Localization and expression of two human b-defensins (HBD-1 and HBD-2) in intestinal biopsies of celiac patients

Abstract

Innate immunity is the first line of defense against microorganisms in vertebrates and acts by providing an initial barrier to microorganisms and triggering adaptive immune responses (Ganz and Lehrer 1999; Oppenheim et al., 2002). Peptides such as b-defensins are an important component of this defense, both providing a broad spectrum of antimicrobial activity against bacteria, fungi, mycobacteria and several enveloped viruses (Ganz and Leher, 1994) and showing chemotactic activity by linking and activating CCR6 (Hoover DM et al. , 2002). b-defensins are small cationic peptides that vary in their expression patterns and spectrum of pathogen specificity (Ganz and Leher, 2002).

Downloads

Download data is not yet available.
Published
2009-06-26
Section
Letters to the Editor
Statistics
Abstract views: 164

PDF: 163
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Boniotto, M., Pirulli, D., Verga Falzacappa, M., Trevisiol, C., Gerarduzzi, T., & Crovella, S. (2009). Localization and expression of two human b-defensins (HBD-1 and HBD-2) in intestinal biopsies of celiac patients. European Journal of Histochemistry, 47(4), 389-392. https://doi.org/10.4081/852