DNA damage in acute myeloid leukemia patients of Northern Mexico

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Martha I. Dávila-Rodríguez *
Elva I. Cortés-Gutiérrez
Roberto Hernández-Valdés
Karla Guzmán-Cortés
Rosa E. De León-Cantú
Ricardo M. Cerda-Flores
Enrique Báez-De la Fuente
(*) Corresponding Author:
Martha I. Dávila-Rodríguez | marthadavila@cibinmty.net

Abstract

The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.


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