GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

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Mário S. de Souza Albuquerque
Antônio F. da Silva-filho
Marina Ferraz Cordeiro
Maria de Fátima Deodato de Souza
Michael W.L. Quirino
Luiza R. Amorim Lima
Maira G. da Rocha Pitta
Mario R. Martins
Moacyr J.B. de Melo Rêgo *
(*) Corresponding Author:
Moacyr J.B. de Melo Rêgo | moacyr.rego@gmail.com

Abstract

Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.


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