | 1Marmara Uni School of Medicine, Istanbul, Türkiye; 2Department of Histology and Embryology, Marmara Uni School of Medicine, Türkiye; 3Department of Physiology, Marmara Uni Faculty of Medicine, Türkiye; 4Department of Medical Laboratory Techniques, Vocational School of Health Services, Marmara Uni, Türkiye
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P18 | NESTIN EXPRESSION IN THE MYOCARDIUM OF SPONTANEOUSLY HYPERTENSIVE RATS AND CONPLASTIC SHR-MTBN STRAIN, AND CO-EXPRESSION WITH CONNEXIN 43 D. Cizkova1, J. M. Zurmanova2, T. Artykov1, F. Galatik2, B. Elsnicova2, J. Silhavy3, M. Pravenec3, J. Mokry1 | 1Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; 2Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; 3Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
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P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
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P20 | RNASEQ AND HISTOCHEMICAL STAININGS ASSESS BIOCHEMICAL AND STRUCTURAL CHANGES IN THE MOUSE INTERVERTEBRAL DISC ACROSS THE LIFESPAN A. Hallmark1, A. Ali2, C. Dahia3 | 1Hospital for Special Surgery, New York, USA; 2Department of Medicine, Columbia University, New York, USA; 3Hospital for Special Surgery, Weill Cornell Medicine
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P21 | EARLY BIOLOGICAL EFFECTS ON CELL PROLIFERATION AND DIFFERENTIATION INDUCED BY EXTRACELLULAR MICROVESICLES (EVS) DERIVED FROM HUMAN KERATINOCYTES IN PSORIATIC MICROENVIRONMENT D. Daluiso1, B. Barco1, C. Porro2, E. Donetti3, F. Riva1 | 1Department of Publich Health, Experimental and Forensic Medicine, Histology and Embryology Unit, University of Pavia, Pavia, Italy; 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 3Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
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P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira1, S. Grassilli2, M. Pierantoni1, V. Bertagnolo1, F. Brugnoli1 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy
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P23 | CALRETININ IMMUNOREACTIVE NON-TRADITIONAL LARGE NEURONS IN THE GRANULAR LAYER OF THE HUMAN CEREBELLAR CORTEX P. Flace1, M. E. Caringella2, D. Galletta3, G. Santangelo3, C. Caporusso2, M. Stolfa2, A. Cacciola4, J.J.V. Branca5, G. Agazzino2, R. Gradini6, P. Livrea7, A. Marzullo2 | 1Medical School, University of Bari ‘Aldo Moro’, Bari, Italy; 2Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, Italy; 3Department of Psychology, Specialization School of Neuropsychology. University of Campania ‘Luigi Vanvitelli’, Caserta, Italy; 4Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 5Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy; 6Department of Experimental Medicine, Sapienza University, Roma, Italy; 7University of Bari ‘Aldo Moro’, Bari, Italy
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P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia1, C. Girone1, D.M. Filippini2, G. Querzoli3, M. Fermi4, S. Venturoli5, A. Degiovanni6, C. Miroglio1, E. Montacci1, A. Ardizzoni7, M. Lauriola8, D. Romaniello8 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; 6Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; 7Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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P25 | RESPONSE TO HEDGEHOG AND PI3K/AKT/MTOR PATHWAY INHIBITORS IN PREB-ALL: ANALYSIS OF THE INTRACELLULAR DISTRIBUTION OF PATHWAY ENZYMES AND OF THE AUTOPHAGY PROCESS M. Sicurella1, M. De Chiara2, E. Battaglia2, F. Franco2, M. De Vita2, L.M. Neri2 | 1Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; 2Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION J. Freni1, M. Crescenti2, E. Bertuccio3, A. Fittipaldi1, P. Carrega2, E. Di Carlo4, G. Ferlazzo3, G. Vermiglio1, I. Bonaccorsi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy: 2Department Human Pathology, «G. Barresi», University of Messina, Messina, Italy; 3Department of Experimental Medicine (DIMES), University of Genoa, Genova, Italy; 4Department of Medicine and Sciences of Aging, «G. D’Annunzio» University of Chieti-Pescara, Chieti, Italy
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P27 | HISTOCHEMICAL APPROACHES FOR EVALUATING THE REPRODUCTIVE HEALTH OF MUSSEL MYTILUS GALLOPROVINCIALIS EXPOSED TO ACUTE THERMAL STRESS M. Galati, M. A. Oueldi, M. Romeo, T. Cappello, M. Maisan | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
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P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante1, L. Leanza2, E. Guerra3, F. Vianello4, C. Iacovino1, S. Lattanzio1, L. Morello1, G. Stati1, P. Simeone3, P. Lanuti3, S. Alberti5, M. Reichert6, R. Di Pietro1 | 1Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Biology, University of Padua, Padua, Italy; 3Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; 4Department of Biology, University of Padua, Padua, Italy; 5Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; 6Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany
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P29 | GLUTAMATERGIC MODULATION OF HYPOTHALAMIC RSPONDIN3 NEURONS UNDER PHYSIOLOGICAL CONDITIONS D. Gok Yurtseven1, G. Topal1, N. Hasanoglu Akbulut2, D. Udum3, M. Yalcın4, O. Eyigor1 | 1Department of Histology and Embryology, Bursa Uludag University, Faculty of Medicine, Bursa, Türkiye; 2Department of Histology and Embryology, Canakkale Onsekiz, Mart University, Faculty of Medicine, Canakkale, Türkiye; 3Department of Biochemistry, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Türkiye; 4Department of Veterinary Physiology, Bursa Uludag University, Faculty of Veterinary Medicine, Bursa, Türkiye
