Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis

  • Manuel Scimeca University of Rome “Tor Vergata”, Department of Biomedicine and Prevention, Italy. http://orcid.org/0000-0003-0585-1309
  • Simone Bischetti OrchideaLab S.r.l., Italy.
  • Harpreet Kaur Lamsira University of Rome "Tor Vergata", Department of Experimental Medicine and Surgery, Italy.
  • Rita Bonfiglio University of Rome "Tor Vergata", Department of Experimental Medicine and Surgery, Italy. http://orcid.org/0000-0003-4172-2977
  • Elena Bonanno | elena.bonanno@uniroma2.it University of Rome "Tor Vergata", Department of Experimental Medicine and Surgery, Italy.

Abstract

The Energy Dispersive X-ray (EDX) microanalysis is a technique of elemental analysis associated to electron microscopy based on the generation of characteristic Xrays that reveals the presence of elements present in the specimens. The EDX microanalysis is used in different biomedical fields by many researchers and clinicians. Nevertheless, most of the scientific community is not fully aware of its possible applications. The spectrum of EDX microanalysis contains both semi-qualitative and semi-quantitative information. EDX technique is made useful in the study of drugs, such as in the study of drugs delivery in which the EDX is an important tool to detect nanoparticles (generally, used to improve the therapeutic performance of some chemotherapeutic agents). EDX is also used in the study of environmental pollution and in the characterization of mineral bioaccumulated in the tissues. In conclusion, the EDX can be considered as a useful tool in all works that require element determination, endogenous or exogenous, in the tissue, cell or any other sample.

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Author Biographies

Manuel Scimeca, University of Rome “Tor Vergata”, Department of Biomedicine and Prevention
Department of Biomedicine and Prevenction, University of Rome Tor Vergata, Rome
Simone Bischetti, OrchideaLab S.r.l.
OrchideaLab S.r.l.
Harpreet Kaur Lamsira, University of Rome "Tor Vergata", Department of Experimental Medicine and Surgery
Department of Experimental Medicine and Surgery, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy
Rita Bonfiglio, University of Rome "Tor Vergata", Department of Experimental Medicine and Surgery
Department of Experimental Medicine and Surgery, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy
Elena Bonanno, University of Rome "Tor Vergata", Department of Experimental Medicine and Surgery
Department of Experimental Medicine and Surgery, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy
Published
2018-03-15
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Section
Reviews
Keywords:
Energy Dispersive X-ray (EDX) microanalysis, transmission electron microscopy, scanning electron microscopy, asbestos, calcifications, nanoparticles.
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How to Cite
Scimeca, M., Bischetti, S., Lamsira, H. K., Bonfiglio, R., & Bonanno, E. (2018). Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis. European Journal of Histochemistry, 62(1). https://doi.org/10.4081/ejh.2018.2841