Original Papers
Vol. 49 No. 1 (2005)
https://doi.org/10.4081/931

Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study

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Published: 29 June 2009
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C Barbato
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MT Ciotti
We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocalbased immunofluorescence.We found that neurokinin A and neurokinin B are present in CGNs but absent in astrocytes. while substance P is abundant in astrocytes but absent in CGNs. It is postulated that the different localization of tachykinin neuropeptides in CGNs and astroglial cells has a physiological role in the modulation of excitatory transmission.

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1.
Barbato C, Ciotti M. Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study. Eur J Histochem [Internet]. 2009 Jun. 29 [cited 2026 Apr. 15];49(1):87-92. Available from: https://www.ejh.it/ejh/article/view/931