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P30 | NEW INSIGHT IN THE IN VITRO-GENERATION OF INSULIN-PRODUCING CELLS: VAV1 AS A REGULATOR OF PDX1 AND MIR-375 LEVELS DURING DIFFERENTIATION OF HIPSCS INTO Β-CELLS M. Pierantoni1, F. Brugnoli1, V. Zamarian2, M. Dell’Aira1, V. Sordi2, V. Bertagnolo1, S. Grassilli3 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy
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P31 | MORPHOLOGICAL AND ULTRASTRUCTURAL MARKERS OF RADIATION-INDUCED ADIPOSE TISSUE DAMAGE E. Guerra1, S. Lattanzio1, G. Furini2, G. Scabia2, E. Mota-Silva2, M. Maffei2, S. Cinti3, R. Di Pietro1 | 1Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2CNR Institute of Clinical Physiology, Pisa, Italy; 3Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche (Polytechnic University of Marche), Ancona, Italy
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P32 | BLOCKING CANCER CELL MOVEMENT: THE ROLE OF PAXILLIN AND EZRIN IN CERVICAL TUMOR M. Hałas-Wiśniewska1, W. Arendt1, M. Gagat1,2, M. Izdebska1 | 1Department of Histology and Embryology, Nicolaus Copernicus University in Toruń, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Poland; 2Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland
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P33 | IMPACT OF CYCLIN C EXPRESSION ON THE AGGRESSIVENESS OF A549 NON-SMALL CELL LUNG CANCER CELLS V. Havryliuk | Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland
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P34 | ADJUDIN-INDUCED MODEL IN RATS REVEALS HIPPO SIGNALING PATHWAY ACTIVITY IN THE TESTIS İ. İnanç1, O. Bender2, A. Atalay2, E. Erdemli1 | 1Ankara University, Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye; 2Ankara University, Biotechnology Institute, Ankara, Türkiye
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P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES İ. İnanç1, E. Baysal1, O. Bender2, A. Atalay2, E. Erdemli1 | 1Ankara University, Faculty of Medicine, Department of Histology and Embryology, Ankara, Türkiye; 2Ankara University, Biotechnology Institute, Ankara, Türkiye
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P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY T. Ishizuka, K. M. Aung, T. Kubota, B. Lkham-Erdene, K. Kai, Y. Hishikawa | Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
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P37 | THE ROLE OF ACTIN-BINDING PROTEINS IN ENDOMETRIOSIS W. Arendt1, M. Hałas-Wiśniewska1, M. Gagat2, M. Izdebska1 | 1Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; 2Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland
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P38 | THE ROLE OF SPEXIN IN COLORECTAL CANCER J. Kiezun1, J. Godlewski1, M. Kiezun2, M. Gudelska1, K. Kisielewska1, A. E. Kowalczyk1, B. E. Krazinski1 | 1Department of Anatomy and Histology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland; 2Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Poland
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P39 | NEW PERSPECTIVES FOR THE EXPLOITATION OF FEMALE REPRODUCTIVE POTENTIAL IN MAMMALS: GENERATION OF GRANULOSA-LIKE CELLS FROM HUMAN ADIPOSE MESENCHYMAL STEM CELLS Y. Lacapra1, D. Farini1, G. Salvatore1, M.A. Ucci1, F.G. Klinger2, M. De Felici1, A. Camaio1 | 1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy: 2Saint Camillus International University of Health Sciences, Rome, Italy
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P40 | VOLUME ELECTRON MICROSCOPY REVEALS SPECIFIC FEATURES OF MITOTIC CELLS IN THE PINEAL ORGAN OF THE DOMESTIC TURKEY B. Lewczuk, N. Szyryńska, M. Prusik | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
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P41 | INVOLVEMENT OF THE DOLPHIN’S MELON IN IMMUNE FUNCTION G.P. Lombardo1, A. Miller2, L. Spiccia1, V. Natale1, F. Pellicanò1, G. Squadrito1, E. R. Lauriano1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina; 2Department of Veterinary Sciences, University of Messina, Messina, Italy
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P42 | PANCREATIC CANCER STEM CELLS AND FUNCTIONAL CHARACTERIZATION OF MIR-216A-5P G. Fenu1, C.G. Lison2, F. Etzi3, A. Pisano3, C. Farace3, A. Sabalic3, D. Tutedde3, J.A. Marchal4, R. Madeddu5 | 1Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy; 2Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; 3Department of Biomedical Science, University of Sassari, Sassari, Italy; 4Instituto de Investigación Biosanitaria ibs. GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; 5Department of Biomedical Science, University of Sassari, Sassari, Italy
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P43 | NEW INSIGHTS IN THE ACTIVATION OF FERROPTOSIS PROCESS DURING LIVER FIBROSIS R. Mancinelli1, S. Leone1, A. Casini1, R. Vaccaro1, M. Tagliafierro1, F.M. Bassi1, E. Bocci1, S. Vitale1, A. Franchitto2, L. Pannarale1, P. Onori1, E. Gaudio1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; 2Division of Health Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Italy
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P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti1,2, F. Beretti2, M. Malenchini2, M. Y. Follo1, F. Mancarella3, F. Bonafè3, F. Gherardini4, T. Maraldi2 | 1Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; 4Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
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P45 | TARGETING PRELAMIN A PROCESSING TO SENSITIZE GLIOBLASTOMA CELLS TO OXIDATIVE STRESS M.V. Marvi1, C. Evangelisti1, I. Rusciano1, I. Neri1, L.I. Cocco1, L. Manzoli1, C. Capanni2, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy; 2CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza», Unit of Bologna, Bologna, Italy / IRCCS Rizzoli Orthopedi, Institute, Bologna, Italy
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