DNA damage in acute myeloid leukemia patients of Northern Mexico

  • Martha I. Dávila-Rodríguez | marthadavila@cibinmty.net Instituto Mexicano del Seguro Social, Mexico.
  • Elva I. Cortés-Gutiérrez Instituto Mexicano del Seguro Social, Mexico.
  • Roberto Hernández-Valdés Instituto Mexicano del Seguro Social, Mexico.
  • Karla Guzmán-Cortés Instituto Mexicano del Seguro Social, Mexico.
  • Rosa E. De León-Cantú Instituto Mexicano del Seguro Social, Mexico.
  • Ricardo M. Cerda-Flores Universidad Autónoma De Nuevo León, Mexico.
  • Enrique Báez-De la Fuente Instituto Mexicano del Seguro Social, Mexico.

Abstract

The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

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Published
2017-12-11
Info
Issue
Section
Brief Reports
Supporting Agencies
Instituto Mexicano del Seguro Social, CONACYT.
Keywords:
DNA damage, acute myeloid leukemia, DNA breakage detection-fluorescence in situ hybridization, Mexico.
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How to Cite
Dávila-Rodríguez, M. I., Cortés-Gutiérrez, E. I., Hernández-Valdés, R., Guzmán-Cortés, K., De León-Cantú, R. E., Cerda-Flores, R. M., & Báez-De la Fuente, E. (2017). DNA damage in acute myeloid leukemia patients of Northern Mexico. European Journal of Histochemistry, 61(4). https://doi.org/10.4081/ejh.2017.2851