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• THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4317

  206

• EXPLORING THE CYTOTOXIC AND APOPTOTIC ACTIVITIES OF PRUNUS SPINOSA ECOTYPE EXTRACT TRIGNO ON 3D AND 2D MODELS OF HUMAN CANCER CELLS A. Di Netta¹, A. Di Pauli², R. Vona³, C. Cittadini³, S. Meschini¹, M. Condello¹ | ¹ National Center for Drug Research and Evaluation, National Institute of Health, Rome, Italy; ² Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, «Sapienza» University of Rome, Rome, Italy: ³ National Center for Gender-Specific Medicine, National Institute of Health, Rome, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4319

  254

• BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL V. Panella¹, F. De Cecco², S. Franceschelli¹, M. A. Maggi³, S. Bisti⁴, A. Bravo Nuevo⁵, D. D’Ardes¹, F. Cipollone¹, L. Speranza¹ | ¹Department of Medicine and Aging Sciences, University «G. D’Annunzio», Chieti; ²Italian Institute of Technology, Genoa, Italy; ³Hortus Novus, L’Aquila, Italy; ⁴National Institute of Biostructure and Biosystem, Rome, Italy; ⁵Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, USA

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4320

  246

• NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4318

  249