DNA damage in acute myeloid leukemia patients of Northern Mexico

  • Martha I. Dávila-Rodríguez | marthadavila@cibinmty.net Instituto Mexicano del Seguro Social, Mexico.
  • Elva I. Cortés-Gutiérrez Instituto Mexicano del Seguro Social, Mexico.
  • Roberto Hernández-Valdés Instituto Mexicano del Seguro Social, Mexico.
  • Karla Guzmán-Cortés Instituto Mexicano del Seguro Social, Mexico.
  • Rosa E. De León-Cantú Instituto Mexicano del Seguro Social, Mexico.
  • Ricardo M. Cerda-Flores Universidad Autónoma De Nuevo León, Mexico.
  • Enrique Báez-De la Fuente Instituto Mexicano del Seguro Social, Mexico.

Abstract

The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

Downloads

Download data is not yet available.
Published
2017-12-11
Section
Brief Reports
Supporting Agencies
Instituto Mexicano del Seguro Social, CONACYT.
Keywords:
DNA damage, acute myeloid leukemia, DNA breakage detection-fluorescence in situ hybridization, Mexico.
Statistics
Abstract views: 419

PDF: 100
HTML: 126
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Dávila-Rodríguez, M. I., Cortés-Gutiérrez, E. I., Hernández-Valdés, R., Guzmán-Cortés, K., De León-Cantú, R. E., Cerda-Flores, R. M., & Báez-De la Fuente, E. (2017). DNA damage in acute myeloid leukemia patients of Northern Mexico. European Journal of Histochemistry, 61(4). https://doi.org/10.4081/ejh.2017.2851